Hausmann S |
Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2). |
J Biol Chem |
16046409 |
Urbonavicius J |
Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria--evolutionary implications. |
Nucleic Acids Res |
16027442 |
Marmier-Gourrier N |
A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA. |
RNA |
12810916 |
Hager J |
Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. |
J Bacteriol |
15375145 |
Sunita S |
Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. |
Nucleic Acids Res |
17576679 |
Kolodrubetz D |
Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. |
Yeast |
2063628 |
Motorin Y |
Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. |
RNA |
10445884 |
Walbott H |
Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. |
RNA |
17475914 |
Motorin Y |
The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity. |
RNA |
9671058 |
Behm-Ansmant I |
The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs. |
RNA |
14561887 |
Grosjean H |
Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? |
Trends Biochem Sci |
15450604 |
Behm-Ansmant I |
The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. |
RNA |
17684231 |
Kotelawala L |
Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. |
RNA |
18025252 |
Ikeuchi Y |
The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. |
EMBO J |
18668122 |
Kambampati R |
IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. |
Biochemistry |
10600118 |
Bujnicki JM |
Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family. |
J Mol Microbiol Biotechnol |
12125821 |
Purushothaman SK |
Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. |
Mol Cell Biol |
15899842 |
Hamilton CS |
Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine. |
Biochemistry |
17002302 |
Bujnicki JM |
Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. |
J Mol Evol |
12355263 |
de Beus E |
Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. |
J Cell Biol |
7806561 |
Wolfe MD |
Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. |
J Biol Chem |
14594807 |
Jiang W |
An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. |
Mol Cell Biol |
8336724 |
Salazar JC |
A truncated aminoacyl-tRNA synthetase modifies RNA. |
Proc Natl Acad Sci U S A |
15096612 |
Pierrel F |
MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA. |
J Biol Chem |
15339930 |
Roovers M |
A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. |
Nucleic Acids Res |
14739239 |
Hallberg BM |
The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. |
J Mol Biol |
16793063 |
Pintard L |
MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. |
EMBO J |
11867542 |
Caldas T |
The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. |
J Biol Chem |
10748051 |
Hausmann S |
Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). |
J Biol Chem |
15590684 |
Frey B |
New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. |
J Bacteriol |
3129401 |
Wrzesinski J |
Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli. |
Biochemistry |
7612632 |
Mouaikel J |
Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. |
Mol Cell |
11983179 |
Romanowski MJ |
Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold. |
Proteins |
12001236 |
Cabedo H |
The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. |
EMBO J |
10601028 |
Clery A |
Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. |
Mol Cell Biol |
17145781 |
Jacq C |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Nature |
9169867 |
Kato T |
A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. |
Cancer Res |
15994936 |
Watanabe M |
Biosynthesis of archaeosine, a novel derivative of 7-deazaguanosine specific to archaeal tRNA, proceeds via a pathway involving base replacement on the tRNA polynucleotide chain. |
J Biol Chem |
9242689 |
Lapeyre B |
Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. |
Mol Cell |
15546625 |
Pintard L |
Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. |
EMBO J |
11927565 |
Agarwalla S |
Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. |
J Biol Chem |
11779873 |
Massenet S |
Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. |
Mol Cell Biol |
10022901 |
Hagervall TG |
Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. |
Mol Gen Genet |
6387395 |
Lesnyak DV |
Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. |
J Biol Chem |
17189261 |
Kalhor HR |
Novel methyltransferase for modified uridine residues at the wobble position of tRNA. |
Mol Cell Biol |
14645538 |
Grimm C |
Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase. |
Biochem Biophys Res Commun |
17083917 |
Noma A |
Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. |
EMBO J |
16642040 |
Bonnerot C |
Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. |
Mol Cell |
14636587 |
Decoster E |
MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. |
J Mol Biol |
8392589 |
Gu XR |
Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. |
Biochemistry |
10194318 |
Del Campo M |
Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. |
RNA |
11720289 |
Slany RK |
A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. |
Biochemistry |
8347586 |
Soma A |
An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. |
Mol Cell |
14527414 |
De Bie LG |
The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase. |
J Bacteriol |
12730187 |
Brisson-Noel A |
Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. |
J Bacteriol |
2832378 |
Michel G |
The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. |
Structure |
12377117 |
Watanabe K |
Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes. |
J Biol Chem |
16963456 |
Gutgsell N |
Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. |
RNA |
11142385 |
Jager G |
The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. |
J Bacteriol |
14729701 |
Bujnicki JM |
Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. |
Nucleic Acids Res |
15121902 |
Hagervall TG |
Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities. |
J Biol Chem |
3298234 |
Stengl B |
Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism. |
Chembiochem |
16206323 |
Bussey H |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Nature |
9169875 |
Calvo O |
GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. |
Mol Cell Biol |
10330157 |
Tsukamoto T |
Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. |
Biochem Biophys Res Commun |
9345280 |
Lauhon CT |
Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. |
J Biol Chem |
14978044 |
Gutgsell NS |
A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain. |
RNA |
11453071 |
Kressler D |
Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. |
Nucleic Acids Res |
10556316 |
Toh SM |
The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. |
RNA |
18025251 |
Lesnyak DV |
Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. |
J Mol Biol |
17010378 |
Yim L |
The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function. |
J Biol Chem |
12730230 |
Wolf J |
tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. |
EMBO J |
12110595 |
Wu P |
Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. |
J Biol Chem |
9632712 |
Watanabe K |
Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. |
J Biol Chem |
15637073 |
Caillet J |
Molecular cloning of the Escherichia coli miaA gene involved in the formation of delta 2-isopentenyl adenosine in tRNA. |
J Bacteriol |
3045085 |
Waas WF |
Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. |
J Biol Chem |
16162496 |
Gutgsell NS |
The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli. |
RNA |
15928344 |
Lauhon CT |
Requirement for IscS in biosynthesis of all thionucleosides in Escherichia coli. |
J Bacteriol |
12446632 |
Hopper AK |
tRNA transfers to the limelight. |
Genes Dev |
12533506 |
Baker DL |
RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP. |
Genes Dev |
15870259 |
Gustafsson C |
Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant. |
J Bacteriol |
9440525 |
Leinfelder W |
In vitro synthesis of selenocysteinyl-tRNA(UCA) from seryl-tRNA(UCA): involvement and characterization of the selD gene product. |
Proc Natl Acad Sci U S A |
2405383 |
Basturea GN |
Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family. |
RNA |
16431987 |
Mathews I |
Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. |
Proteins |
15822125 |
Ny T |
Cloning and restriction mapping of the trmA gene coding for transfer ribonucleic acid (5-methyluridine)-methyltransferase in Escherichia coli K-12. |
J Bacteriol |
6247318 |
Nordlund ME |
Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae. |
RNA |
10864043 |
Appel CD |
Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2'-O-methylation. |
RNA |
17438123 |
Xing F |
The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. |
J Biol Chem |
14970222 |
Rozenski J |
The RNA Modification Database: 1999 update. |
Nucleic Acids Res |
9847178 |
Swairjo MA |
Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
16511203 |
Campanacci V |
The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. |
J Mol Biol |
15003446 |
Bishop AC |
Identification of the tRNA-dihydrouridine synthase family. |
J Biol Chem |
11983710 |
Gerber AP |
An adenosine deaminase that generates inosine at the wobble position of tRNAs. |
Science |
10550050 |
Nakanishi K |
Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. |
Proc Natl Acad Sci U S A |
15894617 |
Tettelin H |
The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. |
Nature |
9169869 |
Hamma T |
The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. |
Nat Struct Mol Biol |
16286935 |
Blaise M |
Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. |
Biochimie |
16164993 |
Yim L |
Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. |
Nucleic Acids Res |
17062623 |
Lee TT |
A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. |
Cell |
15766524 |
Cupp-Vickery JR |
Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. |
J Mol Biol |
15050828 |
Nasvall SJ |
The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. |
RNA |
15383682 |
Philippsen P |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. |
Nature |
9169873 |
Esberg B |
Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli. |
J Bacteriol |
10572129 |
Ollagnier-de-Choudens S |
Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. |
J Biol Chem |
11319236 |
Bujnicki JM |
Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. |
J Mol Microbiol Biotechnol |
11763974 |
Henras A |
Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. |
EMBO J |
9843512 |
Girard JP |
GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast. |
EMBO J |
1531632 |
Purta E |
Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis. |
Proteins |
15789416 |
Alexandrov A |
Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. |
RNA |
12403464 |
Zhang X |
The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation. |
RNA |
16601205 |
Hellmuth K |
Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p. |
Nucleic Acids Res |
11095668 |
Ozanick S |
The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. |
RNA |
16043508 |
Ansmant I |
Identification of the Saccharomyces cerevisiae RNA:pseudouridine synthase responsible for formation of psi(2819) in 21S mitochondrial ribosomal RNA. |
Nucleic Acids Res |
10756195 |
Bujnicki JM |
In silico analysis of the tRNA:m1A58 methyltransferase family: homology-based fold prediction and identification of new members from Eubacteria and Archaea. |
FEBS Lett |
11684083 |
Anderson J |
The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. |
Genes Dev |
9851972 |
Wilkinson ML |
The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. |
RNA |
17242307 |
Bujnicki JM |
Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. |
FASEB J |
11053259 |
Bystrom AS |
The structural gene (trmD) for the tRNA(m1G)methyltransferase is part of a four polypeptide operon in Escherichia coli K-12. |
Mol Gen Genet |
6298574 |
Dong X |
Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8. |
RNA Biol |
17114947 |
Suzuki Y |
Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. |
J Mol Biol |
17727881 |
Motorin Y |
Transfer RNA recognition by the Escherichia coli delta2-isopentenyl-pyrophosphate:tRNA delta2-isopentenyl transferase: dependence on the anticodon arm structure. |
RNA |
9214656 |
Astrom SU |
Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. |
Cell |
7954819 |
Bjork GR |
Genetic dissection of synthesis and function of modified nucleosides in bacterial transfer RNA. |
Prog Nucleic Acid Res Mol Biol |
7538683 |
Pan H |
The crystal structure of E. coli rRNA pseudouridine synthase RluE. |
J Mol Biol |
17320904 |
Dubois DY |
An aminoacyl-tRNA synthetase-like protein encoded by the Escherichia coli yadB gene glutamylates specifically tRNAAsp. |
Proc Natl Acad Sci U S A |
15096594 |
Soderberg T |
Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop. |
Biochemistry |
10828971 |
Lafontaine D |
The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. |
Genes Dev |
7590228 |
Hur S |
How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. |
Mol Cell |
17466622 |
Schubot FD |
Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. |
Protein Sci |
11567089 |
Anderson J |
The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. |
Proc Natl Acad Sci U S A |
10779558 |
Dihanich ME |
Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. |
Mol Cell Biol |
3031456 |
Kaya Y |
A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya. |
RNA |
12756329 |
Kalhor HR |
Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. |
Arch Biochem Biophys |
11697862 |
Roovers M |
Formation of the conserved pseudouridine at position 55 in archaeal tRNA. |
Nucleic Acids Res |
16920741 |
Bujnicki JM |
Sequence analysis and structure prediction of aminoglycoside-resistance 16S rRNA:m7G methyltransferases. |
Acta Microbiol Pol |
11518396 |
Vaidyanathan PP |
RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA. |
RNA |
17872507 |
Kolman C |
SPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing. |
J Bacteriol |
8444805 |
Johansson MJ |
The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. |
RNA |
15037780 |
Bugl H |
RNA methylation under heat shock control. |
Mol Cell |
10983982 |
McCleverty CJ |
Crystal structure of human Pus10, a novel pseudouridine synthase. |
J Mol Biol |
17900615 |
Basturea GN |
Substrate specificity and properties of the Escherichia coli 16S rRNA methyltransferase, RsmE. |
RNA |
17872509 |
Taylor AB |
The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. |
Nucleic Acids Res |
18208838 |
Persson BC |
The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. |
Nucleic Acids Res |
9321663 |
Leipuviene R |
Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. |
J Bacteriol |
14729702 |
Wachino J |
Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. |
Antimicrob Agents Chemother |
17875999 |
Pintard L |
Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro. |
Mol Cell Biol |
10648622 |
Behm-Ansmant I |
Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. |
J Biol Chem |
15466869 |
Kambampati R |
MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. |
Biochemistry |
12549933 |
Andersen NM |
YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407. |
J Mol Biol |
16678201 |
Purta E |
YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. |
RNA |
18755835 |
Matte A |
Structure of the pseudouridine synthase RsuA from Haemophilus influenzae. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
16511038 |
Okamoto S |
Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. |
Mol Microbiol |
17238915 |
Teplova M |
The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. |
Protein Sci |
11206077 |
Caldas T |
Translational defects of Escherichia coli mutants deficient in the Um(2552) 23S ribosomal RNA methyltransferase RrmJ/FTSJ. |
Biochem Biophys Res Commun |
10814528 |
Conrad J |
The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA. |
J Biol Chem |
9660827 |
Carnahan RH |
Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex. |
Eukaryot Cell |
15755920 |
Cupp-Vickery JR |
Crystal structure of IscS, a cysteine desulfurase from Escherichia coli. |
J Mol Biol |
12860127 |
Xing F |
A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. |
RNA |
12003496 |
Kalhor HR |
A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. |
Biochem Biophys Res Commun |
16005430 |
Cavaille J |
The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. |
RNA |
9917067 |
Elkins PA |
Insights into catalysis by a knotted TrmD tRNA methyltransferase. |
J Mol Biol |
14583191 |
Purta E |
The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase. |
BMC Mol Biol |
16848900 |
Na JG |
Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae. |
Genetics |
1325384 |
Sergiev PV |
The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. |
J Mol Biol |
18021804 |
Bjork GR |
A primordial tRNA modification required for the evolution of life? |
EMBO J |
11226173 |
Colby G |
MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. |
J Biol Chem |
9774408 |
Matsumoto K |
RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex). |
FEBS Lett |
17382321 |
Tomoyasu T |
The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression. |
J Bacteriol |
8444796 |
Reuter K |
Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. |
J Bacteriol |
1706703 |
Madsen CT |
Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry. |
Nucleic Acids Res |
12907714 |
Pan H |
Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. |
Proc Natl Acad Sci U S A |
14566049 |
Hong B |
Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. |
Mol Cell Biol |
8972218 |
Reynaud A |
Disruption and functional analysis of six ORFs of chromosome IV: YDL103c (QRI1), YDL105w (QRI2), YDL112w (TRM3), YDL113c, YDL116w (NUP84) and YDL167c (NRP1). |
Yeast |
11180460 |
Tkaczuk KL |
Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. |
BMC Bioinformatics |
17338813 |
Clancy MJ |
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. |
Nucleic Acids Res |
12384598 |
Mueller EG |
Identification of a gene involved in the generation of 4-thiouridine in tRNA. |
Nucleic Acids Res |
9592144 |
Jablonowski D |
tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. |
Mol Microbiol |
16390459 |
Lecointe F |
Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. |
J Biol Chem |
9430663 |
Hager J |
Active site in RrmJ, a heat shock-induced methyltransferase. |
J Biol Chem |
12181314 |
Mathevon C |
tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase. |
Proc Natl Acad Sci U S A |
17679698 |
Sirum-Connolly K |
Functional requirement of a site-specific ribose methylation in ribosomal RNA. |
Science |
8266080 |
Hong B |
Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. |
Nucleic Acids Res |
11452018 |
Sergiev PV |
Ribosomal RNA guanine-(N2)-methyltransferases and their targets. |
Nucleic Acids Res |
17389639 |
Mao X |
Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. |
Mol Cell Biol |
7623811 |
Bujnicki JM |
mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. |
BMC Bioinformatics |
11472630 |
Hagervall TG |
Reduced misreading of asparagine codons by Escherichia coli tRNALys with hypomodified derivatives of 5-methylaminomethyl-2-thiouridine in the wobble position. |
J Mol Biol |
9811540 |
Monleon D |
