ID Card:
| Full name: |
Fibrillarin-like rRNA/tRNA 2′-O-methyltransferase |
| Synonym: |
aFib, Fibrillarin-like |
| UniProt: |
D4GZN3 |
| Complex: |
C/D RNP |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - Cm
t:None - Um
|
| Level of experimental evidence: |
5 |
| Level of experimental reliability: |
5 |
Protein sequence:
MSDDGSAADAALPDGVERRTFGGRERLSTRGEPVYGEPVDSDGWRAWDAGRSKLGAMLELGMDTGLVGGESVLYLGAASGTTVSHVADFAGPTYAVEFAPRPVRDLVGVAEDRDNLFPLLKDARDPDSYAHVVEAGIDCLVMDVATRGQATVAVRNRQFLADDGRLLMAVKARSEDVTAEPDDVFDDVIAELDSAYELLETARLDRFHADHLGIVARPK
Comments:
Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
C:Cm
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
34 |
|
|
|
|
|
|
|
|
U:Um
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
39 |
|
|
|
|
|
|
|
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| RNomics and Modomics in the halophilic archaea Haloferax volcanii: identification of RNA modification genes. |
Grosjean H; Gaspin C; Marck C; Decatur WA; de Crécy-Lagard V |
BMC Genomics |
[details]
|
18844986
|
10.1186/1471-2164-9-470
|