ID Card:
| Full name: |
tRNA (guanine(9)-/adenine(9)-N1)-methyltransferas |
| UniProt: |
Q5JD38 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - m1A
t:None - m1G
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
MKTLADVFREALKEKGISSIGTLSKRFRKSKNKLQDIAIEIVHGKGAVFRVPEKTAVAWDLNGNRVDGSYYAYAPLCMREKFEPVLTPEELREKLPDWPYFIIDLYHWDKHTQKEKGKICLQVNQSYGLLRDYFTGSELAVTWANEEFREMFHGPLDRITTYGGPTSEFLKENGINEVVLLDPWAEEVLSEKDFDVKAFIIGGIVDTGGNKKKTTPKIGEELESAGIKVRRRKIVLRGDVVGVPDRINRILGIILKMMVEGKSMDEAVYEMQEPLHARWRLRKELPKRATRYMVEGKVYRVVEKELFDEYSKWLKIRWEDFVKVLRELDLVALERKRIHHLNKISNARIINGKLHRVILLKRAAMLCYNC
Comments:
Methylates the N1 -atom of either adenosine or guanosine at position 9 in different tRNAs.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
A:m1A
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
9 |
|
|
|
|
|
|
|
|
G:m1G
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
9 |
|
|
|
|
|
|
|
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA. |
Kempenaers M; Roovers M; Oudjama Y; Tkaczuk KL; Bujnicki JM; Droogmans L |
Nucleic Acids Res |
[details]
|
20525789
|
10.1093/nar/gkq451
|