Modomics - A Database of RNA Modifications

ID Card:

Full name: NAD-capped RNA hydrolase NPY1
Synonym: NPY1 YGL067W
GI: 1723847
UniProt: P53164
Alpha Fold Predicted Structure: AF-P53164-F1
Enzyme type: hydrolase



Protein sequence:

MSTAVTFFGQHVLNRVSFLRCSKEFIKKSLNHDSTVFIPFIEGEALISPENGDLVQLSNSVKSYKNILSAIVPLYTTLLNTTRSRSDESGINVTFLGLLEGTDSAFNFEWSNISYKGTPYFGLDIRVTESTLFKKVDFEPIFSYPKVTRDHIFKQTNEDASLYSQGKMYLDWLAKYKFCPGCGSPLFPVEAGTKLQCSNENRNVYCNVRDARINNVCFPRTDPTVIIALTNSDYSKCCLARSKKRYGDFVLYSTIAGFMEPSETIEEACIREIWEETGISCKNIDIVRSQPWPYPCSLMIGCLGIVQFNSKNEVINLNHDDELLDAQWFDTTEIIQALDKYAGGYRVPFKNDINLPGSTTIAFQLINHVCENYKNLRKTSSSHL

Comments:

NAD-RNA decapping enzyme - hydrolyzes the pyrophosphate bond in NAD to yield nicotinamide mononucleotide (NMN) and adenosine monophosphate (AMP).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M S T A V T F F G Q H V L N R V S F L R C S K E F I K K S L N H D S T V F I P F I E G E A L I S P E N G D L V Q L S N S V K S Y K N I L S A I V P L Y T T L L N T T R S R S D E S G I N V T F L G L L E G T D S A F N F E W S N I S Y K G T P Y F G L D I R V T E S T L F K K V D F E P I F S Y P K V T R D H I F K Q T N E D A S L Y S Q G K M Y L D W L A K Y K F C P G C G S P L F P V E A G T K L Q C S N E N R N V Y C N V R D A R I N N V C F P R T D P T V I I A L T N S D Y S K C C L A R S K K R Y G D F V L Y S T I A G F M E P S E T I E E A C I R E I W E E T G I S C K N I D I V R S Q P W P Y P C S L M I G C L G I V Q F N S K N E V I N L N H D D E L L D A Q W F D T T E I I Q A L D K Y A G G Y R V P F K N D I N L P G S T T I A F Q L I N H V C E N Y K N L R K T S S S H L

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P53164-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P53164-F1.cif  
DSSP Secondary Structures   P53164.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Extensive 5'-surveillance guards against non-canonical NAD-caps of nuclear mRNAs in yeast. Yaqing Zhang,David Kuster,Tobias Schmidt,Daniel Kirrmaier,Gabriele Nübel,David Ibberson,Vladimir Benes,Hans Hombauer,Michael Knop,Andres Jäschke Nat Commun [details] 33139726 -
The NADH diphosphatase encoded by the Saccharomyces cerevisiae NPY1 nudix hydrolase gene is located in peroxisomes. S R AbdelRaheim,J L Cartwright,L Gasmi,A G McLennan Arch Biochem Biophys [details] 11361135 -