Modomics - A Database of RNA Modifications

ID Card:

Full name: Mitochondrial tRNA-specific 2-thiouridylase 1
Synonym: MTU1, TRMT1
GI: 31542641
COG: COG0482
UniProt: O75648
Alpha Fold Predicted Structure: AF-O75648-F1
Enzyme type: sulfurtransferase
Position of modification - modification: t:34 - tm5s2U



Protein sequence:

MQALRHVVCALSGGVDSAVAALLLRRRGYQVTGVFMKNWDSLDEHGVCTADKDCEDAYRVCQILDIPFHQVSYVKEYWNDVFSDFLNEYEKGRTPNPDIVCNKHIKFSCFFHYAVDNLGADAIATGHYARTSLEDEEVFEQKHVKKPEGLFRNRFEVRNAVKLLQAADSFKDQTFFLSQVSQDALRRTIFPLGGLTKEFVKKIAAENRLHHVLQKKESMGMCFIGKRNFEHFLLQYLQPRPGHFISIEDNKVLGTHKGWFLYTLGQRANIGGLREPWYVVEKDSVKGDVFVAPRTDHPALYRDLLRTSRVHWIAEEPPAALVRDKMMECHFRFRHQMALVPCVLTLNQDGTVWVTAVQAVRALATGQFAVFYKGDECLGSGKILRLGPSAYTLQKGQRRAGMATESPSDSPEDGPGLSPLL

Comments:

Homolog of yeast mitochondrial ATP-dependent tRNA sulfurtransferase Mtu1. Sulfur group originates from cysteine via a cascade of sulphur relay proteins, including the pyridoxal phosphate-containing cysteine desulfurase Nfs1 and at least a third mitochondrial sulfur transport protein. In mitochondria of T. brucei (Eukarya), this third protein partner is Isd11.





Alpha Fold Predicted Structure:




Processing file... [389867/389867]


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Protein sequence:

M Q A L R H V V C A L S G G V D S A V A A L L L R R R G Y Q V T G V F M K N W D S L D E H G V C T A D K D C E D A Y R V C Q I L D I P F H Q V S Y V K E Y W N D V F S D F L N E Y E K G R T P N P D I V C N K H I K F S C F F H Y A V D N L G A D A I A T G H Y A R T S L E D E E V F E Q K H V K K P E G L F R N R F E V R N A V K L L Q A A D S F K D Q T F F L S Q V S Q D A L R R T I F P L G G L T K E F V K K I A A E N R L H H V L Q K K E S M G M C F I G K R N F E H F L L Q Y L Q P R P G H F I S I E D N K V L G T H K G W F L Y T L G Q R A N I G G L R E P W Y V V E K D S V K G D V F V A P R T D H P A L Y R D L L R T S R V H W I A E E P P A A L V R D K M M E C H F R F R H Q M A L V P C V L T L N Q D G T V W V T A V Q A V R A L A T G Q F A V F Y K G D E C L G S G K I L R L G P S A Y T L Q K G Q R R A G M A T E S P S D S P E D G P G L S P L L
50100150200250300350400SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-O75648-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-O75648-F1.cif  
DSSP Secondary Structures   O75648.dssp  





Publications:

Links:

_PubMed_