Modomics - A Database of RNA Modifications

ID Card:

Full name: rRNA N6-adenosine-methyltransferase Mettl5
UniProt: Q8MSW4
Alpha Fold Predicted Structure: AF-Q8MSW4-F1
Enzyme type: methyltiotransferase



Protein sequence:

MARLKLRKLEEYLQGVDGFEQPKILLEQYPTPPHIAACMAHHMQSQHEDIEGKLVGDLGCGCGMLSIASTLLGAQLTVGFELDGDAVDTFRGNVVEMELPNVDCVRADVLQLIGSKWEKSFDTVLMNPPFGTKHNAGMDMRFLEVALRLANRAVYSLHKTSTRSYIQKKALEWGARGSVVAELRYNIDASYKFHKQKSKDIEVDFWRFEIGTE

Comments:

Catalytic subunit of a heterodimer with Trmt112, which specifically methylates the 6th position of adenine in 18S rRNA.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A R L K L R K L E E Y L Q G V D G F E Q P K I L L E Q Y P T P P H I A A C M A H H M Q S Q H E D I E G K L V G D L G C G C G M L S I A S T L L G A Q L T V G F E L D G D A V D T F R G N V V E M E L P N V D C V R A D V L Q L I G S K W E K S F D T V L M N P P F G T K H N A G M D M R F L E V A L R L A N R A V Y S L H K T S T R S Y I Q K K A L E W G A R G S V V A E L R Y N I D A S Y K F H K Q K S K D I E V D F W R F E I G T E

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q8MSW4-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q8MSW4-F1.cif  
DSSP Secondary Structures   Q8MSW4.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
The 18S ribosomal RNA m6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Jessica Leismann # 1, Mariangela Spagnuolo # 1, Mihika Pradhan 1, Ludivine Wacheul 2, Minh Anh Vu 1, Michael Musheev 1, Pablo Mier 3, Miguel A Andrade-Navarro 3, Marc Graille 4, Christof Niehrs 1 5, Denis Lj Lafontaine 2, Jean-Yves Roignant 1 [details] 32350990 10.15252/embr.201949443