| Name | Myoclonus epilepsy, ragged-red fibers (MERRF) (A:m1A) |
| Description | Missing m1A modification on mitochondrial tRNA at the 58 position is associated with the MERRF disease. m1A58 provides a positive charge on tRNA tertiary structure that affect the binding of elongation factor which delivers tRNA to ribosome. |
| Related RNA reaction | A:m1A |
| Found in RNA | mt-tRNA |
| Modified Transcript | |
| Mapping Technology | DM-tRNA-seq , tRNA-seq |
| Quantification techniques | Semi-quantitative RT-PCR |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| Trmt61B | tRNA (adenine(58)-N(1))-methyltransferase, mitochondrial | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1082 | RNA modification landscape of the human mitochondrial tRNA regulates protein synthesis. | Uwe Richter | Nat Commun | [details] | 30262910 | 10.1038/s41467-018-06471-z |