ID Card:
Full name:
tRNA-specific adenosine deaminase 1
Synonym:
hADAT1
GI:
302058269
Orf:
ADAT1
UniProt:
Q9BUB4
Alpha Fold Predicted Structure:
AF-Q9BUB4-F1
Enzyme type:
deaminase
Position of modification - modification:
t :37 - m1I
Protein sequence:
MWTADEIAQLCYEHYGIRLPKKGKPEPNHEWTLLAAVVKIQSPADKACDTPDKPVQVTKEVVSMGTGTKCIGQSKMRKNGDILNDSHAEVIARRSFQRYLLHQLQLAATLKEDSIFVPGTQKGVWKLRRDLIFVFFSSHTPCGDASIIPMLEFEDQPCCPVFRNWAHNSSVEASSNLEAPGNERKCEDPDSPVTKKMRLEPGTAAREVTNGAAHHQSFGKQKSGPISPGIHSCDLTVEGLATVTRIAPGSAKVIDVYRTGAKCVPGEAGDSGKPGAAFHQVGLLRVKPGRGDRTRSMSCSDKMARWNVLGCQGALLMHLLEEPIYLSAVVIGKCPYSQEAMQRALIGRCQNVSALPKGFGVQELKILQSDLLFEQSRSAVQAKRADSPGRLVPCGAAISWSAVPEQPLDVTANGFPQGTTKKTIGSLQARSQISKVELFRSFQKLLSRIARDKWPHSLRVQKLDTYQEYKEAASSYQEAWSTLRKQVFGSWIRNPPDYHQFK
Comments:
Specifically deaminates adenosine 37 to inosine in exclusively cytoplasmic tRNA-Ala. The anticodon stem-loop of tRNAAla) alone is not a functional substrate for hADAT1.
Reaction
Substrate
SubstrateType
Position
(Anti)Codon
Modified (Anti)Codon
Amino Acid Change
Transcript Name
Transcript Region
Cellular Localization
References
A:I
tRNA (t)
Ala/IGC/unknown
37
IGC
IGC
tRNAAla IGC
anticodon-loop
10430867
Alpha Fold Predicted Structure:
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Protein sequence:
M
W
T
A
D
E
I
A
Q
L
C
Y
E
H
Y
G
I
R
L
P
K
K
G
K
P
E
P
N
H
E
W
T
L
L
A
A
V
V
K
I
Q
S
P
A
D
K
A
C
D
T
P
D
K
P
V
Q
V
T
K
E
V
V
S
M
G
T
G
T
K
C
I
G
Q
S
K
M
R
K
N
G
D
I
L
N
D
S
H
A
E
V
I
A
R
R
S
F
Q
R
Y
L
L
H
Q
L
Q
L
A
A
T
L
K
E
D
S
I
F
V
P
G
T
Q
K
G
V
W
K
L
R
R
D
L
I
F
V
F
F
S
S
H
T
P
C
G
D
A
S
I
I
P
M
L
E
F
E
D
Q
P
C
C
P
V
F
R
N
W
A
H
N
S
S
V
E
A
S
S
N
L
E
A
P
G
N
E
R
K
C
E
D
P
D
S
P
V
T
K
K
M
R
L
E
P
G
T
A
A
R
E
V
T
N
G
A
A
H
H
Q
S
F
G
K
Q
K
S
G
P
I
S
P
G
I
H
S
C
D
L
T
V
E
G
L
A
T
V
T
R
I
A
P
G
S
A
K
V
I
D
V
Y
R
T
G
A
K
C
V
P
G
E
A
G
D
S
G
K
P
G
A
A
F
H
Q
V
G
L
L
R
V
K
P
G
R
G
D
R
T
R
S
M
S
C
S
D
K
M
A
R
W
N
V
L
G
C
Q
G
A
L
L
M
H
L
L
E
E
P
I
Y
L
S
A
V
V
I
G
K
C
P
Y
S
Q
E
A
M
Q
R
A
L
I
G
R
C
Q
N
V
S
A
L
P
K
G
F
G
V
Q
E
L
K
I
L
Q
S
D
L
L
F
E
Q
S
R
S
A
V
Q
A
K
R
A
D
S
P
G
R
L
V
P
C
G
A
A
I
S
W
S
A
V
P
E
Q
P
L
D
V
T
A
N
G
F
P
Q
G
T
T
K
K
T
I
G
S
L
Q
A
R
S
Q
I
S
K
V
E
L
F
R
S
F
Q
K
L
L
S
R
I
A
R
D
K
W
P
H
S
L
R
V
Q
K
L
D
T
Y
Q
E
Y
K
E
A
A
S
S
Y
Q
E
A
W
S
T
L
R
K
Q
V
F
G
S
W
I
R
N
P
P
D
Y
H
Q
F
K
Secondary Structure Alphabet
G: 3-turn helix (310 helix) H: α-helix I: 𝝅-helix (5 - turn helix) T: Hydrogen Bonded Turn B: β-sheet S: Bend C: Coil (residues not present in any of the above conformations) N: Not assigned
Download PDB Structures & DSSP Secondary Structures:
Publications:
Title
Authors
Journal
Details
PubMed Id DOI
Identification and characterization of a human tRNA-specific adenosine deaminase related to the ADAR family of pre-mRNA editing enzymes.
Maas S, Gerber AP, Rich A...
Proc Natl Acad Sci U S A
[details]
10430867
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Links: