| Full name: | tRNA (uracil(54)-C(5))-methyltransferase homolog |
|---|---|
| Synonym: | TRM2 homolog |
| UniProt: | Q8BQJ6 |
| Enzyme type: | |
| Position of modification - modification: |
t:None - m5U :425(None) - m5U |
| Level of experimental evidence: | 2 |
| Level of experimental reliability: | 2 |
MHNPRLFLSRAGFFSKPGLLPWDTGRPPDLSQSLLGRAYKGSFTSVIAKKHPSRQKYQKKQRHCRDDSWQERLADVVTPLWRLSYEAQLKVKFEAQKKLLQSLESHLKVLHGVSDTVAAHQSEGLRCLLHPIIPSPTTTGYRNKSTFSVYRSPDGNPKTVGYYLGTWKDGNVVCLPCNHLKNIPEKHSQVAQYYEVFLRQSSVEPCLLFHEGGHWRELVVRTNRQGHTMAIVTFHPQGLSEEEVCVQKVTLKDFFTKGPGAICELTSLYFQESTMTRCSHQQSPYQLLFGEPHIFEDLLGLKIRISPDAFFQINTAGAEMLYRIIGELSGVNSESLLLDICCGTGVIGLSVAQRASQVHGIELVEQAVEDARWTAAFNGVTNCEFHAGRAETILPQLLKSQKDEKLTVAVVNPARAGLHYRVVRAIRNCRTIHTLVFVSCKPHGESTRNFIELCCPPNSAKQLLGDPFVLREAVPVDLFPHTPHCELVLLFTR
TRMT2B is responsible for both tRNA and rRNA m5U-methylation in human mitochondria. TRMT2B is not essential for viability in human cells. Knoc-out of the TRMT2B gene shows no obvious phenotype with regards to RNA stability, mitochondrial translation, or cellular growth.
| Reaction | Substrate | SubstrateType | Position | (Anti)Codon | Modified (Anti)Codon | Amino Acid Change | Transcript Name | Transcript Region | Cellular Localization | References |
|---|---|---|---|---|---|---|---|---|---|---|
| U:m5U | tRNA (t) | tRNA/tRNA/eukaryotic mitochondrial | 54 | |||||||
| U:m5U | rRNA (r) | rRNA/rRNA/eukaryotic mitochondria | 425 |
| Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|
| Mouse Trmt2B protein is a dual specific mitochondrial metyltransferase responsible for mU formation in both tRNA and rRNA. | Ivan Laptev,Ekaterina Shvetsova,Sergey Levitskii,Marina Serebryakova,Maria Rubtsova,Alexey Bogdanov,Piotr Kamenski,Petr Sergiev,Olga Dontsova | RNA Biol | [details] | 31736397 | - |