Modomics - A Database of RNA Modifications

ID Card:

Full name:	NOP2/Sun RNA methyltransferase 2
Synonym:	FLJ20303,TRM4,Misu
GI:	148887180
UniProt:	Q08J23
Alpha Fold Predicted Structure:	AF-Q08J23-F1

Protein sequence:

MGRRSRGRRLQQQQRPEDAEDGAEGGGKRGEAGWEGGYPEIVKENKLFEHYYQELKIVPEGEWGQFMDALREPLPATLRITGYKSHAKEILHCLKNKYFKELEDLEVDGQKVEVPQPLSWYPEELAWHTNLSRKILRKSPHLEKFHQFLVSETESGNISRQEAVSMIPPLLLNVRPHHKILDMCAAPGSKTTQLIEMLHADMNVPFPEGFVIANDVDNKRCYLLVHQAKRLSSPCIMVVNHDASSIPRLQIDVDGRKEILFYDRILCDVPCSGDGTMRKNIDVWKKWTTLNSLQLHGLQLRIATRGAEQLAEGGRMVYSTCSLNPIEDEAVIASLLEKSEGALELADVSNELPGLKWMPGITQWKVMTKDGQWFTDWDAVPHSRHTQIRPTMFPPKDPEKLQAMHLERCLRILPHHQNTGGFFVAVLVKKSSMPWNKRQPKLQGKSAETRESTQLSPADLTEGKPTDPSKLESPSFTGTGDTEIAHATEDLENNGSKKDGVCGPPPSKKMKLFGFKEDPFVFIPEDDPLFPPIEKFYALDPSFPRMNLLTRTTEGKKRQLYMVSKELRNVLLNNSEKMKVINTGIKVWCRNNSGEEFDCAFRLAQEGIYTLYPFINSRIITVSMEDVKILLTQENPFFRKLSSETYSQAKDLAKGSIVLKYEPDSANPDALQCPIVLCGWRGKASIRTFVPKNERLHYLRMMGLEVLGEKKKEGVILTNESAASTGQPDNDVTEGQRAGEPNSPDAEEANSPDVTAGCDPAGVHPPR

Comments:

Alpha Fold Predicted Structure:

Clear Selection and Reset Camera

Protein sequence:

M G R R S R G R R L Q Q Q Q R P E D A E D G A E G G G K R G E A G W E G G Y P E I V K E N K L F E H Y Y Q E L K I V P E G E W G Q F M D A L R E P L P A T L R I T G Y K S H A K E I L H C L K N K Y F K E L E D L E V D G Q K V E V P Q P L S W Y P E E L A W H T N L S R K I L R K S P H L E K F H Q F L V S E T E S G N I S R Q E A V S M I P P L L L N V R P H H K I L D M C A A P G S K T T Q L I E M L H A D M N V P F P E G F V I A N D V D N K R C Y L L V H Q A K R L S S P C I M V V N H D A S S I P R L Q I D V D G R K E I L F Y D R I L C D V P C S G D G T M R K N I D V W K K W T T L N S L Q L H G L Q L R I A T R G A E Q L A E G G R M V Y S T C S L N P I E D E A V I A S L L E K S E G A L E L A D V S N E L P G L K W M P G I T Q W K V M T K D G Q W F T D W D A V P H S R H T Q I R P T M F P P K D P E K L Q A M H L E R C L R I L P H H Q N T G G F F V A V L V K K S S M P W N K R Q P K L Q G K S A E T R E S T Q L S P A D L T E G K P T D P S K L E S P S F T G T G D T E I A H A T E D L E N N G S K K D G V C G P P P S K K M K L F G F K E D P F V F I P E D D P L F P P I E K F Y A L D P S F P R M N L L T R T T E G K K R Q L Y M V S K E L R N V L L N N S E K M K V I N T G I K V W C R N N S G E E F D C A F R L A Q E G I Y T L Y P F I N S R I I T V S M E D V K I L L T Q E N P F F R K L S S E T Y S Q A K D L A K G S I V L K Y E P D S A N P D A L Q C P I V L C G W R G K A S I R T F V P K N E R L H Y L R M M G L E V L G E K K K E G V I L T N E S A A S T G Q P D N D V T E G Q R A G E P N S P D A E E A N S P D V T A G C D P A G V H P P R

Secondary Structure Alphabet

G: 3-turn helix (3₁₀helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files	AF-Q08J23-F1.pdb
Alpha Fold Pdbx/mmCIF Files	AF-Q08J23-F1.cif
DSSP Secondary Structures	Q08J23.dssp

Diseases connected to this enzyme:

Description	Reaction	Disease Name
In patient cells, a functional NSUN2 protein is lacking. NSUN2-depletion causes growth retardation, mild microcephaly, and learning disabilities.	C:m5C	Dubowitz-like Syndrome
NSUN2 and YBX1 stabilize the oncogene mRNA of the oncogene HDGF that mediates UCB pathogenesis in human	C:m5C	Urothelial carcinoma of the bladder (UCB)
Loss of m5C causes the accumulation of tRNA fragments in the absence of NSUN2. Therefore, reduction in protein translation rates and activation in stress pathways leading to reduced cell size and increased apoptosis of cortical, hippocampal, and striatal neurons occurred.	C:m5C	Neuro-developmental disorder
NSUN2 affects the stability and nuclear-cytoplasmic shuttling of mRNAs, non-coding RNAs, and tRNAs.High NSUN2 expression is associated with poor survival rates.	C:m5C	Head and neck squamous cell carcinoma (HNSCC)
NSun2 overexpression is related to poor prognosis.	C:m5C	Gastric cancer
Increased levels of NSUN2 methylated lncRNA is a key regulator of ESCC tumor metastasis and drug resistance.	C:m5C	Esophageal squamous cell carcinoma

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI