Modomics - A Database of RNA Modifications


NameDepression disorder (A:I)
DescriptionRNA editing inhibits the enzymatic activity of TPH2 splice variants. Deregulated alternative splicing and RNA editing are involved in the etiology of psychiatric diseases, such as suicidal behavior.
Related RNA reactionA:I
Found in RNAmRNA
Modified TranscriptTPH2b
Mapping Technologyexone sequencing
Quantification techniquesHPLC

Enzymes connected to Depression disorder:


Acronym Full name Enzyme Role Organism Comment
Exact modification enzyme yet to be verified. One or more ADAR enzymes involved, putatively.  
ID Title Authors Journal Details PubMed Id DOI
1008 Alternative splicing and extensive RNA editing of human TPH2 transcripts. Maik Grohmann PLoS One [details] 20126463 10.1371/journal.pone.0008956