Published on None in volume None.

PubMed ID: 31472957

DOI: 10.1016/j.bbrc.2019.08.107

Abstract:

N 6 -methyladenosine (m 6 A) "readers" play an important role in mRNA functions and metabolism. YTHDC2, as one of the m 6 A readers, controls fertileness through decreasing associated mRNA abundance and enhancing the translation efficiency of related mRNA via binding the targeted m 6 A RNA. However, how YTH domain of YTHDC2 recognize m 6 A RNA is still unknown. In this study, we determined the crystal structure of human YTHDC2 YTH domain, which adopts similar architecture to other solved YTH domain structures. YTHDC2 contains a conserved m 6 A binding pocket, and similar RNA binding surface shared by YTHDC1.