Modomics - A Database of RNA Modifications


NameAmiothrophic Lateral Sclerosis (A:I)
DescriptionDefect in the editing of the messenger RNA encoding the GluR2 subunit of glutamate AMPA receptors in ALS patients
Related RNA reactionA:I
Found in RNAmRNA
Modified TranscriptGRIA2
Mapping TechnologyRT-PCR
Quantification techniquesRT-PCR, Restriction Digestion

Enzymes connected to Amiothrophic Lateral Sclerosis:

Acronym Full name Enzyme Role Organism Comment
ADARB1 Double-stranded RNA-specific editase 1 None Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1402 Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis H Takuma 1999-02-01 [details] 10589532 10.1002/1531-8249(199912)46:6<806::aid-ana2>;2-s