Modomics - A Database of RNA Modifications

ID Card:

Full name: YTH domain containing 2
Synonym: FLJ2194,FLJ10053,DKFZp564A186
GI: 239938805
UniProt: Q9H6S0
Structures: | 2YU6 | 6K6U | 6LR2 |
Alpha Fold Predicted Structure: AF-Q9H6S0-F1


PDB Structures:


2YU6

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Yet to be published

Download RCSB-PDB Structures:

Pdb Files   2YU6.pdb   6K6U.pdb   6LR2.pdb  
Pdbx/mmCIF Files   2YU6.cif   6K6U.cif   6LR2.cif  


Protein sequence:

MSRPSSVSPRQPAPGGGGGGGPSPCGPGGGGRAKGLKDIRIDEEVKIAVNIALERFRYGDQREMEFPSSLTSTERAFIHRLSQSLGLVSKSKGKGANRYLTVKKKDGSETAHAMMTCNLTHNTKHAVRSLIQRFPVTNKERTELLPKTERGNVFAVEAENREMSKTSGRLNNGIPQIPVKRGESEFDSFRQSLPVFEKQEEIVKIIKENKVVLIVGETGSGKTTQIPQFLLDDCFKNGIPCRIFCTQPRRLAAIAVAERVAAERRERIGQTIGYQIRLESRVSPKTLLTFCTNGVLLRTLMAGDSTLSTVTHVIVDEVHERDRFSDFLLTKLRDLLQKHPTLKLILSSAALDVNLFIRYFGSCPVIYIQGRPFEVKEMFLEDILRTTGYTNKEMLKYKKEKQQEEKQQTTLTEWYSAQENSFKPESQRQRTVLNVTDEYDLLDDGGDAVFSQLTEKDVNCLEPWLIKEMDACLSDIWLHKDIDAFAQVFHLILTENVSVDYRHSETSATALMVAAGRGFASQVEQLISMGANVHSKASNGWMALDWAKHFGQTEIVDLLESYSATLEFGNLDESSLVQTNGSDLSAEDRELLKAYHHSFDDEKVDLDLIMHLLYNICHSCDAGAVLIFLPGYDEIVGLRDRILFDDKRFADSTHRYQVFMLHSNMQTSDQKKVLKNPPAGVRKIILSTNIAETSITVNDVVFVIDSGKVKEKSFDALNFVTMLKMVWISKASAIQRKGRAGRCRPGICFRLFSRLRFQNMLEFQTPELLRMPLQELCLHTKLLAPVNCPIADFLMKAPEPPPALIVRNAVQMLKTIDAMDTWEDLTELGYHLADLPVEPHLGKMVLCAVVLKCLDPILTIACTLAYRDPFVLPTQASQKRAAMLCRKRFTAGAFSDHMALLRAFQAWQKARSDGWERAFCEKNFLSQATMEIIIGMRTQLLGQLRASGFVRARGGGDIRDVNTNSENWAVVKAALVAGMYPNLVHVDRENLVLTGPKEKKVRFHPASVLSQPQYKKIPPANGQAAAIKALPTDWLIYDEMTRAHRIANIRCCSAVTPVTILVFCGPARLASNALQEPSSFRVDGIPNDSSDSEMEDKTTANLAALKLDEWLHFTLEPEAASLLLQLRQKWHSLFLRRMRAPSKPWSQVDEATIRAIIAVLSTEEQSAGLQQPSGIGQRPRPMSSEELPLASSWRSNNSRKSSADTEFSDECTTAERVLMKSPSPALHPPQKYKDRGILHPKRGTEDRSDQSSLKSTDSSSYPSPCASPSPPSSGKGSKSPSPRPNMPVRYFIMKSSNLRNLEISQQKGIWSTTPSNERKLNRAFWESSIVYLVFSVQGSGHFQGFSRMSSEIGREKSQDWGSAGLGGVFKVEWIRKESLPFQFAHHLLNPWNDNKKVQISRDGQELEPLVGEQLLQLWERLPLGEKNTTD

Comments:

