General Data

RNA Type	unknown
Original Source	Sci-ModoM
Transcript ID:	ENST00000527328
Gene ID:	ENSG00000185122
Gene Name:	HSF1
Sequence (UNICHARACTER ENCODING)	UGAGGCAAGCCCACCUCGGAAGGCCAGCUCAGGUCUCACGUCCACUUUGGGGCUCCAGGCAUGCGGGAACCCCAAUGCCAGUACGGCUUCCUCGGCUCCGUGCAGCAGGCGCUCUUGACCCCCACGUCAUGGAGGAGGCCUUGGCCUCAGACUCUCCUGCAUGGGGUCUAGCAGGAGCCACCGGCUUUGUGAUUCCUGGAGUCCGGCCACGUGGЖCCUGGCCUACCAAGAAGACUCACAGGCUUGACAGGGCCCAGCCUCCCAGAGCAGCAGGAGCGCGGUCAUGGCCCUGCUCACCUGGCUGGGGЖCAGCUCUUCCCCACCCCUGAGCCACCUCCAGGCCUGGCGAGGGCCCUGAGCACCUACAGGЖCAUGGGЖCAGCCAGUGUCGCAGCCUGAAGAACCGUCCUCCCUUAACCUGGCUGCUCAGGCCUUGGAAGGGCGGCCCAAGGGUCUGCUCCUGGCCUGUGUCCAAGGCAGCCCUCCAGGUGUUUGCCAGGAUGGAUGCCAGGAUCCGGGUGCACCUGGCUCGCAUGGAUCCAUCCCCAACACCCUACGUGACACCAGGUGUCCCCGGCAGGGAGGGGCAGUGGGACCAGCAAGCCCUGGCCCUGGCCCCCAGUCCCUCCACACACAAGUUCUCAUCCUGGGGUGGGCCAGGCCAGACAUGGUCACACUUACCCCUGCUCCUGCAUGGGGGACAGGGAGGGUCUGUGGGGCUCCCUCAGCCCUGGGGCUCAUGGGAUUGGGCCCCACUGACCCAGCCUGGUCUGUUGCAGUGAGAAUGAGGCUCUGUGGCGGGAGGUGGCCAGCCUUCGGCAGAAGCAUGCCCAGCAACAGAAAGUCGUCAACAAGCUCAUUCAGUUCCUGAUCUCACUGGUGCAGUCAAЖCCGGAUCCUGGGGGUGAAGAGAAAGAUCCCCCUGAUGCUGAACGACAGUGGCUCAGCACAUUCCAUGCCCAAGUAUAGCCGGCAGUUCUCCCUGGAGCACGUCCACGGCUCGGGCCCCUACUCGGCCCCCUCCCCAGCCUACAGCAGCUCCAGCCUCUACGCCCCUGAUGCUGUGGCCAGCUCUGGACCCAUCAUCUCCGACAUCACCGAGCUGGCUCCUGCCAGCCCCAUGGCCUCCCCCGGCGGGAGCAUAGACGAGAGGCCCCUAUCCAGCAGCCCCCUGGUGCGUGUCAAGGAGGAGCCCCCCAGCCCGCCUCAGAGCCCCCGGGUAGAGGAGGCGAGUCCCGGGCGCCCAUCUUCCGUGGACACCCUCUUGUCCCCGACCGCCCUCAUUGACUCCAPCCUGCGGGAGAGUGAЖCCUGCCCCCGCCPCCGUCACAGCCCUCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCUCCCUCCCCCCCGCCCACCUCCACCCCUGAAAAGUGCCUCAGCGUAGCCUGCCUGGЖCAAGAAUGAGCUCAGUGACCACUUGGAUGCUAUGGACUCCAACCUGGAUAACCUGCAGACCAUGCUGAGCAGCCACGGCUUCAGCGUGGACACCAGUGCCCUGCUGGACCUGUUCAGCCCCUCGGUGACCGUGCCCGACAUGAGCCUGCCUGACCUUGACAGCAGCCUGGCCAGUGUGCGUAGGCGGGCGGGGGGUGAGGGGGAACGAGACCAGCGGGAGUGCUCACAAUACCGUCUCCACCCCACAGAUCCAAGAGCUCCUGUCUCCCCAGGAGCCCCCCAGGCCUCCCGAGGCAGAGAЖCAGCAGCCCGGAUUCAGGGAAGCAGCUGGUGCACUACЖCAGCGCAGCCGCUGUUCCUGCUGGACCCCGGCUCCGUGGACACCGGGAGCAACGACCUGCCGGUGCUGUUUGAGCUGGGAGAGGGCUCCUACUUCUCCGAAGGGGACGGCUUCGCCGAGGACCCCACCAUCUCCCUGCUGACAGGCUCGGAGCCUCCCAAAGCCAAGGACCCCACUGUCUCCUAGAGGCCCCGGAGGAGCUGGGCCAGCCGCCCACCCCCACCCCCAGUGCAGGGCUGGUCUUGGGGAGGCAGGGCAGCCUCGCGGUCUUGGGCACUGGUGGGUCGGCCGCCAUAGCCCCAGUAGGЖCAAACGGGCUCGGGUCUGGGCAGCЖCCUCUGGUCAGGAGGGUCACCCUGGCCUGCCAGUCUGCCUUCCCCCAACCCCGUGUCCUGUGGUUUGGUUGGGGCUUCACAGCCACACCUGGЖCUGACCCUGCAGGUUGUUCAUAGUCAGAAUUGUAUUUUGGAUUUUUACACAACUGUCCCGUUCCCCGCUCCACAGAGAUACACAGAUAUAUACACACAGUGGAUGGACGGACAAGACAGGCAGAGAUCUAUAAЖCAGACAGGCUCU
Sequence (SHORT NAMES ENCODING)	UGAGGCAAGCCCACCUCGGAAGGCCAGCUCAGGUCUCACGUCCACUUUGGGGCUCCAGGCAUGCGGGAACCCCAAUGCCAGUACGGCUUCCUCGGCUCCGUGCAGCAGGCGCUCUUGACCCCCACGUCAUGGAGGAGGCCUUGGCCUCAGACUCUCCUGCAUGGGGUCUAGCAGGAGCCACCGGCUUUGUGAUUCCUGGAGUCCGGCCACGUGGm6ACCUGGCCUACCAAGAAGACUCACAGGCUUGACAGGGCCCAGCCUCCCAGAGCAGCAGGAGCGCGGUCAUGGCCCUGCUCACCUGGCUGGGGm6ACAGCUCUUCCCCACCCCUGAGCCACCUCCAGGCCUGGCGAGGGCCCUGAGCACCUACAGGm6ACAUGGGm6ACAGCCAGUGUCGCAGCCUGAAGAACCGUCCUCCCUUAACCUGGCUGCUCAGGCCUUGGAAGGGCGGCCCAAGGGUCUGCUCCUGGCCUGUGUCCAAGGCAGCCCUCCAGGUGUUUGCCAGGAUGGAUGCCAGGAUCCGGGUGCACCUGGCUCGCAUGGAUCCAUCCCCAACACCCUACGUGACACCAGGUGUCCCCGGCAGGGAGGGGCAGUGGGACCAGCAAGCCCUGGCCCUGGCCCCCAGUCCCUCCACACACAAGUUCUCAUCCUGGGGUGGGCCAGGCCAGACAUGGUCACACUUACCCCUGCUCCUGCAUGGGGGACAGGGAGGGUCUGUGGGGCUCCCUCAGCCCUGGGGCUCAUGGGAUUGGGCCCCACUGACCCAGCCUGGUCUGUUGCAGUGAGAAUGAGGCUCUGUGGCGGGAGGUGGCCAGCCUUCGGCAGAAGCAUGCCCAGCAACAGAAAGUCGUCAACAAGCUCAUUCAGUUCCUGAUCUCACUGGUGCAGUCAAm6ACCGGAUCCUGGGGGUGAAGAGAAAGAUCCCCCUGAUGCUGAACGACAGUGGCUCAGCACAUUCCAUGCCCAAGUAUAGCCGGCAGUUCUCCCUGGAGCACGUCCACGGCUCGGGCCCCUACUCGGCCCCCUCCCCAGCCUACAGCAGCUCCAGCCUCUACGCCCCUGAUGCUGUGGCCAGCUCUGGACCCAUCAUCUCCGACAUCACCGAGCUGGCUCCUGCCAGCCCCAUGGCCUCCCCCGGCGGGAGCAUAGACGAGAGGCCCCUAUCCAGCAGCCCCCUGGUGCGUGUCAAGGAGGAGCCCCCCAGCCCGCCUCAGAGCCCCCGGGUAGAGGAGGCGAGUCCCGGGCGCCCAUCUUCCGUGGACACCCUCUUGUCCCCGACCGCCCUCAUUGACUCCAYCCUGCGGGAGAGUGAm6ACCUGCCCCCGCCYCCGUCACAGCCCUCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCUCCCUCCCCCCCGCCCACCUCCACCCCUGAAAAGUGCCUCAGCGUAGCCUGCCUGGm6ACAAGAAUGAGCUCAGUGACCACUUGGAUGCUAUGGACUCCAACCUGGAUAACCUGCAGACCAUGCUGAGCAGCCACGGCUUCAGCGUGGACACCAGUGCCCUGCUGGACCUGUUCAGCCCCUCGGUGACCGUGCCCGACAUGAGCCUGCCUGACCUUGACAGCAGCCUGGCCAGUGUGCGUAGGCGGGCGGGGGGUGAGGGGGAACGAGACCAGCGGGAGUGCUCACAAUACCGUCUCCACCCCACAGAUCCAAGAGCUCCUGUCUCCCCAGGAGCCCCCCAGGCCUCCCGAGGCAGAGAm6ACAGCAGCCCGGAUUCAGGGAAGCAGCUGGUGCACUACm6ACAGCGCAGCCGCUGUUCCUGCUGGACCCCGGCUCCGUGGACACCGGGAGCAACGACCUGCCGGUGCUGUUUGAGCUGGGAGAGGGCUCCUACUUCUCCGAAGGGGACGGCUUCGCCGAGGACCCCACCAUCUCCCUGCUGACAGGCUCGGAGCCUCCCAAAGCCAAGGACCCCACUGUCUCCUAGAGGCCCCGGAGGAGCUGGGCCAGCCGCCCACCCCCACCCCCAGUGCAGGGCUGGUCUUGGGGAGGCAGGGCAGCCUCGCGGUCUUGGGCACUGGUGGGUCGGCCGCCAUAGCCCCAGUAGGm6ACAAACGGGCUCGGGUCUGGGCAGCm6ACCUCUGGUCAGGAGGGUCACCCUGGCCUGCCAGUCUGCCUUCCCCCAACCCCGUGUCCUGUGGUUUGGUUGGGGCUUCACAGCCACACCUGGm6ACUGACCCUGCAGGUUGUUCAUAGUCAGAAUUGUAUUUUGGAUUUUUACACAACUGUCCCGUUCCCCGCUCCACAGAGAUACACAGAUAUAUACACACAGUGGAUGGACGGACAAGACAGGCAGAGAUCUAUAAm6ACAGACAGGCUCU
Sequence (MODOMICS CODE ENCODING)	UGAGGCAAGCCCACCUCGGAAGGCCAGCUCAGGUCUCACGUCCACUUUGGGGCUCCAGGCAUGCGGGAACCCCAAUGCCAGUACGGCUUCCUCGGCUCCGUGCAGCAGGCGCUCUUGACCCCCACGUCAUGGAGGAGGCCUUGGCCUCAGACUCUCCUGCAUGGGGUCUAGCAGGAGCCACCGGCUUUGUGAUUCCUGGAGUCCGGCCACGUGG2000000006ACCUGGCCUACCAAGAAGACUCACAGGCUUGACAGGGCCCAGCCUCCCAGAGCAGCAGGAGCGCGGUCAUGGCCCUGCUCACCUGGCUGGGG2000000006ACAGCUCUUCCCCACCCCUGAGCCACCUCCAGGCCUGGCGAGGGCCCUGAGCACCUACAGG2000000006ACAUGGG2000000006ACAGCCAGUGUCGCAGCCUGAAGAACCGUCCUCCCUUAACCUGGCUGCUCAGGCCUUGGAAGGGCGGCCCAAGGGUCUGCUCCUGGCCUGUGUCCAAGGCAGCCCUCCAGGUGUUUGCCAGGAUGGAUGCCAGGAUCCGGGUGCACCUGGCUCGCAUGGAUCCAUCCCCAACACCCUACGUGACACCAGGUGUCCCCGGCAGGGAGGGGCAGUGGGACCAGCAAGCCCUGGCCCUGGCCCCCAGUCCCUCCACACACAAGUUCUCAUCCUGGGGUGGGCCAGGCCAGACAUGGUCACACUUACCCCUGCUCCUGCAUGGGGGACAGGGAGGGUCUGUGGGGCUCCCUCAGCCCUGGGGCUCAUGGGAUUGGGCCCCACUGACCCAGCCUGGUCUGUUGCAGUGAGAAUGAGGCUCUGUGGCGGGAGGUGGCCAGCCUUCGGCAGAAGCAUGCCCAGCAACAGAAAGUCGUCAACAAGCUCAUUCAGUUCCUGAUCUCACUGGUGCAGUCAA2000000006ACCGGAUCCUGGGGGUGAAGAGAAAGAUCCCCCUGAUGCUGAACGACAGUGGCUCAGCACAUUCCAUGCCCAAGUAUAGCCGGCAGUUCUCCCUGGAGCACGUCCACGGCUCGGGCCCCUACUCGGCCCCCUCCCCAGCCUACAGCAGCUCCAGCCUCUACGCCCCUGAUGCUGUGGCCAGCUCUGGACCCAUCAUCUCCGACAUCACCGAGCUGGCUCCUGCCAGCCCCAUGGCCUCCCCCGGCGGGAGCAUAGACGAGAGGCCCCUAUCCAGCAGCCCCCUGGUGCGUGUCAAGGAGGAGCCCCCCAGCCCGCCUCAGAGCCCCCGGGUAGAGGAGGCGAGUCCCGGGCGCCCAUCUUCCGUGGACACCCUCUUGUCCCCGACCGCCCUCAUUGACUCCA2000000009UCCUGCGGGAGAGUGA2000000006ACCUGCCCCCGCC2000000009UCCGUCACAGCCCUCACGGACGCCAGGGGCCACACGGACACCGAGGGCCGGCCUCCCUCCCCCCCGCCCACCUCCACCCCUGAAAAGUGCCUCAGCGUAGCCUGCCUGG2000000006ACAAGAAUGAGCUCAGUGACCACUUGGAUGCUAUGGACUCCAACCUGGAUAACCUGCAGACCAUGCUGAGCAGCCACGGCUUCAGCGUGGACACCAGUGCCCUGCUGGACCUGUUCAGCCCCUCGGUGACCGUGCCCGACAUGAGCCUGCCUGACCUUGACAGCAGCCUGGCCAGUGUGCGUAGGCGGGCGGGGGGUGAGGGGGAACGAGACCAGCGGGAGUGCUCACAAUACCGUCUCCACCCCACAGAUCCAAGAGCUCCUGUCUCCCCAGGAGCCCCCCAGGCCUCCCGAGGCAGAGA2000000006ACAGCAGCCCGGAUUCAGGGAAGCAGCUGGUGCACUAC2000000006ACAGCGCAGCCGCUGUUCCUGCUGGACCCCGGCUCCGUGGACACCGGGAGCAACGACCUGCCGGUGCUGUUUGAGCUGGGAGAGGGCUCCUACUUCUCCGAAGGGGACGGCUUCGCCGAGGACCCCACCAUCUCCCUGCUGACAGGCUCGGAGCCUCCCAAAGCCAAGGACCCCACUGUCUCCUAGAGGCCCCGGAGGAGCUGGGCCAGCCGCCCACCCCCACCCCCAGUGCAGGGCUGGUCUUGGGGAGGCAGGGCAGCCUCGCGGUCUUGGGCACUGGUGGGUCGGCCGCCAUAGCCCCAGUAGG2000000006ACAAACGGGCUCGGGUCUGGGCAGC2000000006ACCUCUGGUCAGGAGGGUCACCCUGGCCUGCCAGUCUGCCUUCCCCCAACCCCGUGUCCUGUGGUUUGGUUGGGGCUUCACAGCCACACCUGG2000000006ACUGACCCUGCAGGUUGUUCAUAGUCAGAAUUGUAUUUUGGAUUUUUACACAACUGUCCCGUUCCCCGCUCCACAGAGAUACACAGAUAUAUACACACAGUGGAUGGACGGACAAGACAGGCAGAGAUCUAUAA2000000006ACAGACAGGCUCU

Score Table

_{Table containing the score explanation. Score identify the level of experimental reliability and evidence so as exaplained in the 2023 release manuscript. Class 1 should be considered as highlyrelevant. Class 2 evidences are considered as Solid, namely large errors are unlikely and minor errors should not undermine the meaning of data. Class 3 is considered as speculative and errors are expected. Class 4 is considered as questionable. Class 5 evidence means that verification and data are still to be collected. Class 6 data cannot be estimated.}

Method Classification	Score
Multiple direct experimental evidence	1
Direct experimental evidence	2
Inferred based on indirect experimental evidence	3
Predicted computationally	4
Evidence not yet annotated (Unknown)	5
Irrelevant	6

Modification Positions

_{Table containing the original modifications present in the MODOMICS sequences. Edit locations not originally present in the RNA sequences are marked by their source. Their scores are in third row.}

Position in the Sequence	215	307	368	375	886	1288	1304	1317	1426	1727	1765	2072	2097	2190	2324
Modification Positions	m6A	m6A	m6A	m6A	m6A	Y	m6A	Y	m6A	m6A	m6A	m6A	m6A	m6A	m6A
Genomic Coordinates	8:144310613:+	8:144310705:+	8:144310766:+	8:144310773:+	8:144311355:+	8:144312103:+	8:144312119:+	8:144312132:+	8:144312241:+	8:144314037:+	8:144314145:+	8:144314452:+	8:144314477:+	8:144314570:+	8:144314704:+
Level of Experimental Evidence	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
Level of Experimental Reliability	3	3	3	3	3	3	3	3	3	3	3	3	3	3	3
Source	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM	Sci-ModoM
