Modomics - A Database of RNA Modifications

ID Card:

Full name: tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial
GI: 222831587
COG: COG2519
UniProt: Q9BVS5
Structures: | 2B25 |
Alpha Fold Predicted Structure: AF-Q9BVS5-F1
Enzyme type: methyltransferase
Position of modification - modification: t:58 - m1A


PDB Structures:


2B25

Structure Description:

Title: Human putative tRNA(1-methyladenosine)methyltransferase
Classification: TRANSFERASE
Technique: X-Ray Diffraction
Resolution: 2.5
R value free: 0.282
R value observed:
R value work: 0.247

Abstract of the PDB Structure's related Publication:



Download RCSB-PDB Structures:

Pdb Files   2B25.pdb  
Pdbx/mmCIF Files   2B25.cif  


Protein sequence:

MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN

Comments:

Paralog of cytoplasmic Trm61A. Unlike its cytoplasmic paralog that consists of an alpha2beta2 heterotetramer formed by Trmt61A and Trmt6, Trmt61B forms a homo-oligomer (presumably a homotetramer).





Alpha Fold Predicted Structure:




Parsing response... [428068/428068]


Clear Selection and Reset Camera

Protein sequence:

M L M A W C R G P V L L C L R Q G L G T N S F L H G L G Q E P F E G A R S L C C R S S P R D L R D G E R E H E A A Q R K A P G A E S C P S L P L S I S D I G T G C L S S L E N L R L P T L R E E S S P R E L E D S S G D Q G R C G P T H Q G S E D P S M L S Q A Q S A T E V E E R H V S P S C S T S R E R P F Q A G E L I L A E T G E G E T K F K K L F R L N N F G L L N S N W G A V P F G K I V G K F P G Q I L R S S F G K Q Y M L R R P A L E D Y V V L M K R G T A I T F P K D I N M I L S M M D I N P G D T V L E A G S G S G G M S L F L S K A V G S Q G R V I S F E V R K D H H D L A K K N Y K H W R D S W K L S H V E E W P D N V D F I H K D I S G A T E D I K S L T F D A V A L D M L N P H V T L P V F Y P H L K H G G V C A V Y V V N I T Q V I E L L D G I R T C E L A L S C E K I S E V I V R D W L V C L A K Q K N G I L A Q K V E S K I N T D V Q L D S Q E K I G V K G E L F Q E D D H E E S H S D F P Y G S F P Y V A R P V H W Q P G H T A F L V K L R K V K P Q L N
50100150200250300350400450SequenceGHTBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9BVS5-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9BVS5-F1.cif  
DSSP Secondary Structures   Q9BVS5.dssp  





Diseases connected to this enzyme:

Publications:

Links:

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