Structural insights into the GTPase domain of Escherichia coli MnmE protein. |
Proteins |
17143896 |
Nilsson K |
The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium. |
J Bacteriol |
12446633 |
Hoang C |
Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. |
RNA |
15208439 |
Bujnicki JM |
Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. |
RNA |
15247431 |
White J |
Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. |
Mol Cell Biol |
18332120 |
Wrzesinski J |
A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). |
RNA |
7493321 |
Lee TT |
Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. |
Structure |
15016356 |
Henriquez R |
Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. |
J Biol Chem |
2298745 |
O'Farrell HC |
Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. |
RNA |
16540698 |
Waterman DG |
Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. |
J Mol Biol |
16343540 |
Ansmant I |
Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae. |
J Biol Chem |
11406626 |
Liiv A |
Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. |
BMC Mol Biol |
16053518 |
Martinez-Vicente M |
Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification. |
J Biol Chem |
15983041 |
Guan MX |
Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. |
Am J Hum Genet |
16826519 |
Rashid R |
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. |
Mol Cell |
16427014 |
Sergiev PV |
Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA. |
J Mol Biol |
17010380 |
Corollo D |
Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. |
Acta Crystallogr D Biol Crystallogr |
10089432 |
Roovers M |
The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK). |
Nucleic Acids Res |
18420655 |
Tkaczuk KL |
Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. |
BMC Evol Biol |
16433904 |
Lafontaine DL |
The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. |
Genes Dev |
9472021 |
Lovgren JM |
The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. |
J Bacteriol |
11698387 |
Nishimura K |
Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants. |
J Bacteriol |
17573471 |
Kaya Y |
Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold. |
J Biol Chem |
14999002 |
Scrima A |
The structure of the TrmE GTP-binding protein and its implications for tRNA modification. |
EMBO J |
15616586 |
Jackman JE |
Identification of the yeast gene encoding the tRNA m1G methyltransferase responsible for modification at position 9. |
RNA |
12702816 |
Gerber A |
Tad1p, a yeast tRNA-specific adenosine deaminase, is related to the mammalian pre-mRNA editing enzymes ADAR1 and ADAR2. |
EMBO J |
9707437 |
Walbott H |
The carboxyl-terminal extension of yeast tRNA m5C methyltransferase enhances the catalytic efficiency of the amino-terminal domain. |
J Biol Chem |
17567576 |
Bujnicki JM |
RNA:(guanine-N2) methyltransferases RsmC/RsmD and their homologs revisited--bioinformatic analysis and prediction of the active site based on the uncharacterized Mj0882 protein structure. |
BMC Bioinformatics |
11929612 |
Ellis SR |
Isolation and characterization of the TRM1 locus, a gene essential for the N2,N2-dimethylguanosine modification of both mitochondrial and cytoplasmic tRNA in Saccharomyces cerevisiae. |
J Biol Chem |
2426253 |
Dabbs ER |
The ribosomal components responsible for kasugamycin dependence, and its suppression, in a mutant of Escherichia coli. |
Mol Gen Genet |
6988670 |
Das K |
Crystal structure of RlmAI: implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site. |
Proc Natl Acad Sci U S A |
14999102 |
Gautier T |
Nucleolar KKE/D repeat proteins Nop56p and Nop58p interact with Nop1p and are required for ribosome biogenesis. |
Mol Cell Biol |
9372940 |
Mouaikel J |
Sequence-structure-function relationships of Tgs1, the yeast snRNA/snoRNA cap hypermethylase. |
Nucleic Acids Res |
12907733 |
Gagnon KT |
Assembly of the archaeal box C/D sRNP can occur via alternative pathways and requires temperature-facilitated sRNA remodeling. |
J Mol Biol |
16949610 |
Kaminska KH |
Structural bioinformatics analysis of enzymes involved in the biosynthesis pathway of the hypermodified nucleoside ms(2)io(6)A37 in tRNA. |
Proteins |
17910062 |
Constantinesco F |
Transfer RNA modification enzymes from Pyrococcus furiosus: detection of the enzymatic activities in vitro. |
Nucleic Acids Res |
9973619 |
Tscherne JS |
Purification, cloning, and characterization of the 16S RNA m5C967 methyltransferase from Escherichia coli. |
Biochemistry |
10026269 |
Shibagaki Y |
mRNA capping enzyme. Isolation and characterization of the gene encoding mRNA guanylytransferase subunit from Saccharomyces cerevisiae. |
J Biol Chem |
1315757 |
Watts JM |
Ligand-mediated anticodon conformational changes occur during tRNA methylation by a TrmD methyltransferase. |
Biochemistry |
15850396 |
Hoang C |
Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure. |
Mol Cell |
17188032 |
Seidel-Rogol BL |
Human mitochondrial transcription factor B1 methylates ribosomal RNA at a conserved stem-loop. |
Nat Genet |
12496758 |
Persson BC |
Isolation of the gene (miaE) encoding the hydroxylase involved in the synthesis of 2-methylthio-cis-ribozeatin in tRNA of Salmonella typhimurium and characterization of mutants. |
J Bacteriol |
8253666 |
Casamayor A |
Sequence analysis of a 13.4 kbp fragment from the left arm of chromosome XV reveals a malate dehydrogenase gene, a putative Ser/Thr protein kinase, the ribosomal L25 gene and four new open reading frames. |
Yeast |
8896265 |
Scrima A |
Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. |
EMBO J |
16763562 |
Yan Q |
Human TRMU encoding the mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase is a putative nuclear modifier gene for the phenotypic expression of the deafness-associated 12S rRNA mutations. |
Biochem Biophys Res Commun |
16513084 |
Nolivos S |
The K-loop, a general feature of the Pyrococcus C/D guide RNAs, is an RNA structural motif related to the K-turn. |
Nucleic Acids Res |
16293637 |
Raychaudhuri S |
Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA. |
J Biol Chem |
10383384 |
Aravind L |
THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases. |
Trends Biochem Sci |
11295541 |
Alexandrov A |
tRNA m7G methyltransferase Trm8p/Trm82p: evidence linking activity to a growth phenotype and implicating Trm82p in maintaining levels of active Trm8p. |
RNA |
15811913 |
Kammen HO |
Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I. |
J Biol Chem |
3276686 |
Blaise M |
A minimalist glutamyl-tRNA synthetase dedicated to aminoacylation of the tRNAAsp QUC anticodon. |
Nucleic Acids Res |
15150343 |
Xie W |
Structure of tRNA dimethylallyltransferase: RNA modification through a channel. |
J Mol Biol |
17292915 |
Sunita S |
Domain organization and crystal structure of the catalytic domain of E.coli RluF, a pseudouridine synthase that acts on 23S rRNA. |
J Mol Biol |
16712869 |
Van Lanen SG |
From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. |
Proc Natl Acad Sci U S A |
15767583 |
Slany RK |
Transfer and isomerization of the ribose moiety of AdoMet during the biosynthesis of queuosine tRNAs, a new unique reaction catalyzed by the QueA protein from Escherichia coli. |
Biochimie |
7849103 |
Torchet C |
The complete set of H/ACA snoRNAs that guide rRNA pseudouridylations in Saccharomyces cerevisiae. |
RNA |
15923376 |
Stengl B |
Crystal structures of tRNA-guanine transglycosylase (TGT) in complex with novel and potent inhibitors unravel pronounced induced-fit adaptations and suggest dimer formation upon substrate binding. |
J Mol Biol |
17524419 |
Lecointe F |
Lack of pseudouridine 38/39 in the anticodon arm of yeast cytoplasmic tRNA decreases in vivo recoding efficiency. |
J Biol Chem |
12058040 |
Nishimura K |
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). |
J Bacteriol |
17384192 |
Tscherne JS |
Purification, cloning, and characterization of the 16 S RNA m2G1207 methyltransferase from Escherichia coli. |
J Biol Chem |
9873033 |
Becker HF |
The yeast gene YNL292w encodes a pseudouridine synthase (Pus4) catalyzing the formation of psi55 in both mitochondrial and cytoplasmic tRNAs. |
Nucleic Acids Res |
9358157 |
Conrad J |
16S ribosomal RNA pseudouridine synthase RsuA of Escherichia coli: deletion, mutation of the conserved Asp102 residue, and sequence comparison among all other pseudouridine synthases. |
RNA |
10376875 |
Rodriguez V |
Chromosome 8 BAC array comparative genomic hybridization and expression analysis identify amplification and overexpression of TRMT12 in breast cancer. |
Genes Chromosomes Cancer |
17440925 |
Singh SK |
Sequential 2'-O-methylation of archaeal pre-tRNATrp nucleotides is guided by the intron-encoded but trans-acting box C/D ribonucleoprotein of pre-tRNA. |
J Biol Chem |
15347671 |
Veres Z |
A purified selenophosphate-dependent enzyme from Salmonella typhimurium catalyzes the replacement of sulfur in 2-thiouridine residues in tRNAs with selenium. |
Proc Natl Acad Sci U S A |
7520175 |
Dobbyn HC |
Analysis of Snu13p mutations reveals differential interactions with the U4 snRNA and U3 snoRNA. |
RNA |
14730029 |
Hansen MA |
Posttranscriptional modifications in the A-loop of 23S rRNAs from selected archaea and eubacteria. |
RNA |
11911366 |
Kirpekar F |
The archaeon Haloarcula marismortui has few modifications in the central parts of its 23S ribosomal RNA. |
J Mol Biol |
15826654 |
Kaminska KH |
Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria. |
Nucleic Acids Res |
20007606 |
Boal AK |
Structural basis for methyl transfer by a radical SAM enzyme. |
Science |
21527678 |
Kehrenberg C |
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. |
Mol Microbiol |
16091044 |
Giessing AM |
Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria. |
RNA |
19144912 |
Yan F |
RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA |
J Am Chem Soc |
20184321 |
Yan F |
RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift. |
Proc Natl Acad Sci U S A |
21368151 |
Purta E |
YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA. |
Mol Microbiol |
19400805 |
Purta E |
YccW is the m5C methyltransferase specific for 23S rRNA nucleotide 1962. |
J Mol Biol |
18786544 |
Sunita S |
Crystal structure of the Escherichia coli 23S rRNA:m5C methyltransferase RlmI (YccW) reveals evolutionary links between RNA modification enzymes. |
J Mol Biol |
18789337 |
Roovers M |
Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA. |
Proteins |
18186482 |
Pearson D |
Assay of both activities of the bifunctional tRNA-modifying enzyme MnmC reveals a kinetic basis for selective full modification of cmnm5s2U to mnm5s2U. |
Nucleic Acids Res |
21306992 |
Kitamura A |
Crystal structure of the bifunctional tRNA modification enzyme MnmC from Escherichia coli. |
Protein Sci |
21574198 |
Meyer S |
Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate. |
J Mol Biol |
18565343 |
Franke J |
Hypermethylation of yeast telomerase RNA by the snRNA and snoRNA methyltransferase Tgs1. |
J Cell Sci |
18840651 |
Numata T |
Snapshots of tRNA sulphuration via an adenylated intermediate. |
Nature |
16871210 |
Foster PG |
The first structure of an RNA m5C methyltransferase, Fmu, provides insight into catalytic mechanism and specific binding of RNA substrate. |
Structure |
14656444 |
Alian A |
Structure of a TrmA-RNA complex: A consensus RNA fold contributes to substrate selectivity and catalysis in m5U methyltransferases. |
Proc Natl Acad Sci U S A |
18451029 |
Leulliot N |
Structure of the yeast tRNA m7G methylation complex. |
Structure |
18184583 |
Nakanishi K |
Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase. |
Nature |
19847269 |
Pulicherla N |
Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases. |
J Mol Biol |
19520088 |
Lima CD |
Structure and mechanism of yeast RNA triphosphatase: an essential component of the mRNA capping apparatus. |
Cell |
10589681 |
Ericsson UB |
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold. |
FEBS Lett |
15135053 |
Kim J |
Structural and kinetic characterization of Escherichia coli TadA, the wobble-specific tRNA deaminase. |
Biochemistry |
16700551 |
Wright JR |
Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA, and RluA reveals uniformly slow catalysis. |
RNA |
21998096 |
Christian T |
Control of catalytic cycle by a pair of analogous tRNA modification enzymes. |
J Mol Biol |
20452364 |
Gurha P |
Archaeal Pus10 proteins can produce both pseudouridine 54 and 55 in tRNA. |
RNA |
18952823 |
Behm-Ansmant I |
A previously unidentified activity of yeast and mouse RNA:pseudouridine synthases 1 (Pus1p) on tRNAs. |
RNA |
16804160 |
Arluison V |
RNA:pseudouridine synthetase Pus1 from Saccharomyces cerevisiae: oligomerization property and stoichiometry of the complex with yeast tRNA(Phe). |
Biochimie |
10492022 |
Arluison V |
Pseudouridine synthetase Pus1 of Saccharomyces cerevisiae: kinetic characterisation, tRNA structural requirement and real-time analysis of its complex with tRNA. |
J Mol Biol |
10356324 |
Arluison V |
Transfer RNA-pseudouridine synthetase Pus1 of Saccharomyces cerevisiae contains one atom of zinc essential for its native conformation and tRNA recognition. |
Biochemistry |
9585540 |
Brégeon D |
Translational misreading: a tRNA modification counteracts a +2 ribosomal frameshift. |
Genes Dev |
11544186 |
Moukadiri I |
Evolutionarily conserved proteins MnmE and GidA catalyze the formation of two methyluridine derivatives at tRNA wobble positions. |
Nucleic Acids Res |
19767610 |
Umeda N |
Mitochondria-specific RNA-modifying enzymes responsible for the biosynthesis of the wobble base in mitochondrial tRNAs. Implications for the molecular pathogenesis of human mitochondrial diseases. |
J Biol Chem |
15509579 |
Gu W |
tRNAHis maturation: an essential yeast protein catalyzes addition of a guanine nucleotide to the 5' end of tRNAHis. |
Genes Dev |
14633974 |
Hyde SJ |
tRNAHis guanylyltransferase (THG1), a unique 3′-5′ nucleotidyl transferase, shares unexpected structural homology with canonical 5′-3′ DNA polymerases. |
Proc Natl Acad Sci U S A |
21059936 |
Basturea GN |
YhiQ Is RsmJ, the Methyltransferase Responsible for Methylation of G1516 in 16S rRNA of E. coli. |
J Mol Biol |
22079366 |
Kimura S |
Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA. |
Nucleic Acids Res |
19965768 |
Havelund JF |
Identification of 5-hydroxycytidine at position 2501 concludes characterization of modified nucleotides in E. coli 23S rRNA. |
J Mol Biol |
21723290 |
Beauclerk AA |
Sites of action of two ribosomal RNA methylases responsible for resistance to aminoglycosides. |
J Mol Biol |
2441068 |
Macmaster R |
Structural insights into the function of aminoglycoside-resistance A1408 16S rRNA methyltransferases from antibiotic-producing and human pathogenic bacteria. |
Nucleic Acids Res |
20639535 |
Husain N |
Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit. |
Nucleic Acids Res |
21062819 |
Miles ZD |
Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification. |
Proc Natl Acad Sci U S A |
21502530 |
Hausmann S |
Biochemical and genetic analysis of RNA cap guanine-N2 methyltransferases from Giardia lamblia and Schizosaccharomyces pombe. |
Nucleic Acids Res |
17284461 |
Chen C |
Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. |
PLoS One |
21687733 |
Mazauric MH |
Trm112p is a 15-kDa zinc finger protein essential for the activity of two tRNA and one protein methyltransferases in yeast. |
J Biol Chem |
20400505 |
Golovina AY |
The yfiC gene of E. coli encodes an adenine-N6 methyltransferase that specifically modifies A37 of tRNA1Val(cmo5UAC). |
RNA |
19383770 |
Zebarjadian Y |
Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA. |
Mol Cell Biol |
10523634 |
Krog JS |
3-(3-amino-3-carboxypropyl)-5,6-Dihydrouridine is one of two novel post-transcriptional modifications in tRNA(Lys) (UUU) from Trypanosoma brucei. |
FEBS J |
22040320 |
Meyer B |
The Bowen-Conradi syndrome protein Nep1 (Emg1) has a dual role in eukaryotic ribosome biogenesis, as an essential assembly factor and in the methylation of Psi1191 in yeast 18S rRNA. |
Nucleic Acids Res |
20972225 |
Kasai H |
Structure of wye (Yt base) and wyosine (Yt) from Torulopsis utilis phenylalanine transfer ribonucleic acid. |
Biochemistry |
942858 |
Rajbhandary UL |
Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA. |
Proc Natl Acad Sci U S A |
16591527 |
Thiebe R |
A specific modification next to the anticodon of phenylalanine transfer ribonucleic acid. |
Eur J Biochem |
5698615 |
Yoshikami D |
A fluorescence assay for phenylalanine transfer RNA. |
Biochim Biophys Acta |
5722700 |
Christian T |
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. |
RNA |
20980671 |
Lee C |
Yeast mitochondrial initiator tRNA is methylated at guanosine 37 by the Trm5-encoded tRNA (guanine-N1-)-methyltransferase. |
J Biol Chem |
17652090 |
Brule H |
Isolation and characterization of the human tRNA-(N1G37) methyltransferase (TRM5) and comparison to the Escherichia coli TrmD protein. |
Biochemistry |
15248782 |
Suzuki Y |
Structural basis of tRNA modification with CO2 fixation and methylation by wybutosine synthesizing enzyme TYW4. |
Nucleic Acids Res |
19287006 |
de Crecy-Lagard V |
Biosynthesis of wyosine derivatives in tRNA: an ancient and highly diverse pathway in Archaea. |
Mol Biol Evol |
20382657 |
Goto-Ito S |
Structure of an archaeal TYW1, the enzyme catalyzing the second step of wye-base biosynthesis. |
Acta Crystallogr D Biol Crystallogr |
17881823 |
Umitsu M |
Structural basis of AdoMet-dependent aminocarboxypropyl transfer reaction catalyzed by tRNA-wybutosine synthesizing enzyme, TYW2. |
Proc Natl Acad Sci U S A |
19717466 |
Phillips G |
Biosynthesis and function of tRNA modifications in Archaea. |
Curr Opin Microbiol |
21470902 |
Menezes S |
Formation of m2G6 in Methanocaldococcus jannaschii tRNA catalyzed by the novel methyltransferase Trm14. |
Nucleic Acids Res |
21693558 |
Mandal D |
Agmatidine, a modified cytidine in the anticodon of archaeal tRNA(Ile), base pairs with adenosine but not with guanosine. |
Proc Natl Acad Sci U S A |
20133752 |
Ikeuchi Y |
Agmatine-conjugated cytidine in a tRNA anticodon is essential for AUA decoding in archaea. |
Nat Chem Biol |
20139989 |
Osawa T |
Structural basis of tRNA agmatinylation essential for AUA codon decoding. |
Nat Struct Mol Biol |
22002223 |
Tollervey D |
The small nucleolar RNP protein NOP1 (fibrillarin) is required for pre-rRNA processing in yeast. |
EMBO J |
1825809 |
Jansen R |
A U3 snoRNP protein with homology to splicing factor PRP4 and G beta domains is required for ribosomal RNA processing. |
EMBO J |
8508778 |
Jansen RP |
Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast. |
J Cell Biol |
2026646 |
Baserga SJ |
An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs. |
EMBO J |
1714385 |
Yanagida M |
Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes. |
J Biol Chem |
14583623 |
Aris JP |
cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera. |
Proc Natl Acad Sci U S A |
1846968 |
Ye K |
Structural organization of box C/D RNA-guided RNA methyltransferase. |
Proc Natl Acad Sci U S A |
19666563 |
Lin J |
Structural basis for site-specific ribose methylation by box C/D RNA protein complexes. |
Nature |
21270896 |
Wang H |
