Modomics - A Database of RNA Modifications

ID Card:

Full name:	Pseudouridylate synthase 7 homolog
Synonym:	FLJ20485
GI:	970414574
UniProt:	Q96PZ0
Structures:	\| 5KKP \|
Alpha Fold Predicted Structure:	AF-Q96PZ0-F1
Enzyme type:	pseudouridine synthase

PDB Structures:

5KKP

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Download RCSB-PDB Structures:

Pdb Files	5KKP.pdb
Pdbx/mmCIF Files	5KKP.cif

Protein sequence:

MEMTEMTGVSLKRGALVVEDNDSGVPVEETKKQKLSECSLTKGQDGLQNDFLSISEDVPRPPDTVSTGKGGKNSEAQLEDEEEEEEDGLSEECEEEESESFADMMKHGLTEADVGITKFVSSHQGFSGILKERYSDFVVHEIGKDGRISHLNDLSIPVDEEDPSEDIFTVLTAEEKQRLEELQLFKNKETSVAIEVIEDTKEKRTIIHQAIKSLFPGLETKTEDREGKKYIVAYHAAGKKALANPRKHSWPKSRGSYCHFVLYKENKDTMDAINVLSKYLRVKPNIFSYMGTKDKRAITVQEIAVLKITAQRLAHLNKCLMNFKLGNFSYQKNPLKLGELQGNHFTVVLRNITGTDDQVQQAMNSLKEIGFINYYGMQRFGTTAVPTYQVGRAILQNSWTEVMDLILKPRSGAEKGYLVKCREEWAKTKDPTAALRKLPVKRCVEGQLLRGLSKYGMKNIVSAFGIIPRNNRLMYIHSYQSYVWNNMVSKRIEDYGLKPVPGDLVLKGATATYIEEDDVNNYSIHDVVMPLPGFDVIYPKHKIQEAYREMLTADNLDIDNMRHKIRDYSLSGAYRKIIIRPQNVSWEVVAYDDPKIPLFNTDVDNLEGKTPPVFASEGKYRALKMDFSLPPSTYATMAIREVLKMDTSIKNQTQLNTTWLR

Comments:

Alpha Fold Predicted Structure:

Clear Selection and Reset Camera

Protein sequence:

M E M T E M T G V S L K R G A L V V E D N D S G V P V E E T K K Q K L S E C S L T K G Q D G L Q N D F L S I S E D V P R P P D T V S T G K G G K N S E A Q L E D E E E E E E D G L S E E C E E E E S E S F A D M M K H G L T E A D V G I T K F V S S H Q G F S G I L K E R Y S D F V V H E I G K D G R I S H L N D L S I P V D E E D P S E D I F T V L T A E E K Q R L E E L Q L F K N K E T S V A I E V I E D T K E K R T I I H Q A I K S L F P G L E T K T E D R E G K K Y I V A Y H A A G K K A L A N P R K H S W P K S R G S Y C H F V L Y K E N K D T M D A I N V L S K Y L R V K P N I F S Y M G T K D K R A I T V Q E I A V L K I T A Q R L A H L N K C L M N F K L G N F S Y Q K N P L K L G E L Q G N H F T V V L R N I T G T D D Q V Q Q A M N S L K E I G F I N Y Y G M Q R F G T T A V P T Y Q V G R A I L Q N S W T E V M D L I L K P R S G A E K G Y L V K C R E E W A K T K D P T A A L R K L P V K R C V E G Q L L R G L S K Y G M K N I V S A F G I I P R N N R L M Y I H S Y Q S Y V W N N M V S K R I E D Y G L K P V P G D L V L K G A T A T Y I E E D D V N N Y S I H D V V M P L P G F D V I Y P K H K I Q E A Y R E M L T A D N L D I D N M R H K I R D Y S L S G A Y R K I I I R P Q N V S W E V V A Y D D P K I P L F N T D V D N L E G K T P P V F A S E G K Y R A L K M D F S L P P S T Y A T M A I R E V L K M D T S I K N Q T Q L N T T W L R

Secondary Structure Alphabet

G: 3-turn helix (3₁₀helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files	AF-Q96PZ0-F1.pdb
Alpha Fold Pdbx/mmCIF Files	AF-Q96PZ0-F1.cif
DSSP Secondary Structures	Q96PZ0.dssp

Diseases connected to this enzyme:

Description	Reaction	Disease Name
Pseudouridylation level on snRNA U2 depends on expression level of scaRNA1that is linked with TOF	U:Y	Tetralogy of Fallot (TOF)
PUS7 mutations result in decreased levels of Ψ13 modifications in tRNAs	U:Y	Intellectual disability and progressive microcephaly
Variants in PUS7 cause the loss of function on pseudouridylation of mRNAs and tRNAs that leads intellectual disabilities.	U:Y	Intellectual disability

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
Pseudouridylation of tRNA-Derived Fragments Steers Translational Control in Stem Cells.	Guzzi N, Ciesla M, Ngoc PCT, Lang S, Arora S, Dimitriou M, Pimkova K, Sommarin MNE, Munita R, Lubas M, Lim Y, Okuyama K, Soneji S, Karlsson G, Hansson J, Jonsson G, Lund AH, Sigvardsson M, Hellstrom-Lindberg E, Hsieh AC, Bellodi C...	Cell	[details]	29628141	-