| Name | Melanoma (A:m6A) |
| Description | Increased m6A methylation level (due to METTL3 upregulation) promotes melanoma cell lines colony formation and invasion. MMP2 and N-cadherin play a crucial role in invasion and metastasis of melanoma cells and their expression was found to be associated to METTL3 upregulation. These results indicate that METTL3 may regulate MMP2 and N-cadherin. Whereas MMP2 expression depends on the catalytic activity of METTL3, regulation of N-cadherin appears to be independent of METTL3 catalytic activity. |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | MMP2,N-cadherin |
| Mapping Technology | |
| Quantification techniques | m6A dot blot assay |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| METTL3 | N6-adenosine-methyltransferase 70 kDa subunit | oncogene | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1076 | RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrixmetallopeptidase 2. | Dahal U, Le K, Gupta M | Melanoma Res | [details] | 30762711 | 10.1097/CMR.0000000000000580 |