Modomics - A Database of RNA Modifications

ID Card:

Full name:	TLE family member 5, transcriptional modulator
Synonym:	GRG5
GI:	23503062
UniProt:	Q08117
Alpha Fold Predicted Structure:	AF-Q08117-F1

Protein sequence:

MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD

Comments:

Alpha Fold Predicted Structure:

Clear Selection and Reset Camera

Protein sequence:

M M F P Q S R H S G S S H L P Q Q L K F T T S D S C D R I K D E F Q L L Q A Q Y H S L K L E C D K L A S E K S E M Q R H Y V M Y Y E M S Y G L N I E M H K Q A E I V K R L N G I C A Q V L P Y L S Q E H Q Q Q V L G A I E R A K Q V T A P E L N S I I R Q Q L Q A H Q L S Q L Q A L A L P L T P L P V G L Q P P S L P A V S A G T G L L S L S A L G S Q A H L S K E D K N G H D G D T H Q E D D G E K S D

Secondary Structure Alphabet

G: 3-turn helix (3₁₀helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files	AF-Q08117-F1.pdb
Alpha Fold Pdbx/mmCIF Files	AF-Q08117-F1.cif
DSSP Secondary Structures	Q08117.dssp

Diseases connected to this enzyme:

Description	Reaction	Disease Name
Loss of 2'-O-Me results in decreased leukemia self-renewal potential and reduced colony formation potential.	N:Nm	Leukemia

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI