Modomics - A Database of RNA Modifications

Reaction details:

Reaction type level 1: methylation
Reaction type level 2: alkylation
Reaction type level 3: group addition
Input group: H
Output group: *C
Introduced group name: methyl
Introduced group type: hydrocarbon
Site: sugar
Atom address: 2′O
Modification level: 1

Enzymes that catalyse this reaction:

Acronym Full name Organism
CMTR1 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Homo sapiens
CMTr2 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 Homo sapiens
FBL rRNA 2′-O-methyltransferase fibrillarin Homo sapiens
Nop1 rRNA 2′-O-methyltransferase fibrillarin Saccharomyces cerevisiae
RlmM Ribosomal RNA large subunit methyltransferase M Escherichia coli
RsmI Ribosomal RNA small subunit methyltransferase I Escherichia coli
Trm13 tRNA-2′-O-methyltransferase TRM13 Saccharomyces cerevisiae
Trm7 tRNA (cytidine(32)/guanosine(34)-2′-O)-methyltransferase Saccharomyces cerevisiae
TrmJ tRNA (cytidine(32)/uridine(32)-2′-O)-methyltransferase Escherichia coli
TrmJ tRNA (cytidine(32)-2′-O)-methyltransferase Sulfolobus acidocaldarius
TrmL tRNA (cytidine(34)-2′-O)-methyltransferase Escherichia coli
aTrm56 tRNA (cytidine(56)-2'-O)-methyltransferase Pyrococcus abyssi

Image with reaction