Modomics - A Database of RNA Modifications

ID Card:

Full name: rRNA 2′-O-methyltransferase fibrillarin
Synonym: FIB1, FLRN, fibrillarin
GI: 12056465
COG: COG1889
UniProt: P22087
Structures: | 2IPX |
Alpha Fold Predicted Structure: AF-P22087-F1
Complex: C/D RNP
Enzyme type: methyltransferase
Position of modification - modification: many - Nm


PDB Structures:


2IPX

Structure Description:

Title: Human Fibrillarin
Classification: TRANSFERASE
Technique: X-Ray Diffraction
Resolution: 1.82
R value free: 0.246
R value observed: 0.202
R value work: 0.2

Abstract of the PDB Structure's related Publication:



Download RCSB-PDB Structures:

Pdb Files   2IPX.pdb  
Pdbx/mmCIF Files   2IPX.cif  


Protein sequence:

MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Comments:

FBL (fibrillarin) is a catalytic subunit of a multiprotein C/D RNP complex and homologue of S. cerevisiae Nop1 protein. It requires snoRNA to identify the substrate. The core of the complex is made of 15.5kD, Nop56 and Nop58 proteins.





Alpha Fold Predicted Structure:




Parsing response... [279872/279872]


Clear Selection and Reset Camera

Protein sequence:

M K P G F S P R G G G F G G R G G F G D R G G R G G R G G F G G G R G R G G G F R G R G R G G G G G G G G G G G G G R G G G G F H S G G N R G R G R G G K R G N Q S G K N V M V E P H R H E G V F I C R G K E D A L V T K N L V P G E S V Y G E K R V S I S E G D D K I E Y R A W N P F R S K L A A A I L G G V D Q I H I K P G A K V L Y L G A A S G T T V S H V S D I V G P D G L V Y A V E F S H R S G R D L I N L A K K R T N I I P V I E D A R H P H K Y R M L I A M V D V I F A D V A Q P D Q T R I V A L N A H T F L R N G G H F V I S I K A N C I D S T A S A E A V F A S E V K K M Q Q E N M K P Q E Q L T L E P Y E R D H A V V V G V Y R P P P K V K N
50100150200250300SequenceGHTSN

Secondary Structure Alphabet

  • G: 3-turn helix (310helix)
  • H: α-helix
  • I: 𝝅-helix (5 - turn helix)
  • T: Hydrogen Bonded Turn
  • B: β-sheet
  • S: Bend
  • C: Coil (residues not present in any of the above conformations)
  • N: Not assigned

Download PDB Structures & DSSP Secondary Structures:

Alpha Fold Pdb Files   AF-P22087-F1.pdb  
Alpha Fold Pdbx/mmCIF Files   AF-P22087-F1.cif  
DSSP Secondary Structures   P22087.dssp  





Diseases connected to this enzyme:

Publications:

Links:

_Wikipedia_
_PubMed_