FBL (fibrillarin) is a catalytic subunit of a multiprotein C/D RNP complex and homologue of S. cerevisiae Nop1 protein. It requires snoRNA to identify the substrate. The core of the complex is made of 15.5kD, Nop56 and Nop58 proteins.
Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes.
Yanagida M, Hayano T, Yamauchi Y, Shinkawa T, Natsume T, Isobe T, Takahashi N
An intact Box C sequence in the U3 snRNA is required for binding of fibrillarin, the protein common to the major family of nucleolar snRNPs.
cDNA cloning and sequencing of human fibrillarin, a conserved nucleolar protein recognized by autoimmune antisera.
Evolutionary conservation of the human nucleolar protein fibrillarin and its functional expression in yeast.
Human fibrillarin forms a sub-complex with splicing factor 2-associated p32, protein arginine methyltransferases, and tubulins alpha 3 and beta 1 that is independent of its association with preribosomal ribonucleoprotein complexes.