Crystal structure of a fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. |
EMBO J |
10654930 |
Wang H |
Expression, purification and preliminary X-ray analysis of a fibrillarin homolog from Methanococcus jannaschii, a hyperthermophile. |
Acta Crystallogr D Biol Crystallogr |
10089444 |
Deng L |
Structure determination of fibrillarin from the hyperthermophilic archaeon Pyrococcus furiosus. |
Biochem Biophys Res Commun |
14975761 |
Oruganti S |
Alternative conformations of the archaeal Nop56/58-fibrillarin complex imply flexibility in box C/D RNPs. |
J Mol Biol |
17617422 |
Xue S |
Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. |
Mol Cell |
20864039 |
Aittaleb M |
Structural and thermodynamic evidence for a stabilizing role of Nop5p in S-adenosyl-L-methionine binding to fibrillarin. |
J Biol Chem |
15286083 |
Aittaleb M |
Structure and function of archaeal box C/D sRNP core proteins. |
Nat Struct Biol |
12598892 |
Suryadi J |
The crystal structure of the Methanocaldococcus jannaschii multifunctional L7Ae RNA-binding protein reveals an induced-fit interaction with the box C/D RNAs. |
Biochemistry |
16008351 |
Hamma T |
Structure of protein L7Ae bound to a K-turn derived from an archaeal box H/ACA sRNA at 1.8 A resolution. |
Structure |
15130481 |
Rozhdestvensky TS |
Binding of L7Ae protein to the K-turn of archaeal snoRNAs: a shared RNA binding motif for C/D and H/ACA box snoRNAs in Archaea. |
Nucleic Acids Res |
12560482 |
Moore T |
Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. |
Structure |
15130473 |
Biswas S |
Comparative analysis of the 15.5kD box C/D snoRNP core protein in the primitive eukaryote Giardia lamblia reveals unique structural and functional features. |
Biochemistry |
21366326 |
Vidovic I |
Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment. |
Mol Cell |
11163207 |
Liu S |
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP. |
Science |
17412961 |
Nottrott S |
Functional interaction of a novel 15.5kD [U4/U6.U5] tri-snRNP protein with the 5' stem-loop of U4 snRNA. |
EMBO J |
10545122 |
Ghalei H |
A novel Nop5-sRNA interaction that is required for efficient archaeal box C/D sRNP formation. |
RNA |
20962039 |
van Nues RW |
Box C/D snoRNP catalysed methylation is aided by additional pre-rRNA base-pairing. |
EMBO J |
21556049 |
Persson BC |
The ms2io6A37 modification of tRNA in Salmonella typhimurium regulates growth on citric acid cycle intermediates. |
J Bacteriol |
9620964 |
Nasvall SJ |
The wobble hypothesis revisited: uridine-5-oxyacetic acid is critical for reading of G-ending codons. |
RNA |
17942742 |
Lis AW |
Isolation of 5-hydroxyuridine (iso-barbituridine) from yeast ribonucleic acids. |
Arch Biochem Biophys |
5957714 |
Murao K |
5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis. |
Nucleic Acids Res |
825836 |
Lim K |
Crystal structure of YecO from Haemophilus influenzae (HI0319) reveals a methyltransferase fold and a bound S-adenosylhomocysteine. |
Proteins |
11746687 |
Pope WT |
The identification of the tRNA substrates for the supK tRNA methylase. |
Nucleic Acids Res |
347399 |
Ishikura H |
The presence of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]threonine in serine, methionine and lysine transfer RNA's from Escherichia coli. |
Biochem Biophys Res Commun |
4902784 |
Osawa T |
Conserved cysteine residues of GidA are essential for biogenesis of 5-carboxymethylaminomethyluridine at tRNA anticodon. |
Structure |
19446527 |
Meyer S |
Kissing G domains of MnmE monitored by X-ray crystallography and pulse electron paramagnetic resonance spectroscopy. |
PLoS Biol |
19806182 |
Yamanaka K |
Characterization of GTPase activity of TrmE, a member of a novel GTPase superfamily, from Thermotoga maritima. |
J Bacteriol |
11092873 |
Wang X |
Deletion of the MTO2 gene related to tRNA modification causes a failure in mitochondrial RNA metabolism in the yeast Saccharomyces cerevisiae. |
FEBS Lett |
17706197 |
Yan Q |
Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA. |
J Biol Chem |
15944150 |
Shi R |
Structural basis for Fe-S cluster assembly and tRNA thiolation mediated by IscS protein-protein interactions. |
PLoS Biol |
20404999 |
Ikeuchi Y |
Mechanistic insights into sulfur relay by multiple sulfur mediators involved in thiouridine biosynthesis at tRNA wobble positions. |
Mol Cell |
16387657 |
Katoh E |
High precision NMR structure of YhhP, a novel Escherichia coli protein implicated in cell division. |
J Mol Biol |
11080457 |
Numata T |
Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex. |
Structure |
16472754 |
Nakai Y |
Yeast Nfs1p is involved in thio-modification of both mitochondrial and cytoplasmic tRNAs. |
J Biol Chem |
14722066 |
Suzuki T |
Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases. |
Annu Rev Genet |
21910628 |
Suzuki T |
Human mitochondrial diseases caused by lack of taurine modification in mitochondrial tRNAs. |
Wiley Interdiscip Rev RNA |
21957023 |
Kimura S |
Base methylations in the double-stranded RNA by a fused methyltransferase bearing unwinding activity. |
Nucleic Acids Res |
22210896 |
Mikhailov SN |
Chemical incorporation of 1‑methyladenosine into oligonucleotides |
Nucl. Acids Res. |
11861902 |
Dewez M |
The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity. |
Proc Natl Acad Sci U S A |
18391219 |
Leidel S |
Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA. |
Nature |
19145231 |
Murao K |
Uridin-5-oxy acetic acid: a new minor constituent from E. coli valine transfer RNA I. |
Biochem Biophys Res Commun |
4910247 |
Karcher D |
Identification of the chloroplast adenosine-to-inosine tRNA editing enzyme. |
RNA |
19460869 |
Delannoy E |
Arabidopsis tRNA adenosine deaminase arginine edits the wobble nucleotide of chloroplast tRNAArg(ACG) and is essential for efficient chloroplast translation. |
Plant Cell |
19602623 |
Su AA |
A-to-I and C-to-U editing within transfer RNAs. |
Biochemistry (Mosc) |
22022967 |
Paris Z |
Determinants of tRNA editing and modification: Avoiding conundrums, affecting function. |
Semin Cell Dev Biol |
22024020 |
Randau L |
A cytidine deaminase edits C to U in transfer RNAs in Archaea. |
Science |
19407206 |
Hamdane D |
Insights into folate/FAD-dependent tRNA methyltransferase mechanism: role of two highly conserved cysteines in catalysis. |
J Biol Chem |
21846722 |
Hamdane D |
A catalytic intermediate and several flavin redox states stabilized by folate-dependent tRNA methyltransferase from Bacillus subtilis. |
Biochemistry |
21561081 |
Hamdane D |
Expression and purification of untagged and histidine-tagged folate-dependent tRNA:m5U54 methyltransferase from Bacillus subtilis. |
Protein Expr Purif |
20412857 |
Haumont E |
Enzymatic formation of queuosine and of glycosyl queuosine in yeast tRNAs microinjected into Xenopus laevis oocytes. The effect of the anticodon loop sequence. |
Eur J Biochem |
3117541 |
Nishimura S |
Structure, biosynthesis, and function of queuosine in transfer RNA. |
Prog Nucleic Acid Res Mol Biol |
6410456 |
Okada N |
Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver. |
Nucleic Acids Res |
20603 |
Costa A |
Determination of queuosine derivatives by reverse-phase liquid chromatography for the hypomodification study of Q-bearing tRNAs from various mammal liver cells. |
J Chromatogr B Analyt Technol Biomed Life Sci |
14751792 |
Kasai H |
Letter: The structure of Q* nucleoside isolated from rabbit liver transfer ribonucleic acid. |
J Am Chem Soc |
950430 |
Nishimasu H |
Atomic structure of a folate/FAD-dependent tRNA T54 methyltransferase. |
Proc Natl Acad Sci U S A |
19416846 |
Li S |
Reconstitution and structural analysis of the yeast box H/ACA RNA-guided pseudouridine synthase. |
Genes Dev |
22085967 |
Piekna-Przybylska D |
New bioinformatic tools for analysis of nucleotide modifications in eukaryotic rRNA. |
RNA |
17283215 |
Li S |
Structure of the Shq1-Cbf5-Nop10-Gar1 complex and implications for H/ACA RNP biogenesis and dyskeratosis congenita. |
EMBO J |
22117216 |
Khanna M |
Structural study of the H/ACA snoRNP components Nop10p and the 3' hairpin of U65 snoRNA. |
RNA |
16373493 |
Kiss T |
Box H/ACA small ribonucleoproteins. |
Mol Cell |
20227365 |
Hamma T |
The box H/ACA ribonucleoprotein complex: interplay of RNA and protein structures in post-transcriptional RNA modification. |
J Biol Chem |
19917616 |
Spears JL |
A single zinc ion is sufficient for an active Trypanosoma brucei tRNA editing deaminase. |
J Biol Chem |
21507956 |
Ragone FL |
The C-terminal end of the Trypanosoma brucei editing deaminase plays a critical role in tRNA binding. |
RNA |
21602302 |
Rubio MA |
An adenosine-to-inosine tRNA-editing enzyme that can perform C-to-U deamination of DNA. |
Proc Natl Acad Sci U S A |
17483465 |
Bjork GR |
A novel link between the biosynthesis of aromatic amino acids and transfer RNA modification in Escherichia coli. |
J Mol Biol |
6160251 |
Chatterjee K |
The archaeal COG1901/DUF358 SPOUT-methyltransferase members, together with pseudouridine synthase Pus10, catalyze the formation of 1-methylpseudouridine at position 54 of tRNA. |
RNA |
22274953 |
Wurm JP |
Identification of the enzyme responsible for N1-methylation of pseudouridine 54 in archaeal tRNAs. |
RNA |
22274954 |
Chen HY |
Crystal structure of Mj1640/DUF358 protein reveals a putative SPOUT-class RNA methyltransferase. |
J Mol Cell Biol |
21098051 |
Suzuki T |
Discovery and characterization of tRNAIle lysidine synthetase (TilS). |
FEBS Lett |
19944692 |
Fabret C |
Life without the essential bacterial tRNA Ile2-lysidine synthetase TilS: a case of tRNA gene recruitment in Bacillus subtilis. |
Mol Microbiol |
21435031 |
Terasaka N |
Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS. |
Nat Struct Mol Biol |
22002222 |
Shigi N |
Common thiolation mechanism in the biosynthesis of tRNA thiouridine and sulphur-containing cofactors. |
EMBO J |
19037260 |
Shigi N |
Identification of two tRNA thiolation genes required for cell growth at extremely high temperatures. |
J Biol Chem |
16547008 |
Palenchar PM |
Evidence that ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis, may be a sulfurtransferase that proceeds through a persulfide intermediate. |
J Biol Chem |
10722656 |
Kambampati R |
Evidence for the transfer of sulfane sulfur from IscS to ThiI during the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. |
J Biol Chem |
10753862 |
Mueller EG |
The role of the cysteine residues of ThiI in the generation of 4-thiouridine in tRNA. |
J Biol Chem |
11443125 |
Wright CM |
A paradigm for biological sulfur transfers via persulfide groups: a persulfide-disulfide-thiol cycle in 4-thiouridine biosynthesis. |
Chem Commun (Camb) |
12510310 |
Tanaka Y |
Deduced RNA binding mechanism of ThiI based on structural and binding analyses of a minimal RNA ligand. |
RNA |
19509301 |
You D |
Direct evidence that ThiI is an ATP pyrophosphatase for the adenylation of uridine in 4-thiouridine biosynthesis. |
Chembiochem |
18604845 |
Wright CM |
Direct evidence for enzyme persulfide and disulfide intermediates during 4-thiouridine biosynthesis. |
Chem Commun (Camb) |
16855700 |
Cantara WA |
Modifications Modulate Anticodon Loop Dynamics and Codon Recognition of E. coli tRNA(Arg1,2). |
J Mol Biol |
22240457 |
Carbon J |
Thiobases in Escherchia coli Transfer RNA: 2-Thiocytosine and 5-Methylaminomethyl-2-thiouracil. |
Science |
17812290 |
Fontecave M |
Iron-sulfur cluster biosynthesis in bacteria: Mechanisms of cluster assembly and transfer. |
Arch Biochem Biophys |
18191630 |
Bjork GR |
A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast. |
RNA |
17592039 |
Leulliot N |
The yeast ribosome synthesis factor Emg1 is a novel member of the superfamily of alpha/beta knot fold methyltransferases. |
Nucleic Acids Res |
18063569 |
Lee HH |
Overexpression, crystallization and preliminary X-ray crystallographic analysis of Pseudomonas aeruginosa MnmE, a GTPase involved in tRNA modification. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
20693664 |
Chimnaronk S |
RNA helicase module in an acetyltransferase that modifies a specific tRNA anticodon. |
EMBO J |
19322199 |
Porcher S. |
Synthesis of 2′-O-[(Triisopropylsilyl)oxy]methyl (= tom)-Protected Ribonucleoside Phosphoramidites Containing Various Nucleobase Analogues |
HELVETICA CHIMICA ACTA |
10.1002/hlca.200590209 |
Agris PF. |
Site-selected introduction of modified purine and pyrimidine ribonucleosides into RNA by automated phosphoramidite chemistry. |
Biochimie |
7599270 |
Höbartner, C |
The synthesis of 2'-O-[(Triisopropylsilyl)oxy] methyl (TOM) phosphoramidites of methylated ribonucleosides (m1G, m2G, m22G, m1I, m3U, m4C, m6A, m62A) for use in automated RNA solid-phase synthesis |
Monatshefte fuer Chemie |
|
Boudou V. |
Synthesis of the Anticodon Hairpin tRNAfMet Containing N-{[9-(β-D-Ribofuranosyl)-9H-purin-6-yl]carbamoyl}-L-threonine (=N6-{{[(1S,2R)-1-Carboxy-2-hydroxypropyl]amino}carbonyl}adenosine, t6A) |
Helvetica Chimica Acta |
10.1002/(SICI)1522-2675(20000119)83:1<152::AID-HLC |
Clarke L |
The nucleotide sequence of a threonine transfer ribonucleic acid from Escherichia coli. |
J Biol Chem |
4608712 |
Komine Y |
Nucleotide sequence of tRNA(Thr1) of Escherichia coli and of the gene (thrV) that encodes it. |
Nucleic Acids Res |
1380693 |
Mallikarjun Sundaram |
Synthesis and Characterization of the Native Anticodon Domain of E. coli tRNALys: Simultaneous Incorporation of Modified Nucleosides mnm5s2U, t6A, and Pseudouridine Using Phosphoramidite Chemistry |
J. Org. Chem. |
10970299 |
Bajji AC |
Synthesis of the tRNALys,3 Anticodon Stem-Loop Domain Containing the Hypermodified ms2t6A Nucleoside |
J. Org. Chem |
12126427 |
Jasenka Matulic-Adamic |
An Improved Synthesis of Inosine 3′-Phosphoramidite |
SYNTHETIC COMMUNICATIONS |
10.1080/00397910008086956 |
Chui HM |
Synthesis of a 3-methyluridine phosphoramidite to investigate the role of methylation in a ribosomal RNA hairpin. |
Bioorg Med Chem |
11741781 |
Chui HM |
Synthesis of helix 69 of Escherichia coli 23S rRNA containing its natural modified nucleosides, m(3)Psi and Psi. |
J Org Chem |
12467398 |
O'Connor M |
Mutagenesis of the peptidyltransferase center of 23S rRNA: the invariant U2449 is dispensable. |
Nucleic Acids Res |
11160893 |
Kumar RK |
Synthesis and studies on the effect of 2-thiouridine and 4-thiouridine on sugar conformation and RNA duplex stability. |
Nucleic Acids Res |
9092639 |
Chaix C |
Solid phase synthesis of the 5'-half of the initiator t-RNA from B. subtilis. |
Nucleic Acids Res |
2508060 |
Shibahara S |
Site-directed cleavage of RNA. |
Nucleic Acids Res |
2438655 |
Inoue H |
Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides. |
Nucleic Acids Res |
3627981 |
Beier M |
Synthesis of N-Methylated Ribonucleosides for RNA Synthesis |
Helvetica Chimica Acta |
10.1002/hlca.200390205 |
Kierzek E |
The synthesis of oligoribonucleotides containing N6-alkyladenosines and 2-methylthio-N6-alkyladenosines via post-synthetic modification of precursor oligomers. |
Nucleic Acids Res |
12888506 |
Davis DR |
Introduction of hypermodified nucleotides in RNA. |
Methods Mol Biol |
15333904 |
Rossa B. S. |
Synthesis and Incorporation of 2′-O-Methyl-Pseudouridine into Oligonucleotides |
Nucleosides and Nucleotides |
10.1080/07328319708006226 |
Pieles U. |
New and convenient protection system for pseudouridine, highly suitable for solid-phase oligoribonucleotide synthesis |
J. Chem. Soc. |
10.1039/P19940003423 |
Gasparutto D |
Chemical synthesis of a biologically active natural tRNA with its minor bases. |
Nucleic Acids Res |
1383941 |
Ogata |
Chemical synthesis of RNA including 5-taurinomethyluridine |
Nucleic Acids Symposium |
10.1093/nass/nrl005 |
Meroueh M |
Unique structural and stabilizing roles for the individual pseudouridine residues in the 1920 region of Escherichia coli 23S rRNA. |
Nucleic Acids Res |
10773075 |
Kowtoniuk WE |
A chemical screen for biological small molecule-RNA conjugates reveals CoA-linked RNA. |
Proc Natl Acad Sci U S A |
19416889 |
Chen YG |
LC/MS analysis of cellular RNA reveals NAD-linked RNA. |
Nat Chem Biol |
19820715 |
Kato N |
Nucleotide sequence of nuclear 5.4 S RNA of mouse cells. |
Biochim Biophys Acta |
6202321 |
Mao X |
Mutational analysis of the Saccharomyces cerevisiae ABD1 gene: cap methyltransferase activity is essential for cell growth. |
Mol Cell Biol |
8552073 |
Wang SP |
Structure-function analysis of the mRNA cap methyltransferase of Saccharomyces cerevisiae. |
J Biol Chem |
9169431 |
Schroeder SC |
Dynamic association of capping enzymes with transcribing RNA polymerase II. |
Genes Dev |
11018011 |
Bellemer C |
Genetic interactions show the importance of rRNA modification machinery for the role of Rps15p during ribosome biogenesis in S. cerevisiae. |
PLoS One |
20454621 |
Figaro S |
Trm112 Is Required for Bud23-Mediated Methylation of the 18S rRNA at Position G1575. |
Mol Cell Biol |
22493060 |
Yamagishi M |
Isolation of temperature-sensitive mutants for mRNA capping enzyme in Saccharomyces cerevisiae. |
Mol Gen Genet |
7500935 |
Itoh N |
Messenger RNA guanylyltransferase from Saccharomyces cerevisiae. Large scale purification, subunit functions, and subcellular localization. |
J Biol Chem |
3029058 |
Gu M |
Structure of the Saccharomyces cerevisiae Cet1-Ceg1 mRNA capping apparatus. |
Structure |
20159466 |
Takase Y |
The essential interaction between yeast mRNA capping enzyme subunits is not required for triphosphatase function in vivo. |
Mol Cell Biol |
11094081 |
Savage DF |
Molecular determinants of dihydrouridine synthase activity. |
FEBS Lett |
16962594 |
Blaise M |
Crystal structure of glutamyl-queuosine tRNAAsp synthetase complexed with L-glutamate: structural elements mediating tRNA-independent activation of glutamate and glutamylation of tRNAAsp anticodon. |
J Mol Biol |
18602926 |
Huang Y |
Structural insights into mechanisms of the small RNA methyltransferase HEN1. |
Nature |
19812675 |
Vilkaitis G |
Kinetic and functional analysis of the small RNA methyltransferase HEN1: the catalytic domain is essential for preferential modification of duplex RNA. |
RNA |
20705645 |
Li J |
Methylation protects miRNAs and siRNAs from a 3'-end uridylation activity in Arabidopsis. |
Curr Biol |
16111943 |
Yu B |
Methylation as a crucial step in plant microRNA biogenesis. |
Science |
15705854 |
Yu B |
siRNAs compete with miRNAs for methylation by HEN1 in Arabidopsis. |
Nucleic Acids Res |
20448024 |
Yang Z |
HEN1 recognizes 21-24 nt small RNA duplexes and deposits a methyl group onto the 2' OH of the 3' terminal nucleotide. |
Nucleic Acids Res |
16449203 |
Bodi Z |
Yeast targets for mRNA methylation. |
Nucleic Acids Res |
20421205 |
Chimnaronk S |
Snapshots of dynamics in synthesizing N(6)-isopentenyladenosine at the tRNA anticodon. |
Biochemistry |
19435325 |
Seif E |
RNA-protein mutually induced fit: structure of Escherichia coli isopentenyl-tRNA transferase in complex with tRNA(Phe). |
J Biol Chem |
19158097 |
Moore JA |
Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: a binding mechanism for recombinant enzyme. |
Biochemistry |
9012675 |
Pierrel F |
Enzymatic modification of tRNAs: MiaB is an iron-sulfur protein. |
J Biol Chem |
11882645 |
Waller JC |
Evidence that the folate-dependent proteins YgfZ and MnmEG have opposing effects on growth and on activity of the iron-sulfur enzyme MiaB. |
