| Name | Malignant pleural mesothelioma (A:m6A) |
| Description | The association between MPM and asbestos exposure is established but the mechanism is unclear. It was proposed that asbestos causes DNA damage by inducing DNA alkylation and methylation. Thus, methylation could be at the bases of the MPM onset and the characterized FTO rs9939609 polymorphism which alters its expression level, may play a role in asbestos-induced methylation and carcinogenesis |
| Related RNA reaction | A:m6A |
| Found in RNA | mRNA |
| Modified Transcript | None |
| Mapping Technology | None |
| Quantification techniques | None |
| Acronym | Full name | Enzyme Role | Organism | Comment |
|---|---|---|---|---|
| FTO | Alpha-ketoglutarate-dependent dioxygenase FTO | None | Homo sapiens |
| ID | Title | Authors | Journal | Details | ||
|---|---|---|---|---|---|---|
| 1074 | The Association Between the FTO rs9939609 Variant and Malignant Pleural Mesothelioma Risk: A Case-Control Study. | Mina S Khella | Genet Test Mol Biomarkers | [details] | 29260910 | 10.1089/gtmb.2017.0146 |