Modomics - A Database of RNA Modifications

First Author Title Journal Title PubMed ID / DOI
Hausmann S Giardia lamblia RNA cap guanine-N2 methyltransferase (Tgs2). J Biol Chem 16046409
Urbonavicius J Identification of a novel gene encoding a flavin-dependent tRNA:m5U methyltransferase in bacteria--evolutionary implications. Nucleic Acids Res 16027442
Marmier-Gourrier N A structural, phylogenetic, and functional study of 15.5-kD/Snu13 protein binding on U3 small nucleolar RNA. RNA 12810916
Hager J Substrate binding analysis of the 23S rRNA methyltransferase RrmJ. J Bacteriol 15375145
Sunita S Functional specialization of domains tandemly duplicated within 16S rRNA methyltransferase RsmC. Nucleic Acids Res 17576679
Kolodrubetz D Sequence and genetic analysis of NHP2: a moderately abundant high mobility group-like nuclear protein with an essential function in Saccharomyces cerevisiae. Yeast 2063628
Motorin Y Multisite-specific tRNA:m5C-methyltransferase (Trm4) in yeast Saccharomyces cerevisiae: identification of the gene and substrate specificity of the enzyme. RNA 10445884
Walbott H Cysteine of sequence motif VI is essential for nucleophilic catalysis by yeast tRNA m5C methyltransferase. RNA 17475914
Motorin Y The yeast tRNA:pseudouridine synthase Pus1p displays a multisite substrate specificity. RNA 9671058
Behm-Ansmant I The Saccharomyces cerevisiae U2 snRNA:pseudouridine-synthase Pus7p is a novel multisite-multisubstrate RNA:Psi-synthase also acting on tRNAs. RNA 14561887
Grosjean H Aminoacylation of the anticodon stem by a tRNA-synthetase paralog: relic of an ancient code? Trends Biochem Sci 15450604
Behm-Ansmant I The Saccharomyces cerevisiae Pus2 protein encoded by YGL063w ORF is a mitochondrial tRNA:Psi27/28-synthase. RNA 17684231
Kotelawala L Identification of yeast tRNA Um(44) 2'-O-methyltransferase (Trm44) and demonstration of a Trm44 role in sustaining levels of specific tRNA(Ser) species. RNA 18025252
Ikeuchi Y The RNA acetyltransferase driven by ATP hydrolysis synthesizes N4-acetylcytidine of tRNA anticodon. EMBO J 18668122
Kambampati R IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. Biochemistry 10600118
Bujnicki JM Bioinformatic analyses of the tRNA: (guanine 26, N2,N2)-dimethyltransferase (Trm1) family. J Mol Microbiol Biotechnol 12125821
Purushothaman SK Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol Cell Biol 15899842
Hamilton CS Mechanistic investigations of the pseudouridine synthase RluA using RNA containing 5-fluorouridine. Biochemistry 17002302
Bujnicki JM Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase. J Mol Evol 12355263
de Beus E Yeast NOP2 encodes an essential nucleolar protein with homology to a human proliferation marker. J Cell Biol 7806561
Wolfe MD Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. J Biol Chem 14594807
Jiang W An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. Mol Cell Biol 8336724
Salazar JC A truncated aminoacyl-tRNA synthetase modifies RNA. Proc Natl Acad Sci U S A 15096612
Pierrel F MiaB protein is a bifunctional radical-S-adenosylmethionine enzyme involved in thiolation and methylation of tRNA. J Biol Chem 15339930
Roovers M A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase. Nucleic Acids Res 14739239
Hallberg BM The structure of the RNA m5C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain. J Mol Biol 16793063
Pintard L MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. EMBO J 11867542
Caldas T The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. J Biol Chem 10748051
Hausmann S Specificity and mechanism of RNA cap guanine-N2 methyltransferase (Tgs1). J Biol Chem 15590684
Frey B New function of vitamin B12: cobamide-dependent reduction of epoxyqueuosine to queuosine in tRNAs of Escherichia coli and Salmonella typhimurium. J Bacteriol 3129401
Wrzesinski J Purification, cloning, and properties of the 16S RNA pseudouridine 516 synthase from Escherichia coli. Biochemistry 7612632
Mouaikel J Hypermethylation of the cap structure of both yeast snRNAs and snoRNAs requires a conserved methyltransferase that is localized to the nucleolus. Mol Cell 11983179
Romanowski MJ Crystal structure of the Escherichia coli glucose-inhibited division protein B (GidB) reveals a methyltransferase fold. Proteins 12001236
Cabedo H The Escherichia coli trmE (mnmE) gene, involved in tRNA modification, codes for an evolutionarily conserved GTPase with unusual biochemical properties. EMBO J 10601028
Clery A Analysis of sequence and structural features that identify the B/C motif of U3 small nucleolar RNA as the recognition site for the Snu13p-Rrp9p protein pair. Mol Cell Biol 17145781
Jacq C The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature 9169867
Kato T A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis. Cancer Res 15994936
Watanabe M Biosynthesis of archaeosine, a novel derivative of 7-deazaguanosine specific to archaeal tRNA, proceeds via a pathway involving base replacement on the tRNA polynucleotide chain. J Biol Chem 9242689
Lapeyre B Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage. Mol Cell 15546625
Pintard L Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. EMBO J 11927565
Agarwalla S Characterization of the 23 S ribosomal RNA m5U1939 methyltransferase from Escherichia coli. J Biol Chem 11779873
Massenet S Pseudouridine mapping in the Saccharomyces cerevisiae spliceosomal U small nuclear RNAs (snRNAs) reveals that pseudouridine synthase pus1p exhibits a dual substrate specificity for U2 snRNA and tRNA. Mol Cell Biol 10022901
Hagervall TG Genetic mapping and cloning of the gene (trmC) responsible for the synthesis of tRNA (mnm5s2U)methyltransferase in Escherichia coli K12. Mol Gen Genet 6387395
Lesnyak DV Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. J Biol Chem 17189261
Kalhor HR Novel methyltransferase for modified uridine residues at the wobble position of tRNA. Mol Cell Biol 14645538
Grimm C Crystal structure of Bacillus subtilis S-adenosylmethionine:tRNA ribosyltransferase-isomerase. Biochem Biophys Res Commun 17083917
Noma A Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA. EMBO J 16642040
Bonnerot C Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast. Mol Cell 14636587
Decoster E MSS1, a nuclear-encoded mitochondrial GTPase involved in the expression of COX1 subunit of cytochrome c oxidase. J Mol Biol 8392589
Gu XR Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. Biochemistry 10194318
Del Campo M Identification and site of action of the remaining four putative pseudouridine synthases in Escherichia coli. RNA 11720289
Slany RK A new function of S-adenosylmethionine: the ribosyl moiety of AdoMet is the precursor of the cyclopentenediol moiety of the tRNA wobble base queuine. Biochemistry 8347586
Soma A An RNA-modifying enzyme that governs both the codon and amino acid specificities of isoleucine tRNA. Mol Cell 14527414
De Bie LG The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase. J Bacteriol 12730187
Brisson-Noel A Evidence for natural gene transfer from gram-positive cocci to Escherichia coli. J Bacteriol 2832378
Michel G The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot. Structure 12377117
Watanabe K Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltransferase) enzymes. J Biol Chem 16963456
Gutgsell N Deletion of the Escherichia coli pseudouridine synthase gene truB blocks formation of pseudouridine 55 in tRNA in vivo, does not affect exponential growth, but confers a strong selective disadvantage in competition with wild-type cells. RNA 11142385
Jager G The conserved Cys-X1-X2-Cys motif present in the TtcA protein is required for the thiolation of cytidine in position 32 of tRNA from Salmonella enterica serovar Typhimurium. J Bacteriol 14729701
Bujnicki JM Sequence-structure-function studies of tRNA:m5C methyltransferase Trm4p and its relationship to DNA:m5C and RNA:m5U methyltransferases. Nucleic Acids Res 15121902
Hagervall TG Transfer RNA(5-methylaminomethyl-2-thiouridine)-methyltransferase from Escherichia coli K-12 has two enzymatic activities. J Biol Chem 3298234
Stengl B Mechanism and substrate specificity of tRNA-guanine transglycosylases (TGTs): tRNA-modifying enzymes from the three different kingdoms of life share a common catalytic mechanism. Chembiochem 16206323
Bussey H The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. Nature 9169875
Calvo O GCD14p, a repressor of GCN4 translation, cooperates with Gcd10p and Lhp1p in the maturation of initiator methionyl-tRNA in Saccharomyces cerevisiae. Mol Cell Biol 10330157
Tsukamoto T Isolation and characterization of the yeast mRNA capping enzyme beta subunit gene encoding RNA 5'-triphosphatase, which is essential for cell viability. Biochem Biophys Res Commun 9345280
Lauhon CT Substitutions in an active site loop of Escherichia coli IscS result in specific defects in Fe-S cluster and thionucleoside biosynthesis in vivo. J Biol Chem 14978044
Gutgsell NS A second function for pseudouridine synthases: A point mutant of RluD unable to form pseudouridines 1911, 1915, and 1917 in Escherichia coli 23S ribosomal RNA restores normal growth to an RluD-minus strain. RNA 11453071
Kressler D Spb1p is a putative methyltransferase required for 60S ribosomal subunit biogenesis in Saccharomyces cerevisiae. Nucleic Acids Res 10556316
Toh SM The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. RNA 18025251
Lesnyak DV Identification of Escherichia coli m2G methyltransferases: I. the ycbY gene encodes a methyltransferase specific for G2445 of the 23 S rRNA. J Mol Biol 17010378
Yim L The GTPase activity and C-terminal cysteine of the Escherichia coli MnmE protein are essential for its tRNA modifying function. J Biol Chem 12730230
Wolf J tadA, an essential tRNA-specific adenosine deaminase from Escherichia coli. EMBO J 12110595
Wu P Nop5p is a small nucleolar ribonucleoprotein component required for pre-18 S rRNA processing in yeast. J Biol Chem 9632712
Watanabe K Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family. J Biol Chem 15637073
Caillet J Molecular cloning of the Escherichia coli miaA gene involved in the formation of delta 2-isopentenyl adenosine in tRNA. J Bacteriol 3045085
Waas WF Discovery of a gene family critical to wyosine base formation in a subset of phenylalanine-specific transfer RNAs. J Biol Chem 16162496
Gutgsell NS The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coli. RNA 15928344
Lauhon CT Requirement for IscS in biosynthesis of all thionucleosides in Escherichia coli. J Bacteriol 12446632
Hopper AK tRNA transfers to the limelight. Genes Dev 12533506
Baker DL RNA-guided RNA modification: functional organization of the archaeal H/ACA RNP. Genes Dev 15870259
Gustafsson C Identification of the rrmA gene encoding the 23S rRNA m1G745 methyltransferase in Escherichia coli and characterization of an m1G745-deficient mutant. J Bacteriol 9440525
Leinfelder W In vitro synthesis of selenocysteinyl-tRNA(UCA) from seryl-tRNA(UCA): involvement and characterization of the selD gene product. Proc Natl Acad Sci U S A 2405383
Basturea GN Identification and characterization of RsmE, the founding member of a new RNA base methyltransferase family. RNA 16431987
Mathews I Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. Proteins 15822125
Ny T Cloning and restriction mapping of the trmA gene coding for transfer ribonucleic acid (5-methyluridine)-methyltransferase in Escherichia coli K-12. J Bacteriol 6247318
Nordlund ME Identification of the TRM2 gene encoding the tRNA(m5U54)methyltransferase of Saccharomyces cerevisiae. RNA 10864043
Appel CD Structural features of the guide:target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2'-O-methylation. RNA 17438123
Xing F The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. J Biol Chem 14970222
Rozenski J The RNA Modification Database: 1999 update. Nucleic Acids Res 9847178
Swairjo MA Crystallization and preliminary X-ray characterization of the nitrile reductase QueF: a queuosine-biosynthesis enzyme. Acta Crystallogr Sect F Struct Biol Cryst Commun 16511203
Campanacci V The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity. J Mol Biol 15003446
Bishop AC Identification of the tRNA-dihydrouridine synthase family. J Biol Chem 11983710
Gerber AP An adenosine deaminase that generates inosine at the wobble position of tRNAs. Science 10550050
Nakanishi K Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain. Proc Natl Acad Sci U S A 15894617
Tettelin H The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature 9169869
Hamma T The Cbf5-Nop10 complex is a molecular bracket that organizes box H/ACA RNPs. Nat Struct Mol Biol 16286935
Blaise M Glu-Q-tRNA(Asp) synthetase coded by the yadB gene, a new paralog of aminoacyl-tRNA synthetase that glutamylates tRNA(Asp) anticodon. Biochimie 16164993
Yim L Further insights into the tRNA modification process controlled by proteins MnmE and GidA of Escherichia coli. Nucleic Acids Res 17062623
Lee TT A unique RNA Fold in the RumA-RNA-cofactor ternary complex contributes to substrate selectivity and enzymatic function. Cell 15766524
Cupp-Vickery JR Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli. J Mol Biol 15050828
Nasvall SJ The modified wobble nucleoside uridine-5-oxyacetic acid in tRNAPro(cmo5UGG) promotes reading of all four proline codons in vivo. RNA 15383682
Philippsen P The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Nature 9169873
Esberg B Identification of the miaB gene, involved in methylthiolation of isopentenylated A37 derivatives in the tRNA of Salmonella typhimurium and Escherichia coli. J Bacteriol 10572129
Ollagnier-de-Choudens S Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin. J Biol Chem 11319236
Bujnicki JM Sequence analysis and structure prediction of 23S rRNA:m1G methyltransferases reveals a conserved core augmented with a putative Zn-binding domain in the N-terminus and family-specific elaborations in the C-terminus. J Mol Microbiol Biotechnol 11763974
Henras A Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. EMBO J 9843512
Girard JP GAR1 is an essential small nucleolar RNP protein required for pre-rRNA processing in yeast. EMBO J 1531632
Purta E Sequence-structure-function relationships of a tRNA (m7G46) methyltransferase studied by homology modeling and site-directed mutagenesis. Proteins 15789416
Alexandrov A Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA. RNA 12403464
Zhang X The coiled-coil domain of the Nop56/58 core protein is dispensable for sRNP assembly but is critical for archaeal box C/D sRNP-guided nucleotide methylation. RNA 16601205
Hellmuth K Cloning and characterization of the Schizosaccharomyces pombe tRNA:pseudouridine synthase Pus1p. Nucleic Acids Res 11095668
Ozanick S The bipartite structure of the tRNA m1A58 methyltransferase from S. cerevisiae is conserved in humans. RNA 16043508
Ansmant I Identification of the Saccharomyces cerevisiae RNA:pseudouridine synthase responsible for formation of psi(2819) in 21S mitochondrial ribosomal RNA. Nucleic Acids Res 10756195
Bujnicki JM In silico analysis of the tRNA:m1A58 methyltransferase family: homology-based fold prediction and identification of new members from Eubacteria and Archaea. FEBS Lett 11684083
Anderson J The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA. Genes Dev 9851972
Wilkinson ML The 2'-O-methyltransferase responsible for modification of yeast tRNA at position 4. RNA 17242307
Bujnicki JM Phylogenomic analysis of 16S rRNA:(guanine-N2) methyltransferases suggests new family members and reveals highly conserved motifs and a domain structure similar to other nucleic acid amino-methyltransferases. FASEB J 11053259
Bystrom AS The structural gene (trmD) for the tRNA(m1G)methyltransferase is part of a four polypeptide operon in Escherichia coli K-12. Mol Gen Genet 6298574
Dong X Crystal structure of tRNA pseudouridine synthase TruA from Thermus thermophilus HB8. RNA Biol 17114947
Suzuki Y Crystal structure of the radical SAM enzyme catalyzing tricyclic modified base formation in tRNA. J Mol Biol 17727881