J Bacteriol |
22081392 |
Anantharaman V |
TRAM, a predicted RNA-binding domain, common to tRNA uracil methylation and adenine thiolation enzymes. |
FEMS Microbiol Lett |
11313137 |
Armengod ME |
Enzymology of tRNA modification in the bacterial MnmEG pathway. |
Biochimie |
22386868 |
Tolerico LH |
Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations. |
Genetics |
9872948 |
Lamichhane TN |
Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases. |
RNA |
21873461 |
Feder M |
Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. |
Gene |
12527203 |
Sirum-Connolly K |
Implications of a functional large ribosomal RNA with only three modified nucleotides. |
Biochimie |
7541254 |
Noma A |
Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions. |
Nucleic Acids Res |
19151091 |
Huang B |
A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. |
RNA |
18755837 |
Nakai Y |
Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems. |
J Biol Chem |
18664566 |
Thomas SR |
Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis. |
Nucleic Acids Res |
21087996 |
Brand RC |
Biosynthesis of a hypermodified nucleotide in Saccharomyces carlsbergensis 17S and HeLa-cell 18S ribosomal ribonucleic acid. |
Biochem J |
629754 |
Pavlopoulou A |
Phylogenetic analysis of the eukaryotic RNA (cytosine-5)-methyltransferases. |
Genomics |
19135144 |
King MY |
RNA methyltransferases utilize two cysteine residues in the formation of 5-methylcytosine. |
Biochemistry |
12220187 |
Yang C |
Psi35 in the branch site recognition region of U2 small nuclear RNA is important for pre-mRNA splicing in Saccharomyces cerevisiae. |
J Biol Chem |
15611063 |
Lin Y |
X-ray structures of U2 snRNA-branchpoint duplexes containing conserved pseudouridines. |
Biochemistry |
18435545 |
Decatur WA |
Different mechanisms for pseudouridine formation in yeast 5S and 5.8S rRNAs. |
Mol Cell Biol |
18332121 |
Urban A |
RNA sequence and two-dimensional structure features required for efficient substrate modification by the Saccharomyces cerevisiae RNA:{Psi}-synthase Pus7p. |
J Biol Chem |
19114708 |
Reader JS |
Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. |
J Biol Chem |
14660578 |
Liu M |
Methylation of 23S rRNA nucleotide G745 is a secondary function of the RlmAI methyltransferase. |
RNA |
15388872 |
Persaud C |
Mutagenesis of the modified bases, m(5)U1939 and psi2504, in Escherichia coli 23S rRNA. |
Biochem Biophys Res Commun |
20067766 |
Osterman IA |
Methylated 23S rRNA nucleotide m2G1835 of Escherichia coli ribosome facilitates subunit association. |
Biochimie |
21237242 |
Ero R |
Identification of pseudouridine methyltransferase in Escherichia coli. |
RNA |
18755836 |
Ero R |
Specificity and kinetics of 23S rRNA modification enzymes RlmH and RluD. |
RNA |
20817755 |
Motorin Y |
5-methylcytosine in RNA: detection, enzymatic formation and biological functions. |
Nucleic Acids Res |
20007150 |
Wang KT |
Structure of the bifunctional methyltransferase YcbY (RlmKL) that adds the m7G2069 and m2G2445 modifications in Escherichia coli 23S rRNA. |
Nucleic Acids Res |
22362734 |
Zhang Q |
Radical-mediated enzymatic methylation: a tale of two SAMS. |
Acc Chem Res |
22097883 |
Grove TL |
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation. |
J Am Chem Soc |
21916495 |
Ofengand J |
Pseudouridines and pseudouridine synthases of the ribosome. |
Cold Spring Harb Symp Quant Biol |
12762017 |
Mizutani K |
Crystal structures of the catalytic domains of pseudouridine synthases RluC and RluD from Escherichia coli. |
Biochemistry |
15078091 |
Huang L |
Identification of two Escherichia coli pseudouridine synthases that show multisite specificity for 23S RNA. |
Biochemistry |
9843401 |
Del Campo M |
Crystal structure of the catalytic domain of RluD, the only rRNA pseudouridine synthase required for normal growth of Escherichia coli. |
RNA |
14730022 |
Leppik M |
Substrate specificity of the pseudouridine synthase RluD in Escherichia coli. |
FEBS J |
17937767 |
Sivaraman J |
Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli. |
J Mol Biol |
14659742 |
Alian A |
Crystal structure of an RluF-RNA complex: a base-pair rearrangement is the key to selectivity of RluF for U2604 of the ribosome. |
J Mol Biol |
19298824 |
Schmitt E |
Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases. |
J Mol Biol |
19303884 |
Boehringer D |
Structural insights into methyltransferase KsgA function in 30S ribosomal subunit biogenesis. |
J Biol Chem |
22308031 |
Desai PM |
Site-directed mutants of 16S rRNA reveal important RNA domains for KsgA function and 30S subunit assembly. |
Biochemistry |
21142019 |
Connolly K |
Mechanistic insight into the ribosome biogenesis functions of the ancient protein KsgA. |
Mol Microbiol |
18990185 |
O'Farrell HC |
Control of substrate specificity by a single active site residue of the KsgA methyltransferase. |
Biochemistry |
22142337 |
Poldermans B |
Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. III. Purification and properties of the methylating enzyme and methylase-30 S interactions. |
J Biol Chem |
383712 |
Poldermans B |
Studies on the function of two adjacent N6,N6-dimethyladenosines near the 3' end of 16S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction. |
Nucleic Acids Res |
6986611 |
Lafontaine D |
The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast. |
J Mol Biol |
8064863 |
Park AK |
Comprehensive phylogenetic analysis of evolutionarily conserved rRNA adenine dimethyltransferase suggests diverse bacterial contributions to the nucleus-encoded plastid proteome. |
Mol Phylogenet Evol |
19017544 |
Vanrobays E |
Dim2p, a KH-domain protein required for small ribosomal subunit synthesis. |
RNA |
15037774 |
Lafontaine DL |
Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? |
Mol Cell Biol |
9528805 |
Weitzmann C |
A paradigm for local conformational control of function in the ribosome: binding of ribosomal protein S19 to Escherichia coli 16S rRNA in the presence of S7 is required for methylation of m2G966 and blocks methylation of m5C967 by their respective methyltransferases. |
Nucleic Acids Res |
1766869 |
Sergeeva OV |
Properties of small rRNA methyltransferase RsmD: Mutational and kinetic study. |
RNA |
22535590 |
Cubrilo S |
The aminoglycoside resistance methyltransferase Sgm impedes RsmF methylation at an adjacent rRNA nucleotide in the ribosomal A site. |
RNA |
19509304 |
Benitez-Paez A |
Regulation of expression and catalytic activity of Escherichia coli RsmG methyltransferase. |
RNA |
22337945 |
Mikheil DM |
Deletion of gene encoding methyltransferase (gidB) confers high-level antimicrobial resistance in Salmonella. |
J Antibiot (Tokyo) |
22318332 |
Guymon R |
Influence of phylogeny on posttranscriptional modification of rRNA in thermophilic prokaryotes: the complete modification map of 16S rRNA of Thermus thermophilus. |
Biochemistry |
16605256 |
Sivaraman J |
Structure of the 16S rRNA pseudouridine synthase RsuA bound to uracil and UMP. |
Nat Struct Biol |
11953756 |
El Yacoubi B |
The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA. |
Nucleic Acids Res |
19287007 |
Lin CA |
The Sua5 protein is essential for normal translational regulation in yeast. |
Mol Cell Biol |
19884342 |
Jackman JE |
Doing it in reverse: 3'-to-5' polymerization by the Thg1 superfamily. |
RNA |
22456265 |
Ozanick SG |
Conserved amino acids in each subunit of the heteroligomeric tRNA m1A58 Mtase from Saccharomyces cerevisiae contribute to tRNA binding. |
Nucleic Acids Res |
17932071 |
Guelorget A |
Structural comparison of tRNA m(1)A58 methyltransferases revealed different molecular strategies to maintain their oligomeric architecture under extreme conditions. |
BMC Struct Biol |
22168821 |
Sasarman F |
The 2-thiouridylase function of the human MTU1 (TRMU) enzyme is dispensable for mitochondrial translation. |
Hum Mol Genet |
21890497 |
Harris KA |
YrdC exhibits properties expected of a subunit for a tRNA threonylcarbamoyl transferase. |
RNA |
21775474 |
Deutsch C |
Biosynthesis of threonylcarbamoyl adenosine (t6A), a universal tRNA nucleoside. |
J Biol Chem |
22378793 |
Brachat A |
Analysis of deletion phenotypes and GFP fusions of 21 novel Saccharomyces cerevisiae open reading frames. |
Yeast |
10649453 |
Ishitani R |
Crystal structure of archaeosine tRNA-guanine transglycosylase. |
J Mol Biol |
12054814 |
Ishitani R |
Alternative tertiary structure of tRNA for recognition by a posttranscriptional modification enzyme. |
Cell |
12732145 |
Christian T |
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. |
Biochemistry |
16768442 |
Goto-Ito S |
Tertiary structure checkpoint at anticodon loop modification in tRNA functional maturation. |
Nat Struct Mol Biol |
19749755 |
Kuratani M |
Crystal structure and mutational study of a unique SpoU family archaeal methylase that forms 2'-O-methylcytidine at position 56 of tRNA. |
J Mol Biol |
18068186 |
Renalier MH |
The Cm56 tRNA modification in archaea is catalyzed either by a specific 2'-O-methylase, or a C/D sRNP. |
RNA |
15987815 |
Walbott H |
The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity. |
Nucleic Acids Res |
18653523 |
Urbonavicius J |
Acquisition of a bacterial RumA-type tRNA(uracil-54, C5)-methyltransferase by Archaea through an ancient horizontal gene transfer. |
Mol Microbiol |
18069966 |
Hecker A |
The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. |
Biochem Soc Trans |
19143597 |
Haile JD |
The activity of an ancient atypical protein kinase is stimulated by ADP-ribose in vitro. |
Arch Biochem Biophys |
21527241 |
Facchin S |
Structure-function analysis of yeast piD261/Bud32, an atypical protein kinase essential for normal cell life. |
Biochem J |
12023889 |
Henras AK |
Cbf5p, the putative pseudouridine synthase of H/ACA-type snoRNPs, can form a complex with Gar1p and Nop10p in absence of Nhp2p and box H/ACA snoRNAs. |
RNA |
15388873 |
Liang B |
Structure of a functional ribonucleoprotein pseudouridine synthase bound to a substrate RNA. |
Nat Struct Mol Biol |
19478803 |
Mao DY |
Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine. |
Mol Cell |
18951093 |
Downey M |
A genome-wide screen identifies the evolutionarily conserved KEOPS complex as a telomere regulator. |
Cell |
16564010 |
Jain R |
Active site mapping and substrate specificity of bacterial Hen1, a manganese-dependent 3' terminal RNA ribose 2'O-methyltransferase. |
RNA |
21205839 |
Mui Chan C |
Structural and biochemical insights into 2'-O-methylation at the 3'-terminal nucleotide of RNA by Hen1. |
Proc Natl Acad Sci U S A |
19822745 |
Jain R |
Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. |
RNA |
20007328 |
Zhang C |
Probing the substrate specificity of the bacterial Pnkp/Hen1 RNA repair system using synthetic RNAs. |
RNA |
22190744 |
Chan CM |
Reconstituting bacterial RNA repair and modification in vitro. |
Science |
19815768 |
Hecker A |
An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro. |
Nucleic Acids Res |
17766251 |
Srinivasan M |
The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. |
EMBO J |
21183954 |
El Yacoubi B |
A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification. |
EMBO J |
21285948 |
Daugeron MC |
Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs. |
Nucleic Acids Res |
21459853 |
Hecker A |
Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. |
EMBO J |
19172740 |
Anton BP |
Functional characterization of the YmcB and YqeV tRNA methylthiotransferases of Bacillus subtilis. |
Nucleic Acids Res |
20472640 |
Hernandez HL |
MiaB, a bifunctional radical-S-adenosylmethionine enzyme involved in the thiolation and methylation of tRNA, contains two essential [4Fe-4S] clusters. |
Biochemistry |
17407324 |
Pierrel F |
MiaB protein from Thermotoga maritima. Characterization of an extremely thermophilic tRNA-methylthiotransferase. |
J Biol Chem |
12766153 |
Atta M |
S-Adenosylmethionine-dependent radical-based modification of biological macromolecules. |
Curr Opin Struct Biol |
20951571 |
Golovko A |
Identification of a tRNA isopentenyltransferase gene from Arabidopsis thaliana. |
Plant Mol Biol |
11999372 |
Miyawaki K |
Roles of Arabidopsis ATP/ADP isopentenyltransferases and tRNA isopentenyltransferases in cytokinin biosynthesis. |
Proc Natl Acad Sci U S A |
17062755 |
Golovko A |
Cloning of a human tRNA isopentenyl transferase. |
Gene |
11111046 |
Arragain S |
Identification of eukaryotic and prokaryotic methylthiotransferase for biosynthesis of 2-methylthio-N6-threonylcarbamoyladenosine in tRNA. |
J Biol Chem |
20584901 |
Wei FY |
Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. |
J Clin Invest |
21841312 |
Wurm JP |
Backbone resonance assignments of the 48 kDa dimeric putative 18S rRNA-methyltransferase Nep1 from Methanocaldococcus jannaschii. |
Biomol NMR Assign |
19779849 |
Wurm JP |
The ribosome assembly factor Nep1 responsible for Bowen-Conradi syndrome is a pseudouridine-N1-specific methyltransferase. |
Nucleic Acids Res |
20047967 |
Auxilien S |
Specificity shifts in the rRNA and tRNA nucleotide targets of archaeal and bacterial m5U methyltransferases. |
RNA |
21051506 |
Oberto J |
Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance. |
Nucleic Acids Res |
19578062 |
Douthwaite S |
Interaction of the tylosin-resistance methyltransferase RlmA II at its rRNA target differs from the orthologue RlmA I. |
J Mol Biol |
18406425 |
Lebars I |
Recognition elements in rRNA for the tylosin resistance methyltransferase RlmA(II). |
J Mol Biol |
17673230 |
Douthwaite S |
The tylosin-resistance methyltransferase RlmA(II) (TlrB) modifies the N-1 position of 23S rRNA nucleotide G748. |
J Mol Biol |
15046978 |
Desmolaize B |
A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA. |
Nucleic Acids Res |
21824914 |
Niu L |
Cloning and characterization of the 23S RNA pseudouridine 2633 synthase from Bacillus subtilis. |
Biochemistry |
9888802 |
Tu C |
Structural basis for binding of RNA and cofactor by a KsgA methyltransferase. |
Structure |
19278652 |
Richter U |
A mitochondrial rRNA dimethyladenosine methyltransferase in Arabidopsis. |
Plant J |
19929881 |
Cotney J |
Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2. |
J Mol Evol |
17031457 |
O'Farrell HC |
Binding of adenosine-based ligands to the MjDim1 rRNA methyltransferase: implications for reaction mechanism and drug design. |
Biochemistry |
20163168 |
Demirci H |
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine. |
J Mol Biol |
19285505 |
Ochi K |
Inactivation of KsgA, a 16S rRNA methyltransferase, causes vigorous emergence of mutants with high-level kasugamycin resistance. |
Antimicrob Agents Chemother |
19001112 |
Demirci H |
Multi-site-specific 16S rRNA methyltransferase RsmF from Thermus thermophilus. |
RNA |
20558545 |
Demirci H |
Crystal structure of the Thermus thermophilus 16 S rRNA methyltransferase RsmC in complex with cofactor and substrate guanosine. |
J Biol Chem |
18667428 |
Kumar A |
Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition. |
J Biol Chem |
21474448 |
Gregory ST |
Structural and functional studies of the Thermus thermophilus 16S rRNA methyltransferase RsmG. |
RNA |
19622680 |
Kuratani M |
Crystal structure of Sulfolobus tokodaii Sua5 complexed with L-threonine and AMPPNP. |
Proteins |
21538543 |
Agari Y |
X-ray crystal structure of a hypothetical Sua5 protein from Sulfolobus tokodaii strain 7. |
Proteins |
18004774 |
Kuratani M |
Crystal structure of tRNA adenosine deaminase (TadA) from Aquifex aeolicus. |
J Biol Chem |
15677468 |
Losey HC |
Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA. |
Nat Struct Mol Biol |
16415880 |
Reuter K |
Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme. |
J Bacteriol |
7665516 |
Romier C |
Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange. |
EMBO J |
8654383 |
Gradler U |
Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity. |
FEBS Lett |
10413112 |
Awai T |
Substrate tRNA recognition mechanism of a multisite-specific tRNA methyltransferase, Aquifex aeolicus Trm1, based on the X-ray crystal structure. |
J Biol Chem |
21844194 |
Awai T |
Aquifex aeolicus tRNA (N2,N2-guanine)-dimethyltransferase (Trm1) catalyzes transfer of methyl groups not only to guanine 26 but also to guanine 27 in tRNA. |
J Biol Chem |
19491098 |
Ihsanawati |
Crystal structure of tRNA N2,N2-guanosine dimethyltransferase Trm1 from Pyrococcus horikoshii. |
J Mol Biol |
18789948 |
Kuratani M |
Crystal structure of Methanocaldococcus jannaschii Trm4 complexed with sinefungin. |
J Mol Biol |
20600111 |
Gabant G |
THUMP from archaeal tRNA:m22G10 methyltransferase, a genuine autonomously folding domain. |
Nucleic Acids Res |
16687654 |
Armengaud J |
N2-methylation of guanosine at position 10 in tRNA is catalyzed by a THUMP domain-containing, S-adenosylmethionine-dependent methyltransferase, conserved in Archaea and Eukaryota. |
J Biol Chem |
15210688 |
Benitez-Paez A |
YibK is the 2'-O-methyltransferase TrmL that modifies the wobble nucleotide in Escherichia coli tRNA(Leu) isoacceptors. |
RNA |
20855540 |
Roovers M |
The open reading frame TTC1157 of Thermus thermophilus HB27 encodes the methyltransferase forming N(2)-methylguanosine at position 6 in tRNA. |
RNA |
22337946 |
Phannachet K |
Conformational change of pseudouridine 55 synthase upon its association with RNA substrate. |
Nucleic Acids Res |
14990747 |
Handford JI |
Conserved network of proteins essential for bacterial viability. |
J Bacteriol |
19376873 |
Hashimoto C |
Effects on transcription of mutations in ygjD, yeaZ, and yjeE genes, which are involved in a universal tRNA modification in Escherichia coli. |
J Bacteriol |
21873492 |
Aydin I |
Structural analysis of the essential resuscitation promoting factor YeaZ suggests a mechanism of nucleotide regulation through dimer reorganization. |
PLoS One |
21858042 |
Xu Q |
Structure of an essential bacterial protein YeaZ (TM0874) from Thermotoga maritima at 2.5 A resolution. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
20944216 |
Fu TM |
The structure of the hypothetical protein smu.1377c from Streptococcus mutans suggests a role in tRNA modification. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
20606270 |
Karst JC |
The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. |
Microbiology |
19246765 |
Mangat CS |
Known bioactive small molecules probe the function of a widely conserved but enigmatic bacterial ATPase, YjeE. |
Chem Biol |
19101473 |
Brown ED |
Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. |
Biochem Cell Biol |
16333325 |
Qian Q |
The methyl group of the N6-methyl-N6-threonylcarbamoyladenosine in tRNA of Escherichia coli modestly improves the efficiency of the tRNA. |
J Bacteriol |
9537379 |
Phillips G |
Biosynthesis of 7-deazaguanosine-modified tRNA nucleosides: a new role for GTP cyclohydrolase I. |
J Bacteriol |
18931107 |
McCarty RM |
The deazapurine biosynthetic pathway revealed: in vitro enzymatic synthesis of PreQ(0) from guanosine 5'-triphosphate in four steps. |
Biochemistry |
19354300 |
Gaur R |
Genetic analysis identifies a function for the queC (ybaX) gene product at an initial step in the queuosine biosynthetic pathway in Escherichia coli. |
J Bacteriol |
16199558 |
Cicmil N |
