ID Card:
Full name:
S-adenosyl-L-methionine-dependent methyltransferase
Synonym:
YBR141C
GI:
330443457
Orf:
YBR1118
UniProt:
P38278
Alpha Fold Predicted Structure:
AF-P38278-F1
Enzyme type:
methyltransferase
Position of modification - modification:
l :2142(1784) - m1A
Protein sequence:
MHSRKSKSITGKRKQVGSNVTRVIKPQKTRRIIRRFHHLINKRQSICKFLCLKENLDDSNEEKNDKIIRLSIKGNVRLGKYYEDGKSQSFNDAMESQLLRLHSLIKNESKSKDTSDLAVMYTLLGYIMNQINKLGGLETYQIASQNGQLKERGGDTSKLLEKWIRSSFENCPGAVALEIGSLSSGNRISRCALFRNVVRIDLEEHEGVIKQDFMERPLPRNENDKFDLISCSLVLNFVKNHRDRGAMCHRMVKFLKPQGYIFIVLPQACVTHSRYCDKTLLQNLLGSIGLIMLNSHQSNKLYYCLYQLQVVPPQPSSFSKRIKVNDGPGLNNFGITL
Comments:
S-adenosyl-L-methionine-dependant methyltransferase specifically methylates the N1 position of A2142 in the rRNA LSU-25s. It is predicted to be an Ado-Met dependent methyltransferase from the Rossmann fold superfamily. Noteworthy, LSU-25s is in the domain IV helix 65 region of LSU-25s that accounts for most of the surface of LSU-25s. The loss of m1A2142 modification confers anisomycin and peroxide sensitivity to the cells (Sharma et al. 2013 ).
Alpha Fold Predicted Structure:
Parsing response... [270074/315041]
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Protein sequence:
M
H
S
R
K
S
K
S
I
T
G
K
R
K
Q
V
G
S
N
V
T
R
V
I
K
P
Q
K
T
R
R
I
I
R
R
F
H
H
L
I
N
K
R
Q
S
I
C
K
F
L
C
L
K
E
N
L
D
D
S
N
E
E
K
N
D
K
I
I
R
L
S
I
K
G
N
V
R
L
G
K
Y
Y
E
D
G
K
S
Q
S
F
N
D
A
M
E
S
Q
L
L
R
L
H
S
L
I
K
N
E
S
K
S
K
D
T
S
D
L
A
V
M
Y
T
L
L
G
Y
I
M
N
Q
I
N
K
L
G
G
L
E
T
Y
Q
I
A
S
Q
N
G
Q
L
K
E
R
G
G
D
T
S
K
L
L
E
K
W
I
R
S
S
F
E
N
C
P
G
A
V
A
L
E
I
G
S
L
S
S
G
N
R
I
S
R
C
A
L
F
R
N
V
V
R
I
D
L
E
E
H
E
G
V
I
K
Q
D
F
M
E
R
P
L
P
R
N
E
N
D
K
F
D
L
I
S
C
S
L
V
L
N
F
V
K
N
H
R
D
R
G
A
M
C
H
R
M
V
K
F
L
K
P
Q
G
Y
I
F
I
V
L
P
Q
A
C
V
T
H
S
R
Y
C
D
K
T
L
L
Q
N
L
L
G
S
I
G
L
I
M
L
N
S
H
Q
S
N
K
L
Y
Y
C
L
Y
Q
L
Q
V
V
P
P
Q
P
S
S
F
S
K
R
I
K
V
N
D
G
P
G
L
N
N
F
G
I
T
L
50 100 150 200 250 300 Sequence G H T B S N
Secondary Structure Alphabet
G: 3-turn helix (310 helix)
H: α-helix
I: 𝝅-helix (5 - turn helix)
T: Hydrogen Bonded Turn
B: β-sheet
S: Bend
C: Coil (residues not present in any of the above conformations)
N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications: