ID Card:
| Full name: |
tRNA (guanine(10)-N(2))-methyltransferase |
| Synonym: |
TRMT11 |
| UniProt: |
Q7Z4G4 |
| Complex: |
TRM11 - TRM112 |
| Enzyme type: |
|
| Position of modification - modification: |
t:None - m2G
|
| Level of experimental evidence: |
2 |
| Level of experimental reliability: |
2 |
Protein sequence:
MALSCTLNRYLLLMAQEHLEFRLPEIKSLLLLFGGQFASSQETYGKSPFWILSIPSEDIARNLMKRTVCAKSIFELWGHGQSPEELYSSLKNYPVEKMVPFLHSDSTYKIKIHTFNKTLTQEEKIKRIDALEFLPFEGKVNLKKPQHVFSVLEDYGLDPNCIPENPHNIYFGRWIADGQRELIESYSVKKRHFIGNTSMDAGLSFIMANHGKVKENDIVFDPFVGTGGLLIACAHFGAYVYGTDIDYNTVHGLGKATRKNQKWRGPDENIRANLRQYGLEKYYLDVLVSDASKPSWRKGTYFDAIITDPPYGIRESTRRTGSQKEIPKGIEKWEKCPESHVPVSLSYHLSDMFLDLLNFAAETLVLGGRLVYWLPVYTPEYTEEMVPWHPCLELVSNCEQKLSSHTSRRLITMEKVKKFENRDQYSHLLSDHFLPYQGHNSFREKYFSGVTKRIAKEEKSTQE
Comments:
Catalytic subunit of the TRMT11-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N2-methylation of guanosine nucleotide at position 10 (m2G10) in tRNAs
| Reaction |
Substrate |
SubstrateType |
Position |
(Anti)Codon |
Modified (Anti)Codon |
Amino Acid Change |
Transcript Name |
Transcript Region |
Cellular Localization |
References |
|
G:m2G
|
tRNA (t) |
tRNA/tRNA/eukaryotic cytosol |
10 |
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Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| N 2-methylguanosine modifications on human tRNAs and snRNA U6 are important for cell proliferation, protein translation and pre-mRNA splicing. |
Wang C; Ulryck N; Herzel L; Pythoud N; Kleiber N; Guérineau V; Jactel V; Moritz C; Bohnsack MT; Carapito C; Touboul D; Bohnsack KE; Graille M |
Nucleic Acids Res |
[details]
|
37283053
|
10.1093/nar/gkad487
|