ID Card:
Full name:
tRNA N(3)-methylcytidine methyltransferase
GI:
317373413
UniProt:
Q6P1Q9
Alpha Fold Predicted Structure:
AF-Q6P1Q9-F1
Complex:
DALRD3 (for tRNA Arg substrate)
Enzyme type:
methyltransferase
Protein sequence:
MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVCECRNNEDGPGLIMEEQHKCSSKSLEHKTQTPPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLLKPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
Comments:
METTL2B (similarly to METTL2A) mediates N3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU). The activity of METTL2 towards tRNA substrates is reduced to 1/10 in comparison to METTL2A. METTL2B protein carries 6 single amino acid substitutions comparing to METTL2A (V12I, R26S, P124C, L155P, I266V, M288V).
Alpha Fold Predicted Structure:
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Protein sequence:
M
A
G
S
Y
P
E
G
A
P
A
I
L
A
D
K
R
Q
Q
F
G
S
R
F
L
S
D
P
A
R
V
F
H
H
N
A
W
D
N
V
E
W
S
E
E
Q
A
A
A
A
E
R
K
V
Q
E
N
S
I
Q
R
V
C
Q
E
K
Q
V
D
Y
E
I
N
A
H
K
Y
W
N
D
F
Y
K
I
H
E
N
G
F
F
K
D
R
H
W
L
F
T
E
F
P
E
L
A
P
S
Q
N
Q
N
H
L
K
D
W
F
L
E
N
K
S
E
V
C
E
C
R
N
N
E
D
G
P
G
L
I
M
E
E
Q
H
K
C
S
S
K
S
L
E
H
K
T
Q
T
P
P
V
E
E
N
V
T
Q
K
I
S
D
L
E
I
C
A
D
E
F
P
G
S
S
A
T
Y
R
I
L
E
V
G
C
G
V
G
N
T
V
F
P
I
L
Q
T
N
N
D
P
G
L
F
V
Y
C
C
D
F
S
S
T
A
I
E
L
V
Q
T
N
S
E
Y
D
P
S
R
C
F
A
F
V
H
D
L
C
D
E
E
K
S
Y
P
V
P
K
G
S
L
D
I
I
I
L
I
F
V
L
S
A
V
V
P
D
K
M
Q
K
A
I
N
R
L
S
R
L
L
K
P
G
G
M
V
L
L
R
D
Y
G
R
Y
D
M
A
Q
L
R
F
K
K
G
Q
C
L
S
G
N
F
Y
V
R
G
D
G
T
R
V
Y
F
F
T
Q
E
E
L
D
T
L
F
T
T
A
G
L
E
K
V
Q
N
L
V
D
R
R
L
Q
V
N
R
G
K
Q
L
T
M
Y
R
V
W
I
Q
C
K
Y
C
K
P
L
L
S
S
T
S
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans.
Xu L, Liu X, Sheng N, Oo KS, Liang J, Chionh YH, Xu J, Ye F, Gao YG, Dedon PC, Fu XY
J Biol Chem
[details]
28655767
10.1074/jbc.M117.798298