Modomics - A Database of RNA Modifications

ID Card:

Full name: NAD-capped RNA hydrolase NudC
GI: 1036413219
UniProt: P32664
Structures: | 1VK6 | 2GB5 | 5ISY | 5IW4 | 5IW5 | 7E44 |
Alpha Fold Predicted Structure: AF-P32664-F1
Enzyme type: hydrolase


PDB Structures:


1VK6

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   1VK6.pdb   2GB5.pdb   5ISY.pdb   5IW4.pdb   5IW5.pdb   7E44.pdb  
Pdbx/mmCIF Files   1VK6.cif   2GB5.cif   5ISY.cif   5IW4.cif   5IW5.cif   7E44.cif  


Protein sequence:

MDRIIEKLDHGWWVVSHEQKLWLPKGELPYGEAANFDLVGQRALQIGEWQGEPVWLVQQQRRHDMGSVRQVIDLDVGLFQLAGRGVQLAEFYRSHKYCGYCGHEMYPSKTEWAMLCSHCRERYYPQIAPCIIVAIRRDDSILLAQHTRHRNGVHTVLAGFVEVGETLEQAVAREVMEESGIKVKNLRYVTSQPWPFPQSLMTAFMAEYDSGDIVIDPKELLEANWYRYDDLPLLPPPGTVARRLIEDTVAMCRAEYE

Comments:

mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. Has preference for mRNAs with a 5'-end purine.





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M D R I I E K L D H G W W V V S H E Q K L W L P K G E L P Y G E A A N F D L V G Q R A L Q I G E W Q G E P V W L V Q Q Q R R H D M G S V R Q V I D L D V G L F Q L A G R G V Q L A E F Y R S H K Y C G Y C G H E M Y P S K T E W A M L C S H C R E R Y Y P Q I A P C I I V A I R R D D S I L L A Q H T R H R N G V H T V L A G F V E V G E T L E Q A V A R E V M E E S G I K V K N L R Y V T S Q P W P F P Q S L M T A F M A E Y D S G D I V I D P K E L L E A N W Y R Y D D L P L L P P P G T V A R R L I E D T V A M C R A E Y E

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P32664-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P32664-F1.cif  
DSSP Secondary Structures   P32664.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke Nat Commun [details] 33139726 -
"NAD-capQ" detection and quantitation of NAD caps. Ewa Grudzien-Nogalska,Jeremy G Bird,Bryce E Nickels,Megerditch Kiledjian RNA [details] 30045887 -
Identification of a quality-control mechanism for mRNA 5'-end capping. Xinfu Jiao,Song Xiang,Chanseok Oh,Charles E Martin,Liang Tong,Megerditch Kiledjian Nature [details] 20802481 -