Modomics - A Database of RNA Modifications

ID Card:

Full name: Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4a
Synonym: Multisite-specific tRNA:(cytosine-C(5))-methyltransferase trm4a
UniProt: Q9HGQ2
Alpha Fold Predicted Structure: AF-Q9HGQ2-F1
Complex: none
Enzyme type: methyltransferase



Protein sequence:

MGRKHYSSKKNRSKKGEFVNWDLIERKNENFEKYYRLQKLVTEDDFILLKQKLTEQLPTTFRITASIPHATQVRDYFIEHYYPLIENARTEDAKIPLPVSLPWYPDGMAFMLDISKEVIRKSPHLKALQEFLVLETEAGDINRQESVSMVPPLLLNVESHHKVLDMCAAPGSKTAQLLEALHKPTKKEDITTLLPSGIVIANDSDNKRAHMLVHQIKRLNSPNVLIVNHDASFLPNFHLSSPDGKKFLKFDRILADVPCSGDGTFRKNIALWNEWSLKTALGLHATQIKILMRGLQLLEKGGRLVYSTCSLNPIENEAVVSAVLNATRGSVRLVDVSSELPQLKRSQGVDNWVVCDSDLNIYPSFDTLPKELYEKMPPTLWPLPKKELAELNIQNCLRIYPHFQNTGGFFVAVLEKYENLTSSMKTAVDDNKVFLREQKLPSEQASKKRKQDTQETSSDSKLAEVKPKGKNGGNRFHELDPFVYIKEDDQALEKIYKKFGIDEAIIKKNQFFVRNVNGVPTKAIYISNDLFRNVIENNRNRVKFVHGGLKIFVRQDFGSLSREIAEKNGTCVFRVQSDGANLASHFIAESCLFHTTLSDLFILLDHEAVTIDDFPEDSLFRKEYNHLDLGSTLLHVDLAKEESVIKKQVYIPLWKSVRICNVLLSNSEKRTLKLQIEGPQSSIHKHNT

Comments:





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M G R K H Y S S K K N R S K K G E F V N W D L I E R K N E N F E K Y Y R L Q K L V T E D D F I L L K Q K L T E Q L P T T F R I T A S I P H A T Q V R D Y F I E H Y Y P L I E N A R T E D A K I P L P V S L P W Y P D G M A F M L D I S K E V I R K S P H L K A L Q E F L V L E T E A G D I N R Q E S V S M V P P L L L N V E S H H K V L D M C A A P G S K T A Q L L E A L H K P T K K E D I T T L L P S G I V I A N D S D N K R A H M L V H Q I K R L N S P N V L I V N H D A S F L P N F H L S S P D G K K F L K F D R I L A D V P C S G D G T F R K N I A L W N E W S L K T A L G L H A T Q I K I L M R G L Q L L E K G G R L V Y S T C S L N P I E N E A V V S A V L N A T R G S V R L V D V S S E L P Q L K R S Q G V D N W V V C D S D L N I Y P S F D T L P K E L Y E K M P P T L W P L P K K E L A E L N I Q N C L R I Y P H F Q N T G G F F V A V L E K Y E N L T S S M K T A V D D N K V F L R E Q K L P S E Q A S K K R K Q D T Q E T S S D S K L A E V K P K G K N G G N R F H E L D P F V Y I K E D D Q A L E K I Y K K F G I D E A I I K K N Q F F V R N V N G V P T K A I Y I S N D L F R N V I E N N R N R V K F V H G G L K I F V R Q D F G S L S R E I A E K N G T C V F R V Q S D G A N L A S H F I A E S C L F H T T L S D L F I L L D H E A V T I D D F P E D S L F R K E Y N H L D L G S T L L H V D L A K E E S V I K K Q V Y I P L W K S V R I C N V L L S N S E K R T L K L Q I E G P Q S S I H K H N T

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9HGQ2-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9HGQ2-F1.cif  
DSSP Secondary Structures   Q9HGQ2.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
Division of labour: tRNA methylation by the NSun2 tRNA methyltransferases Trm4a and Trm4b in fission yeast. Martin Müller,Anke Samel-Pommerencke,Carine Legrand,Francesca Tuorto,Frank Lyko,Ann E Ehrenhofer-Murray RNA Biol [details] 30646830 -
Pmt1, a Dnmt2 homolog in Schizosaccharomyces pombe, mediates tRNA methylation in response to nutrient signaling. Maria Becker,Sara Müller,Wolfgang Nellen,Tomasz P Jurkowski,Albert Jeltsch,Ann E Ehrenhofer-Murray Nucleic Acids Res [details] 23074192 -