ID Card:
| Full name: |
tRNA pseudouridine synthase 3 |
| Synonym: |
HVO_1852 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - Y
|
| Level of experimental evidence: |
3 |
| Level of experimental reliability: |
2 |
Protein sequence:
Comments:
Haloferax volcanii Pus3, a homolog of bacterial TruA and yeast Pus3, is responsible for the pseudouridylation of position 39 (Ψ39) in tRNAs. Based on known activities of E. coli TruA and S. cerevisiae Pus3, it is also likely that this homolog catalyzes Ψ38, although this has not been directly confirmed in H. volcanii. Pus3 is not essential in H. volcanii, as viable deletion strains can be obtained.
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
U:Y
|
tRNA (t) |
tRNA/tRNA/prokaryotic cytosol |
39 |
|
|
|
|
|
|
|
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Pseudouridine formation in archaeal RNAs: The case of Haloferax volcanii. |
Blaby IK, Majumder M, Chatterjee K, Jana S, Grosjean H, de Crecy-Lagard V, Gupta R |
RNA |
[details]
|
21628430
|
-
|