Modomics - A Database of RNA Modifications

Reaction details:

Reaction type level 1: O/S exchange
Reaction type level 2: O/S exchange
Reaction type level 3: group exchange
Input group: O
Output group: *=S
Introduced group name: thio
Introduced group type: sulphur
Site: base/endocyclic
Atom address: C2
Modification level: 4

Enzymes that catalyse this reaction:

Acronym Full name Organism
MnmA tRNA 2-thiouridine(34) synthase Escherichia coli
Mtu1 Mitochondrial tRNA-specific 2-thiouridylase 1 Saccharomyces cerevisiae
TrmU Mitochondrial tRNA-specific 2-thiouridylase 1 Homo sapiens

Image with reaction


Title Authors Journal Details PubMed Id DOI
MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. Kambampati R, Lauhon CT Biochemistry [details] 12549933 -