EUFIDs	6UuHp6YApVKv gZuvgwMuBfgh jNkxUQNx8GRd msuJfBpJvM5H VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn	6UuHp6YApVKv gBgcfFQ5WN9C gZuvgwMuBfgh jNkxUQNx8GRd Mg9GixDBFQAT msuJfBpJvM5H Q36pf44ZRvxu UN3tNpbCPHYf VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn	6UuHp6YApVKv jNkxUQNx8GRd msuJfBpJvM5H VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn	6UuHp6YApVKv jNkxUQNx8GRd msuJfBpJvM5H Q36pf44ZRvxu VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	NjZ8bGGJsNSR 8cMbzB4aD5Se 834aFpha8RvT dA7YoLwHrzgR JASnTTw2HeNE ksEP666umrV9 NKGM8wdLLrnu ZuM5xpZmNuDL BtsJQJ3DteUq bXBqJigD9oV3 dknfVe6BK8aP f6YSioLdAWpr iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 CxQaH6qDB9bC dknfVe6BK8aP eGNFqdoGxzRm f6YSioLdAWpr Mk6ShCGm6RBJ iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	3kRDPWwiRCgi L6w2k2VEv4EY	3TeAZFYFxgvp 4HMi5ykupT9V 5aTkEfEpX8Xm 5FhTyQVy2tKW 6AyXsheySjfx 6UuHp6YApVKv aHkqKEJkRYyb aivdrAsbdKEU Ap2q43bQLNek gZuvgwMuBfgh jNkxUQNx8GRd msuJfBpJvM5H NjZ8bGGJsNSR Q36pf44ZRvxu QmcpiJ88DBDn QpiKdbVikVz2 UN3tNpbCPHYf VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn aJksAshEgQ8U D6ncpa2PPWj3 nfCHyrYzE6fB Lny8GcCeVGc9 UKen6WEino9G BtsJQJ3DteUq bXBqJigD9oV3 CxQaH6qDB9bC dknfVe6BK8aP eGNFqdoGxzRm f6YSioLdAWpr kx7BHU7ZycYE Mk6ShCGm6RBJ XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	834aFpha8RvT dA7YoLwHrzgR JASnTTw2HeNE ksEP666umrV9 NKGM8wdLLrnu ZuM5xpZmNuDL	3TeAZFYFxgvp 4HMi5ykupT9V 5aTkEfEpX8Xm 5FhTyQVy2tKW 5Nnepx5V7yHo 6AyXsheySjfx 6UuHp6YApVKv aHkqKEJkRYyb aivdrAsbdKEU Ap2q43bQLNek gBgcfFQ5WN9C gZuvgwMuBfgh jNkxUQNx8GRd KRfQJWH4K5KH Mg9GixDBFQAT msuJfBpJvM5H nGifePrmgHfe NjZ8bGGJsNSR Q36pf44ZRvxu QmcpiJ88DBDn QpiKdbVikVz2 UN3tNpbCPHYf V5PvfiKsgFMd VL7zkHvkfkoB VyCX26p5UBRL WdHxkJGRmFxn aJksAshEgQ8U 8cMbzB4aD5Se 93arJtwJmuS9 ArijeGVTwYBw WiQcrNTGZHPT BsCW7emuRX7M KENzb7mwdBd9 KjeH7Nsffuas Lny8GcCeVGc9 LZJKems7W2wi PF5iqBNSbHaa UKen6WEino9G XUkp6ghERQML 834aFpha8RvT dA7YoLwHrzgR JASnTTw2HeNE ksEP666umrV9 NKGM8wdLLrnu ZuM5xpZmNuDL BtsJQJ3DteUq bXBqJigD9oV3 CxQaH6qDB9bC dknfVe6BK8aP eGNFqdoGxzRm f6YSioLdAWpr kx7BHU7ZycYE Mk6ShCGm6RBJ oZ9Kp5NX8Hv5 XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8	BtsJQJ3DteUq bXBqJigD9oV3 CxQaH6qDB9bC dknfVe6BK8aP eGNFqdoGxzRm f6YSioLdAWpr kx7BHU7ZycYE Mk6ShCGm6RBJ XWZVGdLC6gGJ iezFbUdmY3A6 S9vNeQQYrhac JkWoGWVwjNda a7o5Kmjr4Tdp Yfn77uLS5tv8