Modomics - A Database of RNA Modifications

ID Card:

Full name: 3-hydroxyacyl-CoA dehydrogenase type-2
Synonym: SDR5C1, ERAB, HADH2, MRPP2, SCHAD, XH98G2
GI: 2492759
COG: COG1028
UniProt: Q99714
Structures: | 1SO8 | 1U7T | 2O23 | 7ONU |
Alpha Fold Predicted Structure: AF-Q99714-F1
Complex: mtRNase P


PDB Structures:


1SO8

Structure Description:

Title:
Classification:
Technique:

Abstract of the PDB Structure's related Publication:

Mitochondrial dysfunction is a hallmark of beta-amyloid (Abeta)-induced neuronal toxicity in Alzheimer's disease (AD). Here, we demonstrate that Abeta-binding alcohol dehydrogenase (ABAD) is a direct molecular link from Abeta to mitochondrial toxicity. Abeta interacts with ABAD in the mitochondria of AD patients and transgenic mice. The crystal structure of Abeta-bound ABAD shows substantial deformation of the active site that prevents nicotinamide adenine dinucleotide (NAD) binding. An ABAD peptide specifically inhibits ABAD-Abeta interaction and suppresses Abeta-induced apoptosis and free-radical generation in neurons. Transgenic mice overexpressing ABAD in an Abeta-rich environment manifest exaggerated neuronal oxidative stress and impaired memory. These data suggest that the ABAD-Abeta interaction may be a therapeutic target in AD.

Download RCSB-PDB Structures:

Pdb Files   1SO8.pdb   1U7T.pdb   2O23.pdb   7ONU.pdb  
Pdbx/mmCIF Files   1SO8.cif   1U7T.cif   2O23.cif   7ONU.cif  


Protein sequence:

MAAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP

Comments:

Part of mitochondrial RNase P which consists of three proteins: MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391. All three are required for the enzyme endonuclease activity while two (MRPP1/TRMT10C, MRPP2/HSD17B10) are sufficient for methyltransferase activity (for more information see the entry for MRPP1/TRMT10C which is the catalytic compound in this complex).





Alpha Fold Predicted Structure:






Clear Selection and Reset Camera

Protein sequence:

M A A A C R S V K G L V A V I T G G A S G L G L A T A E R L V G Q G A S A V L L D L P N S G G E A Q A K K L G N N C V F A P A D V T S E K D V Q T A L A L A K G K F G R V D V A V N C A G I A V A S K T Y N L K K G Q T H T L E D F Q R V L D V N L M G T F N V I R L V A G E M G Q N E P D Q G G Q R G V I I N T A S V A A F E G Q V G Q A A Y S A S K G G I V G M T L P I A R D L A P I G I R V M T I A P G L F G T P L L T S L P E K V C N F L A S Q V P F P S R L G D P A E Y A H L V Q A I I E N P F L N G E V I R L D G A I R M Q P

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-Q99714-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-Q99714-F1.cif  
DSSP Secondary Structures   Q99714.dssp  





Publications:

Title Authors Journal Details PubMed Id DOI
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W... Nucleic Acids Res [details] 23042678 -

Links:

_PubMed_