Motorin Y Transfer RNA recognition by the Escherichia coli delta2-isopentenyl-pyrophosphate:tRNA delta2-isopentenyl transferase: dependence on the anticodon arm structure. RNA 9214656
Astrom SU Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. Cell 7954819
Bjork GR Genetic dissection of synthesis and function of modified nucleosides in bacterial transfer RNA. Prog Nucleic Acid Res Mol Biol 7538683
Pan H The crystal structure of E. coli rRNA pseudouridine synthase RluE. J Mol Biol 17320904
Dubois DY An aminoacyl-tRNA synthetase-like protein encoded by the Escherichia coli yadB gene glutamylates specifically tRNAAsp. Proc Natl Acad Sci U S A 15096594
Soderberg T Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop. Biochemistry 10828971
Lafontaine D The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast. Genes Dev 7590228
Hur S How U38, 39, and 40 of many tRNAs become the targets for pseudouridylation by TruA. Mol Cell 17466622
Schubot FD Crystal structure of the transcription factor sc-mtTFB offers insights into mitochondrial transcription. Protein Sci 11567089
Anderson J The Gcd10p/Gcd14p complex is the essential two-subunit tRNA(1-methyladenosine) methyltransferase of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 10779558
Dihanich ME Isolation and characterization of MOD5, a gene required for isopentenylation of cytoplasmic and mitochondrial tRNAs of Saccharomyces cerevisiae. Mol Cell Biol 3031456
Kaya Y A novel unanticipated type of pseudouridine synthase with homologs in bacteria, archaea, and eukarya. RNA 12756329
Kalhor HR Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast. Arch Biochem Biophys 11697862
Roovers M Formation of the conserved pseudouridine at position 55 in archaeal tRNA. Nucleic Acids Res 16920741
Bujnicki JM Sequence analysis and structure prediction of aminoglycoside-resistance 16S rRNA:m7G methyltransferases. Acta Microbiol Pol 11518396
Vaidyanathan PP RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA. RNA 17872507
Kolman C SPL1-1, a Saccharomyces cerevisiae mutation affecting tRNA splicing. J Bacteriol 8444805
Johansson MJ The Saccharomyces cerevisiae TAN1 gene is required for N4-acetylcytidine formation in tRNA. RNA 15037780
Bugl H RNA methylation under heat shock control. Mol Cell 10983982
McCleverty CJ Crystal structure of human Pus10, a novel pseudouridine synthase. J Mol Biol 17900615
Basturea GN Substrate specificity and properties of the Escherichia coli 16S rRNA methyltransferase, RsmE. RNA 17872509
Taylor AB The crystal structure of Nep1 reveals an extended SPOUT-class methyltransferase fold and a pre-organized SAM-binding site. Nucleic Acids Res 18208838
Persson BC The spoU gene of Escherichia coli, the fourth gene of the spoT operon, is essential for tRNA (Gm18) 2'-O-methyltransferase activity. Nucleic Acids Res 9321663
Leipuviene R Formation of thiolated nucleosides present in tRNA from Salmonella enterica serovar Typhimurium occurs in two principally distinct pathways. J Bacteriol 14729702
Wachino J Novel plasmid-mediated 16S rRNA m1A1408 methyltransferase, NpmA, found in a clinically isolated Escherichia coli strain resistant to structurally diverse aminoglycosides. Antimicrob Agents Chemother 17875999
Pintard L Spb1p is a yeast nucleolar protein associated with Nop1p and Nop58p that is able to bind S-adenosyl-L-methionine in vitro. Mol Cell Biol 10648622
Behm-Ansmant I Pseudouridylation at position 32 of mitochondrial and cytoplasmic tRNAs requires two distinct enzymes in Saccharomyces cerevisiae. J Biol Chem 15466869
Kambampati R MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. Biochemistry 12549933
Andersen NM YebU is a m5C methyltransferase specific for 16 S rRNA nucleotide 1407. J Mol Biol 16678201
Purta E YbeA is the m3Psi methyltransferase RlmH that targets nucleotide 1915 in 23S rRNA. RNA 18755835
Matte A Structure of the pseudouridine synthase RsuA from Haemophilus influenzae. Acta Crystallogr Sect F Struct Biol Cryst Commun 16511038
