Published on Aug. 1, 2025 in Imeta volume 4 (4).
PubMed ID: 40860432
DOI: 10.1002/imt2.70055
Abstract:
METTL5 catalyzes the <i>N</i> <sup>6</sup>-methyladenosine (m<sup>6</sup>A) methylation at A<sub>1771</sub> in 18S rRNA, a modification essential for its association with the ribosomal protein RPL24A, facilitating the assembly of 80S ribosome. This facilitates the translation of mRNAs encoding the detoxifying glutathione S-transferase (GST) enzymes, thereby maintaining normal reactive oxygen species (ROS) levels and ensuring proper abscisic acid (ABA) responses. In <i>mettl5</i> mutants, the absence of m<sup>6</sup>A<sub>1771</sub> compromises RPL24A incorporation and ribosome assembly, impairing the translation of GSTs. This results in ROS excessive accumulation and hypersensitivity to ABA.