Modomics - A Database of RNA Modifications

ID Card:

Full name: Mitochondrial tRNA-specific 2-thiouridylase 1
Synonym: Mto2, SLM3
GI: 6320172
Orf: D2761
COG: COG0482
UniProt: Q12093
Structures: | |
Alpha Fold Predicted Structure: AF-Q12093-F1
Enzyme type: sulfurtransferase
Position of modification - modification: t:34 - cmnm5s2U



Protein sequence:

MLARYLNLIGRRSASPYRPQRLPAKFDNVIVAMSSGVDSSVAAALFAGEFPNTRGVYMQNWSESQSLDDPGKEPCYERDWRDVNRVAKHLNIRVDKVNFEQDYWIDVFEPMLRGYSEGSTPNPDIGCNKFVKFGKLREWLDEKYGTGNYWLVTGHYARVMQEMNGKGLFHLLRSIYRPKDQSYYLSQINSTVLSSLLLPIGHLTKPEVRDLAKYAGLPTAEKPDSQGICFVNNSQHGKFKNFLKHYLPSSPGDIITVDPQSGAKTTWGRHDGLWSYTIGQKVGISMPQADPNYQGTWFVSEKLRDTNEILIVRGRDNPALYSDTMRIENFSSLGPREDTINAFQNTGALTLQFRSLQVPVQIKSCKLNRSADNLDITIHLASKQRAITPGQSCCLYIDDRVLGSGPISHVNNNDTHA

Comments:

Homolog of bacterial ATP-dependent tRNA sulphur transferase MnmA (alias TrmU). Sulfur group originates from cysteine via a cascade of sulphur relay proteins, of which the pyridoxal phosphate-containing cysteine desulfurase Nfs1 plays the same role as IscS in bacteria. At least one other mitochondrial sulfur transport protein remains to be identified (2012). U34 thiolation in mitochondria differs from that in bacteria, which involves IscS (instead of Nfs1) and a cascade of relay proteins TusA,B,C,D,E.





Alpha Fold Predicted Structure:




Parsing response... [385086/385086]


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Protein sequence:

M L A R Y L N L I G R R S A S P Y R P Q R L P A K F D N V I V A M S S G V D S S V A A A L F A G E F P N T R G V Y M Q N W S E S Q S L D D P G K E P C Y E R D W R D V N R V A K H L N I R V D K V N F E Q D Y W I D V F E P M L R G Y S E G S T P N P D I G C N K F V K F G K L R E W L D E K Y G T G N Y W L V T G H Y A R V M Q E M N G K G L F H L L R S I Y R P K D Q S Y Y L S Q I N S T V L S S L L L P I G H L T K P E V R D L A K Y A G L P T A E K P D S Q G I C F V N N S Q H G K F K N F L K H Y L P S S P G D I I T V D P Q S G A K T T W G R H D G L W S Y T I G Q K V G I S M P Q A D P N Y Q G T W F V S E K L R D T N E I L I V R G R D N P A L Y S D T M R I E N F S S L G P R E D T I N A F Q N T G A L T L Q F R S L Q V P V Q I K S C K L N R S A D N L D I T I H L A S K Q R A I T P G Q S C C L Y I D D R V L G S G P I S H V N N N D T H A
50100150200250300350400SequenceGHITBSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q12093-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q12093-F1.cif  
DSSP Secondary Structures   Q12093.dssp  





Publications:

Links:

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