ID Card:
| Full name: |
RNA-directed RNA polymerase NS5 |
| UniProt: |
Q5WPU5 |
| Enzyme type: |
methyltransferase |
Protein sequence:
GRPGGRTLGEQWKEKLNGLSKEDFLKYRKEAITEVDRSAARKARRDGNKTGGHPVSRGSAKLRWMVERQFVKPIGKVVDLGCGRGGWSYYAATLKGVQEVRGYTKGGPGHEEPMLMQSYGWNLVTMKSGVDVYYKPSEPCDTLFCDIGESSSSAEVEEQRTLRILEMVSDWLQRGPREFCIKVLCPYMPRVMERLEVLQRRYGGGLVRVPLSRNSNHEMYWVSGAAGNIVHAVNMTSQVLIGRMEKRTWHGPKYEEDVNLGSGTRAVGKPQPHTNQEKIKARIQRLKEEYAATWHHDKDHPYRTWTYHGSYEVKPTGSASSLVNGVVRLMSKPWDAILNVTTMAMTDTTPFGQQRVFKEKVDTKAPEPPSGVREVMDETTNWLWAFLAREKKPRLCTREEFKRKVNSNAALGAMFEEQNQWSSAREAVEDPRFWEMVDEERENHLKGECHTCIYNMMGKREKKLGEFGKAKGSRAIWFMWLGARFLEFEALGFLNEDHWLGRKNSGGGVEGLGVQKLGYILREMSHHSGGKMYADDTAGWDTRITRADLDNEAKVLELMEGEHRQLARAIIELTYKHKVVKVMRPGTDGKTVMDVISREDQRGSGQVVTYALNTFTNIAVQLIRLMEAEGVIGQEHLESLPRKTKYAVRTWLFENGEERVTRMAVSGDDCVVKPLDDRFANALHFLNSMSKVRKDVPEWKPSSGWHDWQQVPFCSNHFQELIMKDGRTLVVPCRGQDELIGRARVSPGSGWNVRDTACLAKAYAQMWLLLYFHRRDLRLMANAICSAVPSNWVPTGRTSWSVHATGEWMTTDDMLEVWNKVWIQDNEWMLDKTPVQSWTDIPYTGKREDIWCGSLIGTRTRATWAENIYAAINQVRAIIGQEKYRDYMLSLRRYEEVNVQEDRVL
Comments:
Replicates the viral, and performs the capping of genomes in the cytoplasm. NS5 methylates viral RNA cap at guanine N-7 and ribose 2'-O positions.
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Structure and function of the NS5 methyltransferase domain from Usutu virus |
Diego S Ferrero 1, Laura Albentosa-González 2, Antonio Mas 3, Nuria Verdaguer |
|
[details]
|
36334638
|
10.1016/j.antiviral.2022.105460
|