None





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M S R P S S V S P R Q P A P G G G G G G G P S P C G P G G G G R A K G L K D I R I D E E V K I A V N I A L E R F R Y G D Q R E M E F P S S L T S T E R A F I H R L S Q S L G L V S K S K G K G A N R Y L T V K K K D G S E T A H A M M T C N L T H N T K H A V R S L I Q R F P V T N K E R T E L L P K T E R G N V F A V E A E N R E M S K T S G R L N N G I P Q I P V K R G E S E F D S F R Q S L P V F E K Q E E I V K I I K E N K V V L I V G E T G S G K T T Q I P Q F L L D D C F K N G I P C R I F C T Q P R R L A A I A V A E R V A A E R R E R I G Q T I G Y Q I R L E S R V S P K T L L T F C T N G V L L R T L M A G D S T L S T V T H V I V D E V H E R D R F S D F L L T K L R D L L Q K H P T L K L I L S S A A L D V N L F I R Y F G S C P V I Y I Q G R P F E V K E M F L E D I L R T T G Y T N K E M L K Y K K E K Q Q E E K Q Q T T L T E W Y S A Q E N S F K P E S Q R Q R T V L N V T D E Y D L L D D G G D A V F S Q L T E K D V N C L E P W L I K E M D A C L S D I W L H K D I D A F A Q V F H L I L T E N V S V D Y R H S E T S A T A L M V A A G R G F A S Q V E Q L I S M G A N V H S K A S N G W M A L D W A K H F G Q T E I V D L L E S Y S A T L E F G N L D E S S L V Q T N G S D L S A E D R E L L K A Y H H S F D D E K V D L D L I M H L L Y N I C H S C D A G A V L I F L P G Y D E I V G L R D R I L F D D K R F A D S T H R Y Q V F M L H S N M Q T S D Q K K V L K N P P A G V R K I I L S T N I A E T S I T V N D V V F V I D S G K V K E K S F D A L N F V T M L K M V W I S K A S A I Q R K G R A G R C R P G I C F R L F S R L R F Q N M L E F Q T P E L L R M P L Q E L C L H T K L L A P V N C P I A D F L M K A P E P P P A L I V R N A V Q M L K T I D A M D T W E D L T E L G Y H L A D L P V E P H L G K M V L C A V V L K C L D P I L T I A C T L A Y R D P F V L P T Q A S Q K R A A M L C R K R F T A G A F S D H M A L L R A F Q A W Q K A R S D G W E R A F C E K N F L S Q A T M E I I I G M R T Q L L G Q L R A S G F V R A R G G G D I R D V N T N S E N W A V V K A A L V A G M Y P N L V H V D R E N L V L T G P K E K K V R F H P A S V L S Q P Q Y K K I P P A N G Q A A A I K A L P T D W L I Y D E M T R A H R I A N I R C C S A V T P V T I L V F C G P A R L A S N A L Q E P S S F R V D G I P N D S S D S E M E D K T T A N L A A L K L D E W L H F T L E P E A A S L L L Q L R Q K W H S L F L R R M R A P S K P W S Q V D E A T I R A I I A V L S T E E Q S A G L Q Q P S G I G Q R P R P M S S E E L P L A S S W R S N N S R K S S A D T E F S D E C T T A E R V L M K S P S P A L H P P Q K Y K D R G I L H P K R G T E D R S D Q S S L K S T D S S S Y P S P C A S P S P P S S G K G S K S P S P R P N M P V R Y F I M K S S N L R N L E I S Q Q K G I W S T T P S N E R K L N R A F W E S S I V Y L V F S V Q G S G H F Q G F S R M S S E I G R E K S Q D W G S A G L G G V F K V E W I R K E S L P F Q F A H H L L N P W N D N K K V Q I S R D G Q E L E P L V G E Q L L Q L W E R L P L G E K N T T D

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q9H6S0-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q9H6S0-F1.cif  
DSSP Secondary Structures   Q9H6S0.dssp  





Diseases connected to this enzyme:

Description Reaction Disease Name
A CNV-containing DNA region (which contains YTHDC2 gene) is found to be associated to pancreatic cancer risk A:m6A
Pancreatic cancer
YTHDC2 is upregulated in colorectal cancer and it contributes to colon tumor metastasis by promoting translation of HIF-1α A:m6A
Colorectal cancer

Publications:

Title Authors Journal Details PubMed Id DOI