ID Card:

Protein sequence:

Comments:

Hexose-transferase (Htr). Utilizes GDP-mannose, GDP-galactose In tRNAAsp (anticodon QUC) and tRNATyr (anticodon QYA) from certain eukaryotic cells (e.g. mammalian hepatocytes), the nucleoside Q-34 is further hypermodified into a glycosylated derivative by tRNA-queuine glycosyltransferase. This enzymatic activity was detected in rat liver extract and Xenopus leavis oocytes but the protein was not purified.

Reaction	Substrate	SubstrateType	Position	(Anti)Codon	Modified (Anti)Codon	Amino Acid Change	Transcript Name	Transcript Region	Cellular Localization	References
Q:galQ	tRNA (t)	Tyr/GUA/prokaryotic cytosol	34
Q:manQ	tRNA (t)	Asp/GUC/prokaryotic cytosol	34

Publications:

Title	Authors	Journal	Details	PubMed Id	DOI
The RNA Modification Database: 1999 update.	Rozenski J, Crain PF, McCloskey JA	Nucleic Acids Res	[details]	9847178	-
Enzymatic formation of queuosine and of glycosyl queuosine in yeast tRNAs microinjected into Xenopus laevis oocytes. The effect of the anticodon loop sequence.	Haumont E, Droogmans L, Grosjean H	Eur J Biochem	[details]	3117541	-
Structure, biosynthesis, and function of queuosine in transfer RNA.	Nishimura S	Prog Nucleic Acid Res Mol Biol	[details]	6410456	-
Enzymatic synthesis of Q nucleoside containing mannose in the anticodon of tRNA: isolation of a novel mannosyltransferase from a cell-free extract of rat liver.	Okada N, Nishimura S	Nucleic Acids Res	[details]	20603	-