Crystal structure of QueC from Bacillus subtilis: an enzyme involved in preQ1 biosynthesis. |
Proteins |
18491386 |
McCarty RM |
Escherichia coli QueD is a 6-carboxy-5,6,7,8-tetrahydropterin synthase. |
Biochemistry |
19231875 |
Phillips G |
Functional promiscuity of the COG0720 family. |
ACS Chem Biol |
21999246 |
Cicmil N |
Crystallization and preliminary X-ray characterization of queD from Bacillus subtilis, an enzyme involved in queuosine biosynthesis. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
18259064 |
Sekiya T |
Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells. |
J Biol Chem |
14660579 |
Lee BW |
Mechanistic studies of Bacillus subtilis QueF, the nitrile oxidoreductase involved in queuosine biosynthesis. |
Biochemistry |
17929836 |
Droogmans L |
Cloning and characterization of tRNA (m1A58) methyltransferase (TrmI) from Thermus thermophilus HB27, a protein required for cell growth at extreme temperatures. |
Nucleic Acids Res |
12682365 |
Barraud P |
Crystal structure of Thermus thermophilus tRNA m1A58 methyltransferase and biophysical characterization of its interaction with tRNA. |
J Mol Biol |
18262540 |
Varshney U |
Mycobacterium tuberculosis Rv2118c codes for a single-component homotetrameric m1A58 tRNA methyltransferase. |
Nucleic Acids Res |
14960715 |
Gupta A |
Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv. |
J Mol Biol |
11554794 |
Pastore C |
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodification. |
J Biol Chem |
22065580 |
Fu D |
Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. |
Mol Cell Biol |
20308323 |
van den Born E |
ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA. |
Nat Commun |
21285950 |
Fu Y |
The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. |
Angew Chem Int Ed Engl |
20583019 |
Noma A |
Actin-binding protein ABP140 is a methyltransferase for 3-methylcytidine at position 32 of tRNAs in Saccharomyces cerevisiae. |
RNA |
21518805 |
D'Silva S |
A domain of the actin binding protein Abp140 is the yeast methyltransferase responsible for 3-methylcytidine modification in the tRNA anti-codon loop. |
RNA |
21518804 |
Zegers I |
Crystal structure of Bacillus subtilis TrmB, the tRNA (m7G46) methyltransferase. |
Nucleic Acids Res |
16600901 |
Songe-Moller L |
Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding. |
Mol Cell Biol |
20123966 |
Huang B |
An early step in wobble uridine tRNA modification requires the Elongator complex. |
RNA |
15769872 |
Yamada-Okabe T |
Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme. |
Nucleic Acids Res |
9512541 |
Tsukamoto T |
Cloning and characterization of two human cDNAs encoding the mRNA capping enzyme. |
Biochem Biophys Res Commun |
9473487 |
Pillutla RC |
Recombinant human mRNA cap methyltransferase binds capping enzyme/RNA polymerase IIo complexes. |
J Biol Chem |
9705270 |
Chu C |
Structure of the guanylyltransferase domain of human mRNA capping enzyme. |
Proc Natl Acad Sci U S A |
21636784 |
Tsukamoto T |
Cloning and characterization of three human cDNAs encoding mRNA (guanine-7-)-methyltransferase, an mRNA cap methylase. |
Biochem Biophys Res Commun |
9790902 |
Saha N |
Characterization of human, Schizosaccharomyces pombe, and Candida albicans mRNA cap methyltransferases and complete replacement of the yeast capping apparatus by mammalian enzymes. |
J Biol Chem |
10347220 |
Wen Y |
Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-alpha. |
Genes Dev |
11114884 |
Shafer B |
Human mRNA cap methyltransferase: alternative nuclear localization signal motifs ensure nuclear localization required for viability. |
Mol Cell Biol |
15767670 |
Gonatopoulos-Pournatzis T |
RAM/Fam103a1 is required for mRNA cap methylation. |
Mol Cell |
22099306 |
Hausmann S |
Genetic and biochemical analysis of yeast and human cap trimethylguanosine synthase: functional overlap of 2,2,7-trimethylguanosine caps, small nuclear ribonucleoprotein components, pre-mRNA splicing factors, and RNA decay pathways. |
J Biol Chem |
18775984 |
Monecke T |
Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1. |
Acta Crystallogr D Biol Crystallogr |
19307714 |
Belanger F |
Characterization of hMTr1, a human Cap1 2'-O-ribose methyltransferase. |
J Biol Chem |
20713356 |
Haline-Vaz T |
The human interferon-regulated ISG95 protein interacts with RNA polymerase II and shows methyltransferase activity. |
Biochem Biophys Res Commun |
18533109 |
Monecke T |
Structural basis for m7G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1. |
Nucleic Acids Res |
19386620 |
Werner M |
2'-O-ribose methylation of cap2 in human: function and evolution in a horizontally mobile family. |
Nucleic Acids Res |
21310715 |
Jeronimo C |
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme. |
Mol Cell |
17643375 |
Xue Y |
A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP. |
Nucleic Acids Res |
19906723 |
Gu M |
Insights into the structure, mechanism, and regulation of scavenger mRNA decapping activity. |
Mol Cell |
15068804 |
Liu H |
The scavenger mRNA decapping enzyme DcpS is a member of the HIT family of pyrophosphatases. |
EMBO J |
12198172 |
Kwasnicka DA |
Coordinate expression of NADPH-dependent flavin reductase, Fre-1, and Hint-related 7meGMP-directed hydrolase, DCS-1. |
J Biol Chem |
12871939 |
Wang Z |
Functional link between the mammalian exosome and mRNA decapping. |
Cell |
11747811 |
van Dijk E |
DcpS can act in the 5'-3' mRNA decay pathway in addition to the 3'-5' pathway. |
Proc Natl Acad Sci U S A |
14523240 |
Liu SW |
Functional analysis of mRNA scavenger decapping enzymes. |
RNA |
15273322 |
Treede I |
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. |
Mol Microbiol |
12828631 |
Mosbacher TG |
Crystal structure of the avilamycin resistance-conferring methyltransferase AviRa from Streptomyces viridochromogenes. |
J Mol Biol |
12742024 |
Weitnauer G |
An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tu57. |
Antimicrob Agents Chemother |
11181344 |
Mosbacher TG |
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. |
J Mol Biol |
15581897 |
Monod M |
Sequence and properties of pIM13, a macrolide-lincosamide-streptogramin B resistance plasmid from Bacillus subtilis. |
J Bacteriol |
3087948 |
Zhong P |
Substrate requirements for ErmC' methyltransferase activity. |
J Bacteriol |
7543473 |
Gath A |
Family background of children with Down's syndrome and of children with a similar degree of mental retardation. |
Br J Psychiatry |
2946350 |
Maravic G |
Alanine-scanning mutagenesis of the predicted rRNA-binding domain of ErmC' redefines the substrate-binding site and suggests a model for protein-RNA interactions. |
Nucleic Acids Res |
12907737 |
Bussiere DE |
Crystal structure of ErmC', an rRNA methyltransferase which mediates antibiotic resistance in bacteria. |
Biochemistry |
9585521 |
Schluckebier G |
The 2.2 A structure of the rRNA methyltransferase ErmC' and its complexes with cofactor and cofactor analogs: implications for the reaction mechanism. |
J Mol Biol |
10366505 |
Trieu-Cuot P |
Nucleotide sequence of the erythromycin resistance gene of the conjugative transposon Tn1545. |
Nucleic Acids Res |
2163525 |
Yu L |
Solution structure of an rRNA methyltransferase (ErmAM) that confers macrolide-lincosamide-streptogramin antibiotic resistance. |
Nat Struct Biol |
9187657 |
Bercot B |
Plasmid-mediated 16S rRNA methylases among extended-spectrum beta-lactamase-producing Enterobacteriaceae isolates. |
Antimicrob Agents Chemother |
18838598 |
Bibb MJ |
Nucleotide sequences encoding and promoting expression of three antibiotic resistance genes indigenous to Streptomyces. |
Mol Gen Genet |
2987648 |
Dunstan MS |
Structure of the thiostrepton resistance methyltransferase.S-adenosyl-L-methionine complex and its interaction with ribosomal RNA. |
J Biol Chem |
19369248 |
Bechthold A |
Overexpression of the thiostrepton-resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphatase center of 23S ribosomal RNA. |
Eur J Biochem |
7925357 |
Husain N |
Structural basis for the methylation of G1405 in 16S rRNA by aminoglycoside resistance methyltransferase Sgm from an antibiotic producer: a diversity of active sites in m7G methyltransferases. |
Nucleic Acids Res |
20194115 |
Kojic M |
Cloning and characterization of an aminoglycoside resistance determinant from Micromonospora zionensis. |
J Bacteriol |
1447159 |
Savic M |
Critical residues for cofactor binding and catalytic activity in the aminoglycoside resistance methyltransferase Sgm. |
J Bacteriol |
18586937 |
Yang H |
Crystallization and preliminary crystallographic analysis of nosiheptide-resistance methyltransferase from Streptomyces actuosus in complex with SAM. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
20445264 |
Goto-Ito S |
Crystal structure of archaeal tRNA(m(1)G37)methyltransferase aTrm5. |
Proteins |
18384044 |
Pitsch S. |
Reliable Chemical Synthesis of Oligoribonucleotides (RNA) with 2′-O-[(Triisopropylsilyl)oxy]methyl(2′-O-tom)-Protected Phosphoramidites |
Helvetica Chimica Acta |
10.1002/1522-2675(20011219)84:12<3773::AID-HLCA377 |
Chaix C. |
The use of labilebaseprotectinggroups in oligoribonucleotidesynthesis |
Tetrahedron Letters |
10.1016/S0040-4039(01)80326-9 |
Reddy M.P. |
Methylaminedeprotectionprovidesincreasedyield of oligoribonucleotides |
Tetrahedron Letters |
10.1016/0040-4039(95)01953-F |
Bogdan F. M. |
The Synthesis of Allyl- and Ailyioxycarbonyl-Protected RNA Phosphoramidites. Useful Reagents for Solid-Phase Synthesis of RNAs with Base-Labile Modifications |
Tetrahedron Letters |
10.1016/S0040-4039(98)00157-9 |
Karpeisky A. |
2′-O-Methyl Thiomethyl Modifications in Hammerhead Ribozymes |
Nucleosides and Nucleotides |
10.1080/07328319708006114 |
Reddy M.P. |
Ultrafast Cleavage and Deprotection of Oligonucleotides Synthesis and Use of CAc Derivatives |
Nucleosides and Nucleotides |
10.1080/07328319708006236 |
Martin P. |
Ein neuer Zugang zu 2’-O-Alkylribonucleosiden und Eigenschaften deren Oligonucleotide |
Helvetica Chimica Acta |
10.1002/hlca.19950780219 |
Bhattacharya B. K. |
A Facile Synthesis of the Phosphoramidites of 2-N-Methyl-2′- deoxy (or 2′-O-allyl)-ψ-isocytidine, 1, 3-Dimethyl-2′-deoxy-ψ-uridine and N1- Methyl-2′-O-allyl-ψ-uridine as Synthons Suitable for Oligonuc |
Nucleosides and Nucleotides |
10.1080/15257779408009476 |
Ohgi T |
A new RNA synthetic method with a 2'-O-(2-cyanoethoxymethyl) protecting group. |
Org Lett |
16048321 |
Hyde RM |
Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies. |
J Med Chem |
12723951 |
Shohda K |
Synthesis and properties of 2'-O-methyl-2-thiouridine and oligoribonucleotides containing 2'-O-methyl-2-thiouridine. |
Bioorg Med Chem Lett |
10969970 |
Porcher S. |
Synthesis of modified nucleosides for the incorporation into tRNAs |
|
|
Porcher S. |
Chemical Approach for the Study of the ‘Kissing Complex’ of Moloney murine leukaemia Virus |
Helvetica Chimica Acta |
10.1002/hlca.200890133 |
Atta M |
The methylthiolation reaction mediated by the Radical-SAM enzymes. |
Biochim Biophys Acta |
22178611 |
Takeda H |
Identification of Aquifex aeolicus tRNA (m2(2G26) methyltransferase gene. |
Nucleic Acids Res Suppl. |
12903189 |
Mitsui T |
Fluorescent properties of an unnatural nucleobase, 2-amino-6-(2-thienyl)purine, in DNA and RNA fragments. |
Nucleic Acids Symp Ser (Oxf) |
17150745 |
Awai T |
Aquifex aeolicus Trm1[tRNA (m2(2)G26) methyltransferase] has a novel recognition mechanism of the substrate RNA. |
Nucleic Acids Symp Ser (Oxf) |
17150754 |
Motorin Y |
RNA nucleotide methylation. |
Wiley Interdiscip Rev RNA |
21823225 |
McDonald MK |
The Handling of the Mechanistic Probe 5-Fluorouridine by the Pseudouridine Synthase TruA and Its Consistency with the Handling of the Same Probe by the Pseudouridine Synthases TruB and RluA. |
Biochemistry |
21142053 |
O'Farrell HC |
Crystal structure of KsgA, a universally conserved rRNA adenine dimethyltransferase in Escherichia coli. |
J Mol Biol |
15136037 |
Chikwana VM |
Structural Basis of Biological Nitrile Reduction. |
J Biol Chem |
22787148 |
Duan J |
Structural mechanism of substrate RNA recruitment in H/ACA RNA-guided pseudouridine synthase. |
Mol Cell |
19481523 |
Kagawa N |
cAMP-dependent transcription of the human CYP21B (P-450C21) gene requires a cis-regulatory element distinct from the consensus cAMP-regulatory element. |
J Biol Chem |
2162843 |
Muller S |
Identification of determinants in the protein partners aCBF5 and aNOP10 necessary for the tRNA:Psi55-synthase and RNA-guided RNA:Psi-synthase activities. |
Nucleic Acids Res |
17704128 |
Gurha P |
Differential roles of archaeal box H/ACA proteins in guide RNA-dependent and independent pseudouridine formation. |
RNA Biol |
17993784 |
Blaby IK |
Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii. |
RNA |
21628430 |
Torabi N |
Variants in SUP45 and TRM10 underlie natural variation in translation termination efficiency in Saccharomyces cerevisiae. |
PLoS Genet |
21829385 |
Noma A |
Expanding role of the jumonji C domain as an RNA hydroxylase. |
J Biol Chem |
20739293 |
Kato M |
Crystal structure of a novel JmjC-domain-containing protein, TYW5, involved in tRNA modification. |
Nucleic Acids Res |
20972222 |
Walbott H |
The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic. |
Genes Dev |
22085966 |
Sakuno T |
Decapping reaction of mRNA requires Dcp1 in fission yeast: its characterization in different species from yeast to human. |
J Biochem |
15671491 |
Hausmann S |
An essential function of Saccharomyces cerevisiae RNA triphosphatase Cet1 is to stabilize RNA guanylyltransferase Ceg1 against thermal inactivation. |
J Biol Chem |
11463793 |
Kasprzak JM |
Molecular evolution of dihydrouridine synthases. |
BMC Bioinformatics |
22741570 |
Rider LW |
Mechanism of dihydrouridine synthase 2 from yeast and the importance of modifications for efficient tRNA reduction. |
J Biol Chem |
19139092 |
Chen C |
Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. |
PLoS Genet |
21912530 |
Otero G |
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. |
Mol Cell |
10024884 |
Galimand M |
Intrinsic resistance to aminoglycosides in Enterococcus faecium is conferred by the 16S rRNA m5C1404-specific methyltransferase EfmM. |
RNA |
21159796 |
Rottman FM |
N6-adenosine methylation in mRNA: substrate specificity and enzyme complexity. |
Biochimie |
7748945 |
Leach RA |
Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells. |
Int J Biochem Cell Biol |
11470232 |
Bokar JA |
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. |
RNA |
9409616 |
Maas S |
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes. |
Proc Natl Acad Sci U S A |
10430867 |
Liu J |
The human tRNA(m(2)(2)G(26))dimethyltransferase: functional expression and characterization of a cloned hTRM1 gene. |
Nucleic Acids Res |
10982862 |
Brzezicha B |
Identification of human tRNA:m5C methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA). |
Nucleic Acids Res |
17071714 |
Squires JE |
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA. |
Nucleic Acids Res |
22344696 |
Squires JE |
Function and detection of 5-methylcytosine in eukaryotic RNA. |
Epigenomics |
22122054 |
Goll MG |
Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2. |
Science |
16424344 |
Dong A |
Structure of human DNMT2, an enigmatic DNA methyltransferase homolog that displays denaturant-resistant binding to DNA. |
Nucleic Acids Res |
11139614 |
Benitez-Paez A |
The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy. |
RNA |
22891362 |
Yanagawa H |
A novel minimum ribozyme with oxidoreduction activity. |
Biochemistry |
2271669 |
Kupfer PA |
Synthesis, base pairing properties and trans-lesion synthesis by reverse transcriptases of oligoribonucleotides containing the oxidatively damaged base 5-hydroxycytidine. |
Nucleic Acids Res |
21852326 |
Dumelin CE |
Discovery and biological characterization of geranylated RNA in bacteria. |
Nat Chem Biol |
22983156 |
Chen P |
A gain of function mutation in a protein mediates production of novel modified nucleosides. |
EMBO J |
15861125 |
Kim IY |
Escherichia coli mutant SELD enzymes. The cysteine 17 residue is essential for selenophosphate formation from ATP and selenide. |
J Biol Chem |
1527085 |
Veres Z |
Selenophosphate synthetase. Enzyme properties and catalytic reaction. |
J Biol Chem |
8144648 |
Lacourciere GM |
Biosynthesis of selenophosphate. |
Biofactors |
10609888 |
Li X |
A human mitochondrial GTP binding protein related to tRNA modification may modulate phenotypic expression of the deafness-associated mitochondrial 12S rRNA mutation. |
Mol Cell Biol |
12370316 |
Kitamura A |
Characterization and structure of the Aquifex aeolicus protein DUF752: a bacterial tRNA-methyltransferase (MnmC2) functioning without the usually fused oxidase domain (MnmC1). |
J Biol Chem |
23091054 |
McCusker KP |
Covalent Intermediate in the Catalytic Mechanism of the Radical S-Adenosyl-l-methionine Methyl Synthase RlmN Trapped by Mutagenesis. |
J Am Chem Soc |
23088750 |
Auxilien S |
The Human tRNA m ( 5) C methyltransferase Misu is multisite-specific. |
RNA Biol |
22995836 |
Xhemalce B |
Human RNA Methyltransferase BCDIN3D Regulates MicroRNA Processing. |
Cell |
23063121 |
Hamdane D |
FAD/Folate-Dependent tRNA Methyltransferase: Flavin as a new methyl-transfer agent. |
J Am Chem Soc |
23157377 |
Bousquet-Antonelli C |
Rrp8p is a yeast nucleolar protein functionally linked to Gar1p and involved in pre-rRNA cleavage at site A2. |
RNA |
10864042 |
Leulliot N |
The box H/ACA RNP assembly factor Naf1p contains a domain homologous to Gar1p mediating its interaction with Cbf5p. |
J Mol Biol |
17612558 |
Agarwala SD |
RNA methylation by the MIS complex regulates a cell fate decision in yeast. |
PLoS Genet |
22685417 |
Ollagnier-de-Choudens S |
SufA/IscA: reactivity studies of a class of scaffold proteins involved in [Fe-S] cluster assembly. |
J Biol Inorg Chem |
15278785 |
Lundgren HK |
Structural alterations of the cysteine desulfurase IscS of Salmonella enterica serovar Typhimurium reveal substrate specificity of IscS in tRNA thiolation. |
J Bacteriol |
16585765 |
Saito H |
Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2. |
Cytogenet Cell Genet |
8978773 |
Kiss T |
Biogenesis and intranuclear trafficking of human box C/D and H/ACA RNPs. |
Cold Spring Harb Symp Quant Biol |
17381323 |
Muhlenhoff U |
Functional characterization of the eukaryotic cysteine desulfurase Nfs1p from Saccharomyces cerevisiae. |
J Biol Chem |
15220327 |
Pandey A |
Isd11p protein activates the mitochondrial cysteine desulfurase Nfs1p protein. |
J Biol Chem |
21908622 |
Koo BK |
Structure of H/ACA RNP protein Nhp2p reveals cis/trans isomerization of a conserved proline at the RNA and Nop10 binding interface. |
J Mol Biol |
21708174 |
Peifer C |
Yeast Rrp8p, a novel methyltransferase responsible for m1A 645 base modification of 25S rRNA. |
Nucleic Acids Res |
23180764 |
Yamagami R |
The tRNA recognition mechanism of folate/FAD-dependent tRNA methyltransferase (TrmFO). |
J Biol Chem |
23095745 |
Guy MP |
Yeast Trm7 interacts with distinct proteins for critical modifications of the tRNAPhe anticodon loop. |
RNA |
22912484 |
Zheng G |
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. |
Mol Cell |
23177736 |
Thalhammer A |
Human AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1alpha (HIF-1alpha). |
PLoS One |
21264265 |
Tkaczuk KL |
Trm13p, the tRNA:Xm4 modification enzyme from Saccharomyces cerevisiae is a member of the Rossmann-fold MTase superfamily: prediction of structure and active site. |
J Mol Model |
19697067 |
Sorensen MA |
Over expression of a tRNA(Leu) isoacceptor changes charging pattern of leucine tRNAs and reveals new codon reading. |
J Mol Biol |
16236318 |
Griffey RH |
15N-labeled tRNA. Identification of 4-thiouridine in Escherichia coli tRNASer1 and tRNATyr2 by 1H-15N two-dimensional NMR spectroscopy. |
J Biol Chem |
3638307 |
Fislage M |
Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. |
Nucleic Acids Res |
22362751 |
Schweizer MP |
The isolation and characterization of N-[9-(beta-D-ribofuranosyl)-purin-6-ylcarbamoyl]glycine from yeast transfer RNA. |
Biochem Biophys Res Commun |
5503779 |
Patton JR |
Pseudouridine modification in Caenorhabditis elegans spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions. |
BMC Mol Biol |
16236171 |
Meier UT |
Pseudouridylation goes regulatory. |
EMBO J |
21206510 |
Wu G |
U2 snRNA is inducibly pseudouridylated at novel sites by Pus7p and snR81 RNP. |
EMBO J |
21131909 |
Patton JR |
Caenorhabditis elegans pseudouridine synthase 1 activity in vivo: tRNA is a substrate, but not U2 small nuclear RNA. |
Biochem J |
12597772 |
Chujo T |
Trmt61B is a methyltransferase responsible for 1-methyladenosine at position 58 of human mitochondrial tRNAs. |
RNA |
23097428 |
Miyauchi K |
A cyclic form of N(6)-threonylcarbamoyladenosine as a widely distributed tRNA hypermodification. |
Nat Chem Biol |
23242255 |
Vilardo E |
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. |
Nucleic Acids Res |
23042678 |
Ishida K |
Pseudouridine at position 55 in tRNA controls the contents of other modified nucleotides for low-temperature adaptation in the extreme-thermophilic eubacterium Thermus thermophilus. |
Nucleic Acids Res |
21097467 |
Larsen LH |
Identification and characterization of the Thermus thermophilus 5-methylcytidine (m5C) methyltransferase modifying 23 S ribosomal RNA (rRNA) base C1942. |
J Biol Chem |
22711535 |
Savic M |
Determination of the target nucleosides for members of two families of 16S rRNA methyltransferases that confer resistance to partially overlapping groups of aminoglycoside antibiotics. |
Nucleic Acids Res |
19589804 |
Pioszak AA |
Structures of a putative RNA 5-methyluridine methyltransferase, Thermus thermophilus TTHA1280, and its complex with S-adenosyl-L-homocysteine. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
16511182 |
Shisler KA |
Emerging themes in radical SAM chemistry. |
Curr Opin Struct Biol |
23141873 |
Golovina AY |
The last rRNA methyltransferase of E. coli revealed: the yhiR gene encodes adenine-N6 methyltransferase specific for modification of A2030 of 23S ribosomal RNA. |
RNA |
22847818 |
Matsugi J |
Characterization of a B. subtilis minor isoleucine tRNA deduced from tDNA having a methionine anticodon CAT. |
J Biochem |
8743586 |
Yamazaki S |
Characterization of a whole set of tRNA molecules in an aerobic hyper-thermophilic Crenarchaeon, Aeropyrum pernix K1. |
DNA Res |
16769697 |
Randau L |
The complete set of tRNA species in Nanoarchaeum equitans. |
FEBS Lett |
15893316 |
Wang C |
Loss of a universal tRNA feature. |
J Bacteriol |
17172343 |
Esseiva AC |
Mitochondrial tRNA import in Toxoplasma gondii. |
J Biol Chem |
15280394 |
Sunny Sharma |
Identification of a novel methyltransferase, Bmt2, responsible for the N-1-methyl-adenosine base modification of 25S rRNA in Saccharomyces cerevisiae |
Nucleic Acids Res |
23558746 |
Plotnikova A |
Mechanistic insights into small RNA recognition and modification by the HEN1 methyltransferase. |
Biochem J |
23621770 |
Fu Y |
FTO-mediated formation of N(6)-hydroxymethyladenosine and N(6)-formyladenosine in mammalian RNA. |
Nat Commun |
23653210 |
Jia G |
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. |
Nat Chem Biol |
22002720 |
Han Z |
Crystal structure of the FTO protein reveals basis for its substrate specificity. |
Nature |
20376003 |
Kim J |
Structure-guided discovery of the metabolite carboxy-SAM that modulates tRNA function. |
Nature |
23676670 |
Byrne RT |
S-Adenosyl-S-carboxymethyl-L-homocysteine: a novel cofactor found in the putative tRNA-modifying enzyme CmoA. |
Acta Crystallogr D Biol Crystallogr |
23695253 |
Voorhees RM |
The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome. |
Nat Struct Mol Biol |
23542153 |
Kamalampeta R |
tRNA binding, positioning and modification by the pseudouridine synthase Pus10. |
J Mol Biol |
23743107 |
Liu RJ |
The tRNA recognition mechanism of the minimalist SPOUT methyltransferase, TrmL. |
Nucleic Acids Res |
23804755 |
Swinehart WE |
Unexpected expansion of tRNA substrate recognition by the yeast m1G9 methyltransferase Trm10. |
RNA |
23793893 |
Christian T |
Conservation of structure and mechanism by Trm5 enzymes. |
RNA |
23887145 |
Hori H |
Identification and characterization of tRNA (Gm18) methyltransferase from Thermus thermophilus HB8: domain structure and conserved amino acid sequence motifs. |
Genes Cells |
11918670 |
Hori H |
Substrate recognition of tRNA (Guanosine-2'-)-methyltransferase from Thermus thermophilus HB27. |
J Biol Chem |
9748240 |
Nureki O |
Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme. |
Structure |
15062082 |
Ochi A |
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and non-substrate tRNA via an induced-fit process. |
J Biol Chem |
23867454 |
Chen M |
Structure of dihydrouridine synthase C (DusC) from Escherichia coli. |
Acta Crystallogr Sect F Struct Biol Cryst Commun |
23908023 |
Sharma S |
Yeast Nop2 and Rcm1 methylate C2870 and C2278 of the 25S rRNA, respectively. |
Nucleic Acids Res |
23913415 |
Sardana R |
The methyltransferase adaptor protein Trm112 is involved in biogenesis of both ribosomal subunits. |
Mol Biol Cell |
22956767 |
Punekar AS |
Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ. |
Nucleic Acids Res |
23945937 |
Noon KR |
Influence of temperature on tRNA modification in archaea: Methanococcoides burtonii (optimum growth temperature [Topt], 23 degrees C) and Stetteria hydrogenophila (Topt, 95 degrees C). |
J Bacteriol |
12949100 |
Shao Z |
Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate |
Nucleic Acids Res. |
24081582 |
Rodriguez V |
Structure-function analysis of human TYW2 enzyme required for the biosynthesis of a highly modified Wybutosine (yW) base in phenylalanine-tRNA. |
PLoS One |
22761755 |
Ghosh SK |
A small RNA derived from RNA coactivator SRA blocks steroid receptor signaling via inhibition of Pus1p-mediated pseudouridylation of SRA: evidence of a novel RNA binding domain in the N-terminus of steroid receptors. |
Biochemistry |
22998747 |
Sibert BS |
Pseudouridine synthase 1: a site-specific synthase without strict sequence recognition requirements. |
Nucleic Acids Res |
22102571 |
Sibert BS |
Partial activity is seen with many substitutions of highly conserved active site residues in human Pseudouridine synthase 1. |
RNA |
18648068 |
Patton JR |
Mitochondrial myopathy and sideroblastic anemia (MLASA): missense mutation in the pseudouridine synthase 1 (PUS1) gene is associated with the loss of tRNA pseudouridylation. |
J Biol Chem |
15772074 |
Czudnochowski N |
In Human Pseudouridine Synthase 1 (hPus1), a C-Terminal Helical Insert Blocks tRNA from Binding in the Same Orientation as in the Pus1 Bacterial Homologue TruA, Consistent with Their Different Target Selectivities. |
J Mol Biol |
23707380 |
Helm M |
The presence of modified nucleotides is required for cloverleaf folding of a human mitochondrial tRNA. |
Nucleic Acids Res |
9512533 |
Suzuki T |
Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases. |
EMBO J |
12456664 |
Yasukawa T |
Wobble modification deficiency in mutant tRNAs in patients with mitochondrial diseases. |
FEBS Lett |
15893315 |
Brule H |
Effect of a mutation in the anticodon of human mitochondrial tRNAPro on its post-transcriptional modification pattern. |
Nucleic Acids Res |
9421512 |
Messmer M |
Tertiary network in mammalian mitochondrial tRNAAsp revealed by solution probing and phylogeny. |
Nucleic Acids Res |
19767615 |
Kirino Y |
Acquisition of the wobble modification in mitochondrial tRNALeu(CUN) bearing the G12300A mutation suppresses the MELAS molecular defect. |
Hum Mol Genet |
16446307 |
Jones CN |
A disease-causing point mutation in human mitochondrial tRNAMet rsults in tRNA misfolding leading to defects in translational initiation and elongation. |
J Biol Chem |
18835817 |
Kim J |
Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. |
BMC Struct Biol |
23617613 |
Chan CT |
Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. |
Nat Commun |
22760636 |
Liu J |
A METTL3-METTL14 complex mediates mammalian nuclear RNA N-adenosine methylation. |
Nat Chem Biol |
24316715 |
Mandal D |
Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. |
RNA |
24344322 |
Sharma S |
Identification of novel methyltransferases, Bmt5 and Bmt6, responsible for the m3U methylations of 25S rRNA in Saccharomyces cerevisiae. |
Nucleic Acids Res |
24335083 |
Friedt J |
An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation. |
Nucleic Acids Res |
24371284 |
Moukadiri I |
The output of the tRNA modification pathways controlled by the Escherichia coli MnmEG and MnmC enzymes depends on the growth conditions and the tRNA species. |
Nucleic Acids Res |
24293650 |
Aik W |
Structure of human RNA N6-methyladenine demethylase ALKBH5 provides insights into its mechanisms of nucleic acid recognition and demethylation. |
Nucleic Acids Res |
24489119 |
Buchhaupt M |
Partial Methylation at Am100 in 18S rRNA of Baker's Yeast Reveals Ribosome Heterogeneity on the Level of Eukaryotic rRNA Modification. |
PLoS One |
24586927 |
Feng C |
Crystal Structures of Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition. |
J Biol Chem |
24616105 |
Nilsen TW |
Molecular biology. Internal mRNA methylation finally finds functions. |
Science |
24626918 |
Fislage M |
SAXS analysis of the tRNA-modifying enzyme complex MnmE/MnmG reveals a novel interaction mode and GTP-induced oligomerization. |
Nucleic Acids Res |
24634441 |
Dunkle JA |
Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. |
Proc Natl Acad Sci U S A |
24717845 |
Kuchino Y |
Initiator tRNAs from archaebacteria show common unique sequence characteristics. |
Nature |
6178978 |
Liu N |
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA. |
RNA |
24141618 |
Xu C |
Structures of human ALKBH5 demethylase reveal a unique binding mode for specific single stranded m6A RNA demethylation. |
J Biol Chem |
24778178 |
Tomikawa C |
Distinct tRNA modifications in the thermo-acidophilic archaeon, Thermoplasma acidophilum. |
FEBS Lett |
24076028 |
Young AP |
Radical mediated ring formation in the biosynthesis of the hypermodified tRNA base wybutosine. |
Curr Opin Chem Biol |
23856057 |
Young AP |
Pyruvate is the source of the two carbons that are required for formation of the imidazoline ring of 4-demethylwyosine. |
Biochemistry |
22026549 |
Perche-Letuvee P |
4-Demethylwyosine synthase from Pyrococcus abyssi is a radical-S-adenosyl-L-methionine enzyme with an additional [4Fe-4S](+2) cluster that interacts with the pyruvate co-substrate. |
J Biol Chem |
23043105 |
Suzuki T |
A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs. |
Nucleic Acids Res |
24831542 |
Nagao A |
Biogenesis of glutaminyl-mt tRNAGln in human mitochondria. |
Proc Natl Acad Sci U S A |
19805282 |
Yokogawa T |
A novel cloverleaf structure found in mammalian mitochondrial tRNA(Ser) (UCN). |
Nucleic Acids Res |
1840673 |
Auxilien S |
Archease from Pyrococcus abyssi improves substrate specificity and solubility of a tRNA m5C methyltransferase. |
J Biol Chem |
17470432 |
Phillips G |
Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA. |
J Biol Chem |
20129918 |
Lauhon CT |
Mechanism of N6-threonylcarbamoyladenonsine (t(6)A) biosynthesis: isolation and characterization of the intermediate threonylcarbamoyl-AMP. |
Biochemistry |
23072323 |
Heyman T |
Yeast serine isoacceptor tRNAs: variations of their content as a function of growth conditions and primary structure of the minor tRNA(Ser)GCU. |
FEBS Lett |
8033992 |
Sauerwald A |
N6-Acetyladenosine: a new modified nucleoside from Methanopyrus kandleri tRNA. |
FEBS Lett |
15907485 |
Lartigue C |
The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA. |
Nucleic Acids Res |
24939895 |
Somme J |
Characterization of two homologous 2'-O-methyltransferases showing different specificities for their tRNA substrates. |
RNA |
24951554 |
Shanmugam R |
The Dnmt2 RNA methyltransferase homolog of Geobacter sulfurreducens specifically methylates tRNA-Glu. |
Nucleic Acids Res |
24711368 |
Bouvier D |
TtcA a new tRNA-thioltransferase with an Fe-S cluster. |
Nucleic Acids Res |
24914049 |
Gillis D |
TRMT10A dysfunction is associated with abnormalities in glucose homeostasis, short stature and microcephaly. |
J Med Genet |
25053765 |
Ito S |
A single acetylation of 18S rRNA is essential for biogenesis of the small ribosomal subunit in Saccharomyces cerevisiae. |
J Biol Chem |
25086048 |
Kuiper EG |
Binding Induced RNA Conformational Changes Control Substrate Recognition and Catalysis by the Thiostrepton-resistance Methyltransferase (Tsr). |
J Biol Chem |
25086036 |
Lee KW |
Assignment of 2'-O-methyltransferases to Modification Sites on the Mammalian Mitochondrial Large Subunit 16S rRNA. |
J Biol Chem |
25074936 |
Kimura S |
Discovery of the beta-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. |
Nucleic Acids Res |
25063302 |
Urbonavicius J |
Biosynthesis of wyosine derivatives in tRNA(Phe) of Archaea: role of a remarkable bifunctional tRNA(Phe):m1G/imG2 methyltransferase. |
RNA |
24837075 |
Gigova A |
A cluster of methylations in the domain IV of 25S rRNA is required for ribosome stability. |
RNA |
25125595 |
Moon HJ |
Trm4 and Nsun2 RNA:mC Methyltransferases Form Metabolite-Dependent, Covalent Adducts with Previously Methylated RNA. |
Biochemistry |
25375641 |
Yuan S |
Methylation by NSun2 represses the levels and function of microRNA 125b. |
Mol Cell Biol |
25047833 |
Tominaga T |
Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP. |
Acta Crystallogr F Struct Biol Commun |
25084372 |
Letoquart J |
Structural and functional studies of Bud23-Trm112 reveal 18S rRNA N7-G1575 methylation occurs on late 40S precursor ribosomes. |
Proc Natl Acad Sci U S A |
25489090 |
Wurth L |
Hypermethylated-capped selenoprotein mRNAs in mammals. |
Nucleic Acids Res |
25013170 |
Zhao X |
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. |
Cell Res |
25412662 |
Wei Y |
Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA. |
J Struct Biol |
22561317 |
Zhao M |
Purification, crystallization and preliminary crystallographic analysis of the 16S rRNA methyltransferase RsmI from Escherichia coli. |
Acta Crystallogr F Struct Biol Commun |
25195904 |
Hamdane D |
Dynamics of RNA modification by a multi-site-specific tRNA methyltransferase. |
Nucleic Acids Res |
25217588 |
Guelorget A |
Insights into the hyperthermostability and unusual region-specificity of archaeal Pyrococcus abyssi tRNA m1A57/58 methyltransferase. |
Nucleic Acids Res |
20483913 |
Ito S |
Human NAT10 is an ATP-dependent RNA acetyltransferase responsible for N4-acetylcytidine formation in 18S rRNA. |
J Biol Chem |
25411247 |
Taoka M |
RNA Cytidine Acetyltransferase of Small-Subunit Ribosomal RNA: Identification of Acetylation Sites and the Responsible Acetyltransferase in Fission Yeast, Schizosaccharomyces pombe. |
PLoS One |
25402480 |
Huet T |
Steroid receptor RNA activator (SRA) modification by the human pseudouridine synthase 1 (hPus1p): RNA binding, activity, and atomic model. |
PLoS One |
24722331 |
Glatt S |
Structure of the Kti11/Kti13 Heterodimer and Its Double Role in Modifications of tRNA and Eukaryotic Elongation Factor 2. |
Structure |
25543256 |
Sun J |
Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module. |
Biochemistry |
15952786 |
Reddy DM |
Structure determination of two new amino acid-containing derivatives of adenosine from tRNA of thermophilic bacteria and archaea. |
Nucleic Acids Res |
1280806 |
Schosserer M |
Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. |
Nat Commun |
25635753 |
Sharma S |
Yeast Kre33 and human NAT10 are conserved 18S rRNA cytosine acetyltransferases that modify tRNAs assisted by the adaptor Tan1/THUMPD1. |
Nucleic Acids Res |
25653167 |
Glasser AL |
Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast. |
FEBS Lett |
1468572 |
Guy MP |
Conservation of an intricate circuit for crucial modifications of the tRNAPhe anticodon loop in eukaryotes. |
RNA |
25404562 |
Szweykowska-Kulinska Z |
Intron-dependent formation of pseudouridines in the anticodon of Saccharomyces cerevisiae minor tRNA(Ile). |
EMBO J |
7925304 |
Kim J |
Determinants of the CmoB carboxymethyl transferase utilized for selective tRNA wobble modification. |
Nucleic Acids Res |
25855808 |
Tyagi K |
Protein degradation and dynamic tRNA thiolation fine-tune translation at elevated temperatures. |
Nucleic Acids Res |
25870413 |
Johansson MJ |
Eukaryotic wobble uridine modifications promote a functionally redundant decoding system. |
Mol Cell Biol |
18332122 |
Wittwer AJ |
Selenium-containing tRNA(Glu) and tRNA(Lys) from Escherichia coli: purification, codon specificity and translational activity. |
Biofactors |
2679651 |
Kim S |
The Structure of Escherichia coli TcdA (Also Known As CsdL) Reveals a Novel Topology and Provides Insight into the tRNA Binding Surface Required for N-Threonylcarbamoyladenosine Dehydratase Activity. |
J Mol Biol |
26101842 |
Lopez-Estepa M |
The crystal structure and small-angle X-ray analysis of CsdL/TcdA reveal a new tRNA binding motif in the MoeB/E1 superfamily. |
PLoS One |
25897750 |
Bou-Nader C |
An extended dsRBD is required for post-transcriptional modification in human tRNAs. |
Nucleic Acids Res |
26429968 |
Shaheen R |
Mutation in WDR4 impairs tRNA m(7)G46 methylation and causes a distinct form of microcephalic primordial dwarfism. |
Genome Biol |
26416026 |
Finer-Moore J |
Crystal Structure of the Human tRNA mA58 Methyltransferase-tRNA Complex: Refolding of Substrate tRNA allows Access to the Methylation Target. |
J Mol Biol |
26470919 |
Letoquart J |
Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure. |
Nucleic Acids Res |
26438534 |
Militello KT |
A map of 5-methylcytosine residues in Trypanosoma brucei tRNA revealed by sodium bisulfite sequencing. |
Mol Biochem Parasitol |
24389163 |
Sakai Y |
Biogenesis and growth phase-dependent alteration of 5-methoxycarbonylmethoxyuridine in tRNA anticodons |
Nucleic Acids Res. |
26681692 |
Kawamura T |
Multisite-specific archaeosine tRNA-guanine transglycosylase (ArcTGT) from Thermoplasma acidophilum, a thermo-acidophilic archaeon. |
Nucleic Acids Res. |
26721388 |
Sitao Yin |
Substrate Recognition and Modification by the Nosiheptide Resistance Methyltransferase |
PLoS One. |
4409310 |
Takuma H |
Substrate tRNA recognition mechanism of eubacterial tRNA (m1A58) methyltransferase (TrmI). |
J Biol Chem. |
25593312 |
Patil A |
Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. |
RNA Biol. |
22832247 |
Lin CJ |
An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis |
RNA |
26516084 |
Müller M |
Dynamic modulation of Dnmt2-dependent tRNA methylation by the micronutrient queuine. |
Nucleic Acids Res. |
26424849 |
Ramírez V |
Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity. |
PLoS Genet. |
26492405 |
Kellner S |
Profiling of RNA modifications by multiplexed stable isotope labelling. |
Chem Commun (Camb). |
24567952 |
Su D |
Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. |
Nat Protoc |
24625781 |
Kellner S |
Absolute and relative quantification of RNA modifications via biosynthetic isotopomers. |
Nucleic Acids Res |
25129236 |
Pendleton KE |
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention |
Cell |
28525753 |
Haag S |
NSUN6 is a human RNA methyltransferase that catalyzes formation of m5C72 in specific tRNAs. |
RNA |
26160102 |
Long T |
Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6. |
J Biol Chem |
27703015 |
Liu RJ |
Structural basis for substrate binding and catalytic mechanism of a human RNA:m5C methyltransferase NSun6. |
Nucleic Acids Res |
28531330 |
Xu L |
Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. |
J Biol Chem |
28655767 |
Metodiev MD |
NSUN4 is a dual function mitochondrial protein required for both methylation of 12S rRNA and coordination of mitoribosomal assembly. |
PLoS Genet. |
24516400 |
Spåhr H |
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis. |
Proc Natl Acad Sci U S A |
22949673 |
Cámara Y |
MTERF4 regulates translation by targeting the methyltransferase NSUN4 to the mammalian mitochondrial ribosome. |
Cell Metab. |
21531335 |
McCulloch V |
A human mitochondrial transcription factor is related to RNA adenine methyltransferases and binds S-adenosylmethionine. |
Mol Cell Biol. |
11809803 |
Metodiev MD |
Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome. |
Cell Metab. |
19356719 |
Rorbach J |
MRM2 and MRM3 are involved in biogenesis of the large subunit of the mitochondrial ribosome. |
Mol Biol Cell |
25009282 |
Zaganelli S |
The Pseudouridine Synthase RPUSD4 Is an Essential Component of Mitochondrial RNA Granules. |
J Biol Chem |
28082677 |
Antonicka H |
A pseudouridine synthase module is essential for mitochondrial protein synthesis and cell viability. |
EMBO Rep. |
27974379 |
Nakano S, Suzuki T, Kawarada L, Iwata H, Asano K, |
NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNA(Met). |
Nat Chem Biol. |
27214402 |
Van Haute L |
Deficient methylation and formylation of mt-tRNA(Met) wobble cytosine in a patient carrying mutations in NSUN3. |
Nat Commun. |
27356879 |
Haag S |
NSUN3 and ABH1 modify the wobble position of mt-tRNAMet to expand codon recognition in mitochondrial translation. |
ENBO J. |
27497299 |
Chen YC |
Characterization of the human tRNA-guanine transglycosylase: confirmation of the heterodimeric subunit structure. |
RNS |
20354154 |
Shaheen R |
A homozygous truncating mutation in PUS3 expands the role of tRNA modification in normal cognition. |
Hum Genet. |
27055666 |
Mundus J |
Identification of the methyltransferase targeting C2499 in Deinococcus radiodurans 23S ribosomal RNA. |
Extremophiles |
26590840 |
Zhong S |
MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. |
Plant Cell |
18505803 |
Růžička K |
Identification of factors required for m(6) A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI. |
New Phytol. |
28503769 |
Guan-Zheng Luo |
Unique Features of the m6A Methylome in Arabidopsis thaliana |
Nat Commun. |
25430002 |
Byeong-il Kang |
Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAs |
Nucleic Acids Research |
5389704 |
Ntokou E |
Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases |
PLoS One |
26700482 |
Van Laer B |
Structural and functional insights into tRNA binding and adenosine N1-methylation by an archaeal Trm10 homologue. |
Nucleic Acids Res. |
26673726 |
Deng W |
Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation |
PLoS Genet. |
26670883 |
Shoji T |
RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithr |
Nucleic Acids Res |
26365244 |
Liu RJ |
tRNA recognition by a bacterial tRNA Xm32 modification enzyme from the SPOUT methyltransferase superfamily. |
Nucleic Acids Res. |
26202969 |
Zhou M |
Identification of determinants for tRNA substrate recognition by Escherichia coli C/U34 2'-O-methyltransferase. |
RNA Biol. |
26106808 |
Zorbas C |
The human 18S rRNA base methyltransferases DIMT1L and WBSCR22-TRMT112 but not rRNA modification are required for ribosome biogenesis. |
Mol Biol Cell |
25851604 |
Nagao A |
Hydroxylation of a conserved tRNA modification establishes non-universal genetic code in echinoderm mitochondria. |
Nat Struct Mol Biol |
28783151 |
Dal Magro C |
A vastly increased chemical variety of RNA modifications that includes a thioacetal structure |
Angew. Chem. Int. Ed. |
29624844 |
Kawarada L |
ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications. |
Nucleic Acids Res |
28472312 |
Hawkes NA |
Purification and characterization of the human elongator complex. |
J Biol Chem |
11714725 |
Schlieker CD |
A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. |
Proc Natl Acad Sci U S A |
19017811 |
Guzzi N |
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells. |
Cell |
29628141 |
Fleming IM |
A tRNA methyltransferase paralog is important for ribosome stability and cell division in Trypanosoma brucei. |
Sci Rep |
26888608 |
Schaub M |
RNA editing by adenosine deaminases generates RNA and protein diversity. |
Biochimie |
12457566 |
Ramser J |
A splice site mutation in the methyltransferase gene FTSJ1 in Xp11.23 is associated with non-syndromic mental retardation in a large Belgian family (MRX9). |
J Med Genet |
15342698 |
Freude K |
Mutations in the FTSJ1 gene coding for a novel S-adenosylmethionine-binding protein cause nonsyndromic X-linked mental retardation. |
Am J Hum Genet |
15162322 |
Xu J |
Solution structure of Urm1 and its implications for the origin of protein modifiers. |
Proc Natl Acad Sci U S A |
16864801 |
Matthies A |
Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry. |
Biochemistry |
15910006 |
Biederbick A |
Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. |
Mol Cell Biol |
16847322 |
Tong WH |
Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. |
EMBO J |
11060020 |
Wan LC |
Proteomic analysis of the human KEOPS complex identifies C14ORF142 as a core subunit homologous to yeast Gon7. |
Nucleic Acids Res |
27903914 |
Costessi A |
The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. |
PLoS One |
22912744 |
Edvardson S |
tRNA N6-adenosine threonylcarbamoyltransferase defect due to KAE1/TCS3 (OSGEP) mutation manifest by neurodegeneration and renal tubulopathy. |
Eur J Hum Genet |
28272532 |
Facchin S |
Functional homology between yeast piD261/Bud32 and human PRPK: both phosphorylate p53 and PRPK partially complements piD261/Bud32 deficiency. |
FEBS Lett |
12914926 |
Abe Y |
Cloning and characterization of a p53-related protein kinase expressed in interleukin-2-activated cytotoxic T-cells, epithelial tumor cell lines, and the testes. |
J Biol Chem |
11546806 |
Miyoshi A |
Identification of CGI-121, a novel PRPK (p53-related protein kinase)-binding protein. |
Biochem Biophys Res Commun |
12659830 |
Huber SM |
2'-O-Methyl-5-hydroxymethylcytidine: A Second Oxidative Derivative of 5-Methylcytidine in RNA. |
J Am Chem Soc |
28107630 |
Ryu H |
Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. |
Nucleic Acids Res |
29982645 |
Simonova A |
LC/MS analysis and deep sequencing reveal the accurate RNA composition in the HIV-1 virion. |
Sci Rep |
31213632 |
A Beghini |
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia. |
Hum Mol Genet |
11001933 |
Pauli C |
Site-specific methylation of 18S ribosomal RNA by SNORD42A is required for acutemyeloid leukemia cell proliferation. |
Blood |
32097467 |
Gillian I Rice |
Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature. |
Nat Genet |
23001123 |
Daniele Hasler |
The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness. |
Mol Cell |
32017898 |
Li H |
FTO is involved in Alzheimer's disease by targeting TSC1-mTOR-Tau signaling. |
Biochem Biophys Res Commun |
29501742 |
Keller L |
The obesity related gene, FTO, interacts with APOE, and is associated withAlzheimer's disease risk: a prospective cohort study. |
J Alzheimers Dis |
21098976 |
Reitz C |
Genetic variants in the Fat and Obesity Associated (FTO) gene and risk ofAlzheimer's disease. |
Arch Biochem Biophys |
23251365 |
Min Han |
Abnormality of m6A mRNA Methylation Is Involved in Alzheimer's Disease. |
Front Neurosci |
32184705 |
Maas S |
Underediting of glutamate receptor GluR-B mRNA in malignant gliomas. |
Proc Natl Acad Sci U S A |
11717408 |
Donnelly CJ |
Aberrant RNA homeostasis in amyotrophic lateral sclerosis: potential for newtherapeutic targets? |
Arch Biochem Biophys |
25531686 |
Zia Choudhry |
Association between obesity-related gene FTO and ADHD. |
Obesity (Silver Spring) |
23512716 |
Bhalla T |
Control of human potassium channel inactivation by editing of a small mRNA hairpin. |
Nat Struct Mol Biol |
15361858 |
Jie Han |
METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner. |
Mol Cancer |
31228940 |
Maosheng Cheng |
The mA methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling network. |
Oncogene |
30659266 |
Fan Yang |
Dynamic mA mRNA methylation reveals the role of METTL3-mA-CDCP1 signaling axis in chemical carcinogenesis. |
Oncogene |
30796352 |
Chaohui Gu |
Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N-methyladenosine of Notch1. |
Mol Cancer |
31760940 |
Lin-Jian Wang |
Wilms' tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation. |
J Cell Mol Med |
32281240 |
Ho AJ |
A commonly carried allele of the obesity-related FTO gene is associated with reducedbrain volume in the healthy elderly. |
Proc Natl Acad Sci USA |
20404173 |
Zhen Wei |
Topological Characterization of Human and Mouse mC Epitranscriptome Revealed by Bisulfite Sequencing. |
Int J Genomics |
30009162 |
Debora Fumagalli |
Principles Governing A-to-I RNA Editing in the Breast Cancer Transcriptome. |
Cell Rep |
26440892 |
Marcel V |
p53 acts as a safeguard of translational control by regulating fibrillarin and rRNAmethylation in cancer. |
Cancer Cell |
24029231 |
Cai X |
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancervia inhibiting tumor suppressor let-7g. |
Cancer Lett |
29174803 |
Nate J Fry |
N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progression. |
Oncotarget |
30131850 |
Chuanzhao Zhang |
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA. |
Proc Natl Acad Sci U S A |
27001847 |
Lianpin Wu |
Changes of N6-methyladenosine modulators promote breast cancer progression. |
BMC Cancer |
30953473 |
Yi Niu |
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. |
Mol Cancer |
30922314 |
Carolyn M Klinge |
HNRNPA2/B1 is upregulated in endocrine-resistant LCC9 breast cancer cells and alters the miRNA transcriptome when overexpressed in MCF-7 cells. |
Sci Rep |
31263129 |
Liwen Liu |
N6-methyladenosine-related Genomic Targets are Altered in Breast Cancer Tissue and Associated with Poor Survival. |
J Cancer |
31632489 |
Wang H |
N6-methyladenosine METTL3 promotes the breast cancer progression via targetingBcl-2. |
Gene |
31454538 |
Chen Z |
Transfer RNA demethylase ALKBH3 promotes cancer progression via induction oftRNA-derived small RNAs. |
Nucleic Acids Res |
30541109 |
Jain M |
RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure |
EMBO J |
30087110 |
Håkansson KEJ |
Genetic associations and regulation of expression indicate an independent role for14q32 snoRNAs in human cardiovascular disease. |
Cardiovasc Res |
30544252 |
Shun Zhou |
FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation. |
Mol Carcinog |
29315835 |
Dongling Zou |
The mA eraser FTO facilitates proliferation and migration of human cervical cancer cells. |
Cancer Cell Int |
31827395 |
Xiuli Wang |
Reduced mA mRNA methylation is correlated with the progression of human cervical cancer. |
Oncotarget |
29228737 |
Chen W |
A-to-I RNA editing of BLCAP lost the inhibition to STAT3 activation in cervicalcancer. |
Oncotarget |
28455960 |
Qingfei Jiang |
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia. |
Proc Natl Acad Sci U S A |
23275297 |
Ru Deng |
mA methyltransferase METTL3 suppresses colorectal cancer proliferation and migration through p38/ERK pathways. |
Onco Targets Ther |
31239708 |
Chen X |
METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-DependentPrimary miR-375 Processing. |
Mol Ther |
31839484 |
Ting Li |
METTL3 facilitates tumor progression via an mA-IGF2BP2-dependent mechanism in colorectal carcinoma. |
Mol Cancer |
31230592 |
Yujiro Nishizawa |
Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
Oncotarget |
29484125 |
Yang Bai |
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma. |
Front Oncol |
31131257 |
Yingmin Wu |
mA-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1. |
Mol Cancer |
30979372 |
Wen Peng |
Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway. |
J Exp Clin Cancer Res |
31492150 |
Tanabe A |
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiencyby which HIF-1α mRNA is translated. |
Cancer Lett |
26996300 |
Sae-Won Han |
RNA editing in RHOQ promotes invasion potential in colorectal cancer. |
J Exp Med |
24663214 |
Maik Grohmann |
Alternative splicing and extensive RNA editing of human TPH2 transcripts. |
PLoS One |
20126463 |
Chen SH |
RNA editing of apolipoprotein B mRNA. Sequence specificity determined by in vitrocoupled transcription editing. |
J Biol Chem |
2324099 |
Fernando Jose Martinez |
Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome. |
J Med Genet |
22577224 |
Daphna Nachmani |
Germline NPM1 mutations lead to altered rRNA 2'-O-methylation and cause dyskeratosis congenita. |
Nat Genet |
31570891 |
Jun Liu |
mA mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. |
Nat Cell Biol |
30154548 |
Li Fu |
RNA editing of drives early tumor invasion and metastasis in familial esophageal cancer. |
Proc Natl Acad Sci U S A |
28533408 |
Tim Hon Man Chan |
A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma. |
Gut |
23766440 |
Yuan-Bin Chen |
ADAR2 functions as a tumor suppressor via editing IGFBP7 in esophageal squamous cell carcinoma. |
Int J Oncol |
28035363 |
Li Y |
Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF inesophageal squamous cell carcinoma. |
Cancer Lett |
29763634 |
Jun Zhang |
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1. |
J Physiol Biochem |
31290116 |
Sen Lin |
METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells. |
Open Med (Wars) |
30886897 |
Tong Liu |
Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. |
J Cell Physiol |
31232471 |
Dong Xu |
FTO expression is associated with the occurrence of gastric cancer and prognosis. |
Oncol Rep |
28849183 |
Yue Li |
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer. |
Dig Dis Sci |
30637548 |
Zhang J |
[Knockdown of YTH N(6)-methyladenosine RNA binding protein 2 (YTHDF2) inhibitsproliferation and promotes apoptosis in MGC-803 gastric cancer cells]. |
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi |
29382422 |
Cheng Zhang |
Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. |
Cancer Med |
31243897 |
Zhao Y |
m1A Regulated Genes Modulate PI3K/AKT/mTOR and ErbB Pathways in GastrointestinalCancer. |
Transl Oncol |
31352195 |
Zhang S |
m(6)A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells bySustaining FOXM1 Expression and Cell Proliferation Program. |
Cancer Cell |
28344040 |
Ai-Hua Gong |
FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells. |
Cancer Res |
25832656 |
Cui Q |
m(6)A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of GlioblastomaStem Cells. |
Cell Rep |
28297667 |
Visvanathan A |
N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for theExpression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling |
Genes (Basel) |
30781903 |
A Visvanathan |
Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
Oncogene |
28991227 |
Du-Il Jin |
Expression and roles of Wilms' tumor 1-associating protein in glioblastoma. |
Cancer Sci |
22957919 |
Zhuo Xi |
WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients. |
J Mol Neurosci |
27370540 |
F Macari |
TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. |
Oncogene |
26234676 |
Domenico Alessandro Silvestris |
Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma. |
Genome Biol |
30760294 |
Sara Tomaselli |
Modulation of microRNA editing, expression and processing by ADAR2 deaminase in glioblastoma. |
Genome Biol |
25582055 |
Lu L |
High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis inHead and Neck Squamous Carcinoma. |
Cancer Invest |
29775108 |
Sornjai W |
Hypermethylation of 28S ribosomal RNA in β-thalassemia trait carriers. |
Int J Biol Macromol |
27765567 |
Mengnuo Chen |
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. |
Hepatology |
29171881 |
Yu Zhou |
Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets. |
Cancer Manag Res |
31118805 |
Xinyao Lin |
RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of Snail. |
Nat Commun |
31061416 |
Jin-Zhao Ma |
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N -methyladenosine-dependent primary MicroRNA processing. |
Hepatology |
27774652 |
Zhe Yang |
MicroRNA-145 Modulates -Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the -Methyladenosine Binding YTH Domain Family 2 Protein. |
J Biol Chem |
28104805 |
Jiajie Hou |
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinoma. |
Mol Cancer |
31735169 |
Zhong L |
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA inhepatocellular carcinoma. |
Cancer Lett |
30423408 |
Zhao X |
Overexpression of YTHDF1 is associated with poor prognosis in patients withhepatocellular carcinoma. |
Cancer Biomark |
29439311 |
Xiaoyu Cheng |
KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNA. |
Onco Targets Ther |
31118692 |
Tian Lan |
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3. |
Mol Cancer |
31856849 |
Yunhao Chen |
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1. |
Mol Cancer |
31438961 |
Xueliang Zuo |
M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. |
J Hematol Oncol |
31915027 |
Xiuqing Dong |
CDK13 RNA Over-Editing Mediated by ADAR1 Associates with Poor Prognosis of Hepatocellular Carcinoma Patients. |
Cell Physiol Biochem |
29996118 |
Yan-Ru Qin |
Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma. |
Cancer Res |
24302582 |
Leilei Chen |
Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. |
Nat Med |
23291631 |
Yamanaka S |
A novel translational repressor mRNA is edited extensively in livers containingtumors caused by the transgene expression of the apoB mRNA-editing enzyme. |
Genes Dev |
9030685 |
Hua Su |
Transcriptome-wide map of mA circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension. |
BMC Genomics |
31931709 |
de Brouwer APM |
Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly,Short Stature, and Aggressive Behavior. |
Am J Hum Genet |
30526862 |
Julia Fischer |
Inactivation of the Fto gene protects from obesity. |
Nature |
19234441 |
Li L |
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis. |
Hum Mol Genet |
28398475 |
Ranad Shaheen |
PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly. |
Hum Genet |
30778726 |
Huiwen Song |
METTL3 and ALKBH5 oppositely regulate mA modification of mRNA, which dictates the fate of hypoxia/reoxygenation-treated cardiomyocytes. |
Autophagy |
30870073 |
Fengbiao Zhou |
AML1-ETO requires enhanced C/D box snoRNA/RNP formation to induce self-renewal and leukaemia. |
Nat Cell Biol |
28650479 |
Congcong Sun |
The study of METTL3 and METTL14 expressions in childhood ETV6/RUNX1-positive acute lymphoblastic leukemia. |
Mol Genet Genomic Med |
31429529 |
Chau-To Kwok |
Genetic alterations of mA regulators predict poorer survival in acute myeloid leukemia. |
J Hematol Oncol |
28153030 |
Ly P Vu |
The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. |
Nat Med |
28920958 |
Li Z |
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNADemethylase. |
Cancer Cell |
28017614 |
Paris J |
Targeting the RNA m(6)A Reader YTHDF2 Selectively Compromises Cancer Stem Cells inAcute Myeloid Leukemia. |
Cell Stem Cell |
31031138 |
Huang Y |
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. |
Cancer Cell |
30991027 |
Zhenrui Li |
Suppression of mA reader Ythdf2 promotes hematopoietic stem cell expansion. |
Cell Res |
30065315 |
Weng H |
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. |
Cell Stem Cell |
29290617 |
Wei Huang |
Determination of DNA and RNA Methylation in Circulating Tumor Cells by Mass Spectrometry. |
Anal Chem |
26707930 |
C Anadón |
Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis. |
Oncogene |
26640150 |
Du T |
An association study of the m6A genes with major depressive disorder in Chinese Hanpopulation. |
J Affect Disord |
26047305 |
Z Samaan |
The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. |
Mol Psychiatry |
23164817 |
Y Milaneschi |
The effect of FTO rs9939609 on major depression differs across MDD subtypes. |
Mol Psychiatry |
24492350 |
Mina S Khella |
The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study. |
Genet Test Mol Biomarkers |
29260910 |
Seungwon Yang |
mA mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. |
Nat Commun |
31239444 |
Dahal U |
RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrixmetallopeptidase 2. |
Melanoma Res |
30762711 |
Ruobing Jia |
mA modification suppresses ocular melanoma through modulating HINT2 mRNA translation. |
Mol Cancer |
31722709 |
Motoko Watanabe |
Development of metachronous rectal cancers in a young man with dyskeratosis congenita: a case report. |
J Med Case Rep |
31027506 |
Bykhovskaya Y |
Missense mutation in pseudouridine synthase 1 (PUS1) causes mitochondrial myopathyand sideroblastic anemia (MLASA). |
Am J Hum Genet |
15108122 |
Elisa Lazzari |
Alu-dependent RNA editing of GLI1 promotes malignant regeneration in multiple myeloma. |
Nat Commun |
29203771 |
Uwe Richter |
RNA modification landscape of the human mitochondrial tRNA regulates protein synthesis. |
Nat Commun |
30262910 |
Elaine deLorimier |
Pseudouridine Modification Inhibits Muscleblind-like 1 (MBNL1) Binding to CCUG Repeats and Minimally Structured RNA through Reduced RNA Flexibility. |
J Biol Chem |
28130447 |
Sandra Blanco |
Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders. |
EMBO J |
25063673 |
Mukhopadhyay D |
C-->U editing of neurofibromatosis 1 mRNA occurs in tumors that express both thetype II transcript and apobec-1, the catalytic subunit of the apolipoprotein BmRNA-editing enzyme. |
Am J Hum Genet |
11727199 |
Lin S |
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells. |
Mol Cell |
27117702 |
Du M |
MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. |
Biochem Biophys Res Commun |
27856248 |
Junho Choe |
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. |
Nature |
30232453 |
Dan Jin |
mA mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. |
J Hematol Oncol |
31818312 |
Hongsheng Wang |
N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1. |
Mol Cancer |
31823788 |
Li J |
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating them6A level of USP7 mRNA. |
Biochem Biophys Res Commun |
30905413 |
Liu J |
m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinomaby regulating MZF1 expression. |
Biochem Biophys Res Commun |
29842885 |
Sheng H |
YTH domain family 2 promotes lung cancer cell growth by facilitating6-phosphogluconate dehydrogenase mRNA translation. |
Carcinogenesis |
31504235 |
Chao Y |
ALKBH5-m(6)A-FOXM1 signaling axis promotes proliferation and invasion of lungadenocarcinoma cells under intermittent hypoxia. |
Biochem Biophys Res Commun |
31677788 |
Zhu Z |
N(6)-methyladenosine ALKBH5 promotes non-small cell lung cancer progress byregulating TIMP3 stability. |
Gene |
31927006 |
Michael P Guy |
Defects in tRNA Anticodon Loop 2'-O-Methylation Are Implicated in Nonsyndromic X-Linked Intellectual Disability due to Mutations in FTSJ1. |
Hum Mutat |
26310293 |
Lu Qi |
Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. |
Diabetes |
18647953 |
Vladimir Babenko |
FTO haplotyping underlines high obesity risk for European populations. |
BMC Med Genomics |
30871540 |
Scuteri A |
Genome-wide association scan shows genetic variants in the FTO gene are associatedwith obesity-related traits. |
PLoS Genet |
17658951 |
Yunshu Wu |
Mettl3-mediated mA RNA methylation regulates the fate of bone marrow mesenchymal stem cells and osteoporosis. |
Nat Commun |
30429466 |
Miao W |
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating them6A level of LEF1. |
Biochem Biophys Res Commun |
31253399 |
Woo HH |
Human ALKBH3-induced m(1)A demethylation increases the CSF-1 mRNA stability inbreast and ovarian cancer cells. |
Biochim Biophys Acta Gene Regul Mech |
30342176 |
Kosuke Taketo |
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells. |
Int J Oncol |
29345285 |
Jixiang Chen |
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. |
Cell Cycle |
29135329 |
Daniele Fanale |
Germline copy number variation in the YTHDC2 gene: does it have a role in finding a novel potential molecular target involved in pancreatic adenocarcinoma susceptibility? |
Expert Opin Ther Targets |
24834797 |
Yuan He |
ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 Methylation. |
Cell Physiol Biochem |
30032148 |
Bo Tang |
mA demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. |
Mol Cancer |
31906946 |
Xuechai Chen |
Down-Regulation of m6A mRNA Methylation Is Involved in Dopaminergic Neuronal Death. |
ACS Chem Neurosci |
30835997 |
Wettengel J |
Harnessing human ADAR2 for RNA repair - Recoding a PINK1 mutation rescues mitophagy. |
Nucleic Acids Res |
27907896 |
Chenyue Ding |
Increased N6-methyladenosine causes infertility is associated with FTO expression. |
J Cell Physiol |
29384212 |
Jiangfeng Li |
Downregulation of N-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N-methyladenosine levels. |
Oncotarget |
29423080 |
Jiarong Cai |
RNA mA Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway. |
Onco Targets Ther |
31806999 |
Richard T O'Neil |
Quantitative analysis of 5HT(2C) receptor RNA editing patterns in psychiatric disorders. |
Neurobiol Dis |
21914481 |
Xiao Li |
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma. |
Oncotarget |
29221190 |
Dongkui Gong |
The mA-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. |
J Exp Clin Cancer Res |
31159832 |
Changshui Zhuang |
N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. |
J Cell Mol Med |
30648791 |
Jingyuan Tang |
Wilms' tumor 1-associating protein promotes renal cell carcinoma proliferation by regulating CDK2 mRNA stability. |
J Exp Clin Cancer Res |
29482572 |
Ahmadreza Niavarani |
APOBEC3A is implicated in a novel class of G-to-A mRNA editing in WT1 transcripts. |
PLoS One |
25807502 |
Brusa R |
Early-onset epilepsy and postnatal lethality associated with an editing-deficientGluR-B allele in mice. |
Science |
7502080 |
Alessandro Barbon |
Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. |
J Neurochem |
20456005 |
Svenja Kankowski |
A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy. |
Front Mol Neurosci |
29375302 |
Gonzales B |
The Treacher Collins syndrome (TCOF1) gene product is involved in pre-rRNAmethylation. |
Hum Mol Genet |
15930015 |
Frayling TM |
A common variant in the FTO gene is associated with body mass index and predisposesto childhood and adult obesity. |
Science |
17434869 |
Dario F De Jesus |
mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes. |
Nat Metab |
31867565 |
Oscar Franzén |
Global analysis of A-to-I RNA editing reveals association with common disease variants. |
PeerJ |
29527417 |
Chen X |
5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs |
Nat Cell Biol . |
31358969 |
Shinichiro Akichika |
Cap-specific terminal -methylation of RNA by an RNA polymerase II-associated methyltransferase. |
Science |
30467178 |
Hanxiao Sun |
Cap-specific, terminal N-methylation by a mammalian mAm methyltransferase. |
Cell Res |
30487554 |
Konstantinos Boulias |
Identification of the mAm Methyltransferase PCIF1 Reveals the Location and Functions of mAm in the Transcriptome. |
Mol Cell |
31279658 |
Erdem Sendinc |
PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression. |
Mol Cell |
31279659 |
Nhan van Tran |
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112. |
Nucleic Acids Res |
31328227 |
Valentina V Ignatova |
The rRNA mA methyltransferase METTL5 is involved in pluripotency and developmental programs. |
Genes Dev |
32217665 |
Honghui Ma |
NMethyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation. |
Nat Chem Biol |
30531910 |
Rita Pinto |
The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA. |
Nucleic Acids Res |
31799605 |
Wendan Ren |
Structure and regulation of ZCCHC4 in mA-methylation of 28S rRNA. |
Nat Commun |
31695039 |
Hao Chen |
METTL4 is an snRNA mAm methyltransferase that regulates RNA splicing. |
Cell Res |
31913360 |
Ziyang Hao |
N-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA. |
Mol Cell |
32183942 |
Martin Müller |
Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. |
RNA Biol |
30646830 |
Maria Becker |
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. |
Nucleic Acids Res |
23074192 |
J G Tokuhisa |
Chloroplast development at low temperatures requires a homolog of DIM1, a yeast gene encoding the 18S rRNA dimethylase. |
Plant Cell |
9596631 |
Jun-Ichi Wachino |
RmtC introduces G1405 methylation in 16S rRNA and confers high-level aminoglycoside resistance on Gram-positive microorganisms. |
FEMS Microbiol Lett |
20722735 |
Meisam Nosrati |
Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition. |
J Biol Chem |
31594862 |
Alena Stsiapanava |
Crystal structure of ErmE - 23S rRNA methyltransferase in macrolide resistance. |
Sci Rep |
31601908 |
I D Villsen |
ErmE methyltransferase recognizes features of the primary and secondary structure in a motif within domain V of 23 S rRNA. |
J Mol Biol |
9973557 |
B Vester |
Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase. |
J Bacteriol |
7961464 |
B Vester |
The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase. |
RNA |
7489511 |
Jean-Michel Carter |
FICC-Seq: a method for enzyme-specified profiling of methyl-5-uridine in cellular RNA. |
Nucleic Acids Res |
31361898 |
Marisa Pereira |
mU54 tRNA Hypomodification by Lack of TRMT2A Drives the Generation of tRNA-Derived Small RNAs. |
Int J Mol Sci |
33799331 |
Christopher A Powell |
TRMT2B is responsible for both tRNA and rRNA mU-methylation in human mitochondria. |
RNA Biol |
31948311 |
Ivan Laptev |
Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for mU formation in both tRNA and rRNA. |
RNA Biol |
31736397 |
Jahangir Alam |
Expression and analysis of the SAM-dependent RNA methyltransferase Rsm22 from Saccharomyces cerevisiae. |
Acta Crystallogr D Struct Biol |
34076597 |
Meijuan Zou |
The critical function of the plastid rRNA methyltransferase, CMAL, in ribosome biogenesis and plant development. |
Nucleic Acids Res |
32095829 |
Lindsey Van Haute |
METTL15 introduces N4-methylcytidine into human mitochondrial 12S rRNA and is required for mitoribosome biogenesis. |
Nucleic Acids Res |
31665743 |
Hao Chen |
The human mitochondrial 12S rRNA mC methyltransferase METTL15 is required for mitochondrial function. |
J Biol Chem |
32371392 |
Ivan Laptev |
METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m4C840 12S rRNA residue. |
Nucleic Acids Res |
32573735 |
Jason D Arroyo |
A Genome-wide CRISPR Death Screen Identifies Genes Essential for Oxidative Phosphorylation. |
Cell Metab |
27667664 |
Shaoni Mukhopadhyay |
Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA. |
RNA |
33023933 |
Modi Safra |
TRUB1 is the predominant pseudouridine synthase acting on mammalian mRNA via a predictable and conserved code. |
Genome Res |
28073919 |
Xue-Ling Mao |
Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6. |
Nucleic Acids Res |
34268557 |
Nikoletta A Gkatza |
Cytosine-5 RNA methylation links protein synthesis to cell metabolism. |
PLoS Biol |
31199786 |
Xiaotian Zhang |
The tRNA methyltransferase NSun2 stabilizes p16INK⁴ mRNA by methylating the 3'-untranslated region of p16. |
Nat Commun |
22395603 |
Abdulrahim A Sajini |
Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation. |
Nat Commun |
31186410 |
Jinghui Song |
Differential roles of human PUS10 in miRNA processing and tRNA pseudouridylation. |
Nat Chem Biol |
31819270 |
Manisha Deogharia |
The human ortholog of archaeal Pus10 produces pseudouridine 54 in select tRNAs where its recognition sequence contains a modified residue. |
RNA |
30530625 |
Zuxiao Yang |
Functional organization of box C/D RNA-guided RNA methyltransferase. |
Nucleic Acids Res |
32297938 |
Xiaodan Liu |
Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. |
Nucleic Acids Res |
31251801 |
Dan Bar-Yaacov |
Mitochondrial 16S rRNA Is Methylated by tRNA Methyltransferase TRMT61B in All Vertebrates. |
PLoS Biol |
27631568 |
Nathan W Howell |
Distinct substrate specificities of the human tRNA methyltransferases TRMT10A and TRMT10B. |
RNA |
31292261 |
Y Nagayoshi |
Loss of Ftsj1 perturbs codon-specific translation efficiency in the brain and is associated with X-linked intellectual disability. |
Sci Adv |
33771871 |
J M Lentini |
1 METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs |
|
https://www.biorxiv.org/content/10.1101/2021.05.02 |
Konstantin A Ivanov |
Multiple enzymatic activities associated with severe acute respiratory syndrome coronavirus helicase. |
J Virol |
15140959 |
Liming Yan |
Cryo-EM Structure of an Extended SARS-CoV-2 Replication and Transcription Complex Reveals an Intermediate State in Cap Synthesis. |
Cell |
33232691 |
Souradeep Basu |
Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp14 RNA cap methyltransferase. |
Biochem J |
34198328 |
Sheng Lin |
Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity. |
Nucleic Acids Res |
33956156 |
Aliakbar Khalili Yazdi |
A High-Throughput Radioactivity-Based Assay for Screening SARS-CoV-2 nsp10-nsp16 Complex. |
SLAS Discov |
33874769 |
Christopher Piccirillo |
Functional characterization of the mammalian mRNA decapping enzyme hDcp2. |
RNA |
12923261 |
Erwin van Dijk |
Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures. |
EMBO J |
12486012 |
Man-Gen Song |
Multiple mRNA decapping enzymes in mammalian cells. |
Mol Cell |
21070968 |
S Kramer |
The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes |
PLoS Pathog |
28628654 |
L Clemmesen |
Local cerebral glucose consumption during ethanol withdrawal in the rat: effects of single and multiple episodes and previous convulsive seizures. |
Brain Res |
3401759 |
S Onesti |
The crystal structure of the lysyl-tRNA synthetase (LysU) from Escherichia coli. |
Structure |
7735833 |
Daniel J Luciano |
Stresses that Raise NpA Levels Induce Protective Nucleoside Tetraphosphate Capping of Bacterial RNA. |
Mol Cell |
31178354 |
Yaqing Zhang |
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. |
Nat Commun |
33139726 |
Ewa Grudzien-Nogalska |
"NAD-capQ" detection and quantitation of NAD caps. |
RNA |
30045887 |
Xinfu Jiao |
Identification of a quality-control mechanism for mRNA 5'-end capping. |
Nature |
20802481 |
S R AbdelRaheim |
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. |
Arch Biochem Biophys |
11361135 |
Xinfu Jiao |
5' End Nicotinamide Adenine Dinucleotide Cap in Human Cells Promotes RNA Decay through DXO-Mediated deNADding. |
Cell |
28283058 |
Ewa Grudzien-Nogalska |
Structural and mechanistic basis of mammalian Nudt12 RNA deNADding. |
Nat Chem Biol |
31101919 |
F Picard-Jean |
2'-O-methylation of the mRNA cap protects RNAs from decapping and degradation by DXO |
PLoS One |
29601584 |
Petra Krafcikova |
Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin. |
Nat Commun |
32709887 |
Monica Rosas-Lemus |
High-resolution structures of the SARS-CoV-2 2'--methyltransferase reveal strategies for structure-based inhibitor design. |
Sci Signal |
32994211 |
Yujiro Nishizawa |
Oncogene c-Myc promotes epitranscriptome mA reader YTHDF1 expression in colorectal cancer. |
Oncotarget |
29484125 |
Y Bai |
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal Carcinoma |
Front Oncol. |
31131257 |
S Lin |
METTL3 Promotes the Proliferation and Mobility of Gastric Cancer Cells |
Open Med (Wars) |
30886897 |
Tong Liu |
Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancer. |
J Cell Physiol |
31232471 |
Dong Xu |
FTO expression is associated with the occurrence of gastric cancer and prognosis. |
Oncol Rep |
28849183 |
Yue Li |
Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer. |
Dig Dis Sci |
30637548 |
Abhirami Visvanathan |
N⁶-Methyladenosine Landscape of Glioma Stem-Like Cells: METTL3 Is Essential for the Expression of Actively Transcribed Genes and Sustenance of the Oncogenic Signaling. |
Genes (Basel) |
30781903 |
A Visvanathan |
Essential role of METTL3-mediated mA modification in glioma stem-like cells maintenance and radioresistance. |
Oncogene |
28991227 |
Du-Il Jin |
Expression and roles of Wilms' tumor 1-associating protein in glioblastoma. |
Cancer Sci |
22957919 |
Zhuo Xi |
WTAP Expression Predicts Poor Prognosis in Malignant Glioma Patients. |
J Mol Neurosci |
27370540 |
X Zhao |
Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinoma |
Cancer Biomark . |
29439311 |
Y Zhou |
Expression profiles and prognostic significance of RNA N6-methyladenosine-related genes in patients with hepatocellular carcinoma: evidence from independent datasets |
Cancer Manag Res. |
31118805 |
Z Samaan |
The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. |
Mol Psychiatry |
23164817 |
Y Milaneschi |
The effect of FTO rs9939609 on major depression differs across MDD subtypes. |
Mol Psychiatry |
24492350 |
Qiyao Zhang |
Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues. |
J Transl Med |
32571340 |
Yuanbo Hu |
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation. |
Cell Death Dis |
34504059 |
Ruimeng Yang |
The RNA methyltransferase NSUN6 suppresses pancreatic cancer development by regulating cell proliferation. |
EBioMedicine |
33418496 |
Liuhong Shi |
N1-methyladenosine profiling of long non-coding RNA in colorectal cancer. |
IUBMB Life |
34314547 |
Rosaura Esteve-Puig |
Epigenetic loss of m1A RNA demethylase ALKBH3 in Hodgkin lymphoma targets collagen, conferring poor clinical outcome. |
Blood |
32915956 |