Okamoto S Loss of a conserved 7-methylguanosine modification in 16S rRNA confers low-level streptomycin resistance in bacteria. Mol Microbiol 17238915
Teplova M The structure of the yrdC gene product from Escherichia coli reveals a new fold and suggests a role in RNA binding. Protein Sci 11206077
Caldas T Translational defects of Escherichia coli mutants deficient in the Um(2552) 23S ribosomal RNA methyltransferase RrmJ/FTSJ. Biochem Biophys Res Commun 10814528
Conrad J The rluC gene of Escherichia coli codes for a pseudouridine synthase that is solely responsible for synthesis of pseudouridine at positions 955, 2504, and 2580 in 23 S ribosomal RNA. J Biol Chem 9660827
Carnahan RH Dim1p is required for efficient splicing and export of mRNA encoding lid1p, a component of the fission yeast anaphase-promoting complex. Eukaryot Cell 15755920
Cupp-Vickery JR Crystal structure of IscS, a cysteine desulfurase from Escherichia coli. J Mol Biol 12860127
Xing F A conserved family of Saccharomyces cerevisiae synthases effects dihydrouridine modification of tRNA. RNA 12003496
Kalhor HR A novel methyltransferase required for the formation of the hypermodified nucleoside wybutosine in eucaryotic tRNA. Biochem Biophys Res Commun 16005430
Cavaille J The yeast Saccharomyces cerevisiae YDL112w ORF encodes the putative 2'-O-ribose methyltransferase catalyzing the formation of Gm18 in tRNAs. RNA 9917067
Elkins PA Insights into catalysis by a knotted TrmD tRNA methyltransferase. J Mol Biol 14583191
Purta E The yfhQ gene of Escherichia coli encodes a tRNA:Cm32/Um32 methyltransferase. BMC Mol Biol 16848900
Na JG Isolation and characterization of SUA5, a novel gene required for normal growth in Saccharomyces cerevisiae. Genetics 1325384
Sergiev PV The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel. J Mol Biol 18021804
Bjork GR A primordial tRNA modification required for the evolution of life? EMBO J 11226173
Colby G MTO1 codes for a mitochondrial protein required for respiration in paromomycin-resistant mutants of Saccharomyces cerevisiae. J Biol Chem 9774408
Matsumoto K RNA recognition mechanism of eukaryote tRNA (m7G46) methyltransferase (Trm8-Trm82 complex). FEBS Lett 17382321
Tomoyasu T The Escherichia coli FtsH protein is a prokaryotic member of a protein family of putative ATPases involved in membrane functions, cell cycle control, and gene expression. J Bacteriol 8444796
Reuter K Structure and organization of Escherichia coli genes involved in biosynthesis of the deazaguanine derivative queuine, a nutrient factor for eukaryotes. J Bacteriol 1706703
Madsen CT Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry. Nucleic Acids Res 12907714
Pan H Structure of tRNA pseudouridine synthase TruB and its RNA complex: RNA recognition through a combination of rigid docking and induced fit. Proc Natl Acad Sci U S A 14566049
Hong B Nop2p is required for pre-rRNA processing and 60S ribosome subunit synthesis in yeast. Mol Cell Biol 8972218
Reynaud A Disruption and functional analysis of six ORFs of chromosome IV: YDL103c (QRI1), YDL105w (QRI2), YDL112w (TRM3), YDL113c, YDL116w (NUP84) and YDL167c (NRP1). Yeast 11180460
Tkaczuk KL Structural and evolutionary bioinformatics of the SPOUT superfamily of methyltransferases. BMC Bioinformatics 17338813
Clancy MJ Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. Nucleic Acids Res 12384598
Mueller EG Identification of a gene involved in the generation of 4-thiouridine in tRNA. Nucleic Acids Res 9592144
Jablonowski D tRNAGlu wobble uridine methylation by Trm9 identifies Elongator's key role for zymocin-induced cell death in yeast. Mol Microbiol 16390459
Lecointe F Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop. J Biol Chem 9430663
Hager J Active site in RrmJ, a heat shock-induced methyltransferase. J Biol Chem 12181314
Mathevon C tRNA-modifying MiaE protein from Salmonella typhimurium is a nonheme diiron monooxygenase. Proc Natl Acad Sci U S A 17679698
