ID Card:
| Full name: |
Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4b |
| Synonym: |
tRNA (cytosine-5-)-methyltransferase trm4b |
| UniProt: |
O13935 |
| Alpha Fold Predicted Structure: |
AF-O13935-F1 |
| Complex: |
none |
| Enzyme type: |
methyltransferase |
Protein sequence:
MGKRNKKVTQGKRAYNDKSEIVLENKQFEGYYKKQNLFRGKPNDEFDSFMEYMRKPLPTTFRICGYRHHAFELKNHFEKYYVPSLKNVVHEGQTIPPPTVLPWYPDGLAYIVDAQKDVIRKSPPLKRLQRFLVSENEAGNINRQEAVSMLPPLFLDVEPHHVILDMCAAPGSKTAQLIEAVYKKANIKDAAHDSKNLKSVEGLVIANDADPKRAQMLVHQINRLNSPNILVVNHDASTMPNIYVKGSSPSDGLNVIEEKKILKFDRILADVPCSGDGTFRKNLSLWREWSANSAFSLHPLQLRILIRGLQLLKVGGCLVYSTCSINPIENEAVVTAALKATGGAVSLVDVSKKLPLLKRDPGLLSWKVLDDSLNEFQSPAENTNDKIELTESMWPLPEEEMSKLHIERCARLYPHMQNTGGFFVAVLQKTDPINSRSFDPKKYTASMEILPPENKRQRTEKGVDEASNSTLTKSGNSYFDEEPFVYINPDDTSIKTIVDFYGIDPSFPRDQFFVRNQSGIPVRSIYFACSLFKEIIEANTNRVKFVHGGVRFFVKQEISQLLKDFSLKANKDICNFRIHSNGVNIISPFLNEKHFYDAGLKDLKILVKNEYPHVEQFSESGMLKKEFEKMPLGCNILRVDAQTKDGALMDMLILQPIWRSPTSCNLMLARKEKQNLSLELFGMDV
Comments:
Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences
Alpha Fold Predicted Structure:
Clear Selection and Reset Camera
Protein sequence:
M
G
K
R
N
K
K
V
T
Q
G
K
R
A
Y
N
D
K
S
E
I
V
L
E
N
K
Q
F
E
G
Y
Y
K
K
Q
N
L
F
R
G
K
P
N
D
E
F
D
S
F
M
E
Y
M
R
K
P
L
P
T
T
F
R
I
C
G
Y
R
H
H
A
F
E
L
K
N
H
F
E
K
Y
Y
V
P
S
L
K
N
V
V
H
E
G
Q
T
I
P
P
P
T
V
L
P
W
Y
P
D
G
L
A
Y
I
V
D
A
Q
K
D
V
I
R
K
S
P
P
L
K
R
L
Q
R
F
L
V
S
E
N
E
A
G
N
I
N
R
Q
E
A
V
S
M
L
P
P
L
F
L
D
V
E
P
H
H
V
I
L
D
M
C
A
A
P
G
S
K
T
A
Q
L
I
E
A
V
Y
K
K
A
N
I
K
D
A
A
H
D
S
K
N
L
K
S
V
E
G
L
V
I
A
N
D
A
D
P
K
R
A
Q
M
L
V
H
Q
I
N
R
L
N
S
P
N
I
L
V
V
N
H
D
A
S
T
M
P
N
I
Y
V
K
G
S
S
P
S
D
G
L
N
V
I
E
E
K
K
I
L
K
F
D
R
I
L
A
D
V
P
C
S
G
D
G
T
F
R
K
N
L
S
L
W
R
E
W
S
A
N
S
A
F
S
L
H
P
L
Q
L
R
I
L
I
R
G
L
Q
L
L
K
V
G
G
C
L
V
Y
S
T
C
S
I
N
P
I
E
N
E
A
V
V
T
A
A
L
K
A
T
G
G
A
V
S
L
V
D
V
S
K
K
L
P
L
L
K
R
D
P
G
L
L
S
W
K
V
L
D
D
S
L
N
E
F
Q
S
P
A
E
N
T
N
D
K
I
E
L
T
E
S
M
W
P
L
P
E
E
E
M
S
K
L
H
I
E
R
C
A
R
L
Y
P
H
M
Q
N
T
G
G
F
F
V
A
V
L
Q
K
T
D
P
I
N
S
R
S
F
D
P
K
K
Y
T
A
S
M
E
I
L
P
P
E
N
K
R
Q
R
T
E
K
G
V
D
E
A
S
N
S
T
L
T
K
S
G
N
S
Y
F
D
E
E
P
F
V
Y
I
N
P
D
D
T
S
I
K
T
I
V
D
F
Y
G
I
D
P
S
F
P
R
D
Q
F
F
V
R
N
Q
S
G
I
P
V
R
S
I
Y
F
A
C
S
L
F
K
E
I
I
E
A
N
T
N
R
V
K
F
V
H
G
G
V
R
F
F
V
K
Q
E
I
S
Q
L
L
K
D
F
S
L
K
A
N
K
D
I
C
N
F
R
I
H
S
N
G
V
N
I
I
S
P
F
L
N
E
K
H
F
Y
D
A
G
L
K
D
L
K
I
L
V
K
N
E
Y
P
H
V
E
Q
F
S
E
S
G
M
L
K
K
E
F
E
K
M
P
L
G
C
N
I
L
R
V
D
A
Q
T
K
D
G
A
L
M
D
M
L
I
L
Q
P
I
W
R
S
P
T
S
C
N
L
M
L
A
R
K
E
K
Q
N
L
S
L
E
L
F
G
M
D
V
Secondary Structure Alphabet
- G: 3-turn helix (310helix)
- H: α-helix
- I: 𝝅-helix (5 - turn helix)
- T: Hydrogen Bonded Turn
- B: β-sheet
- S: Bend
- C: Coil (residues not present in any of the above conformations)
- N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
| Title |
Authors |
Journal |
Details |
PubMed Id |
DOI |
| Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. |
Martin Müller,Anke Samel-Pommerencke,Carine Legrand,Francesca Tuorto,Frank Lyko,Ann E Ehrenhofer-Murray |
RNA Biol |
[details]
|
30646830
|
-
|
| Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. |
Maria Becker,Sara Müller,Wolfgang Nellen,Tomasz P Jurkowski,Albert Jeltsch,Ann E Ehrenhofer-Murray |
Nucleic Acids Res |
[details]
|
23074192
|
-
|