Modomics - A Database of RNA Modifications

Published on April 4, 2014 in Chem Commun (Camb). volume 50(26):3516-8.

PubMed ID: 24567952

DOI: 10.1039/c3cc49114e


The combination of (15)N/(13)C stable isotope labelling (SIL) and LC-MS/MS revealed a total of 52 modifications in RNA from E. coli and yeast, including 10 previously undescribed modifications. Two modifications, N-ribosylnicotinamide and 2-methylthioadenosine, were newly detected in species hitherto thought not to contain these modifications.