Sirum-Connolly K Functional requirement of a site-specific ribose methylation in ribosomal RNA. Science 8266080
Hong B Temperature sensitive nop2 alleles defective in synthesis of 25S rRNA and large ribosomal subunits in Saccharomyces cerevisiae. Nucleic Acids Res 11452018
Sergiev PV Ribosomal RNA guanine-(N2)-methyltransferases and their targets. Nucleic Acids Res 17389639
Mao X Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene. Mol Cell Biol 7623811
Bujnicki JM mRNA:guanine-N7 cap methyltransferases: identification of novel members of the family, evolutionary analysis, homology modeling, and analysis of sequence-structure-function relationships. BMC Bioinformatics 11472630
Hagervall TG Reduced misreading of asparagine codons by Escherichia coli tRNALys with hypomodified derivatives of 5-methylaminomethyl-2-thiouridine in the wobble position. J Mol Biol 9811540
Monleon D Structural insights into the GTPase domain of Escherichia coli MnmE protein. Proteins 17143896
Nilsson K The cysteine desulfurase IscS is required for synthesis of all five thiolated nucleosides present in tRNA from Salmonella enterica serovar typhimurium. J Bacteriol 12446633
Hoang C Crystal structure of the highly divergent pseudouridine synthase TruD reveals a circular permutation of a conserved fold. RNA 15208439
Bujnicki JM Identification of a bifunctional enzyme MnmC involved in the biosynthesis of a hypermodified uridine in the wobble position of tRNA. RNA 15247431
White J Bud23 methylates G1575 of 18S rRNA and is required for efficient nuclear export of pre-40S subunits. Mol Cell Biol 18332120
Wrzesinski J A dual-specificity pseudouridine synthase: an Escherichia coli synthase purified and cloned on the basis of its specificity for psi 746 in 23S RNA is also specific for psi 32 in tRNA(phe). RNA 7493321
Lee TT Crystal structure of RumA, an iron-sulfur cluster containing E. coli ribosomal RNA 5-methyluridine methyltransferase. Structure 15016356
Henriquez R Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen. J Biol Chem 2298745
O'Farrell HC Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution. RNA 16540698
Waterman DG Crystal structure of Bacillus anthracis ThiI, a tRNA-modifying enzyme containing the predicted RNA-binding THUMP domain. J Mol Biol 16343540
Ansmant I Identification and characterization of the tRNA:Psi 31-synthase (Pus6p) of Saccharomyces cerevisiae. J Biol Chem 11406626
Liiv A Analysis of the function of E. coli 23S rRNA helix-loop 69 by mutagenesis. BMC Mol Biol 16053518
Martinez-Vicente M Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification. J Biol Chem 15983041
Guan MX Mutation in TRMU related to transfer RNA modification modulates the phenotypic expression of the deafness-associated mitochondrial 12S ribosomal RNA mutations. Am J Hum Genet 16826519
Rashid R Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Mol Cell 16427014
Sergiev PV Identification of Escherichia coli m2G methyltransferases: II. The ygjO gene encodes a methyltransferase specific for G1835 of the 23 S rRNA. J Mol Biol 17010380
Corollo D Crystallization and characterization of a fragment of pseudouridine synthase RluC from Escherichia coli. Acta Crystallogr D Biol Crystallogr 10089432
Roovers M The YqfN protein of Bacillus subtilis is the tRNA: m1A22 methyltransferase (TrmK). Nucleic Acids Res 18420655
Tkaczuk KL Molecular phylogenetics and comparative modeling of HEN1, a methyltransferase involved in plant microRNA biogenesis. BMC Evol Biol 16433904
Lafontaine DL The box H + ACA snoRNAs carry Cbf5p, the putative rRNA pseudouridine synthase. Genes Dev 9472021
Lovgren JM The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli. J Bacteriol 11698387
Nishimura K Identification of the RsmG methyltransferase target as 16S rRNA nucleotide G527 and characterization of Bacillus subtilis rsmG mutants. J Bacteriol 17573471
Kaya Y Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold. J Biol Chem 14999002
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