We currently offer the following position in the Bujnicki group in IIMCB, Warsaw, Poland
 

  1. Ph.D. Student Position experimental determination of RNA-protein complex structures
  2. Ph.D. Student Position software development, bioinformatics, molecular simulations and modeling
  3. Research Technician Position biochemistry and structural biology of RNA-ligand interactions

 

red - jobs focused on software development (with some molecular modeling)
orange - jobs focused on modeling and data analyses (with some software development)
green - jobs focused on experimental biochemistry and biophysics

 

 



 

Ph.D. Student Position experimental determination of RNA-protein complex structures

 
 
Deadline for applications is April 15 2019. Preferred job starting date is May , 2019.
 
Project description: Ribonucleic acid (RNA) molecules and their complexes with proteins (RNPs) play pivotal roles in living organisms. A very large fraction of biological processes, including the key aspects of genetic information processing, such as the regulation of gene expression, maturation of transcripts, and protein synthesis, rely on a concerted action of macromolecular complexes composed of protein and RNA molecules. The goal of the project is study the mechanism of action of RNPs, solve their 3D structures and to understand how the interaction between the RNA and protein influence the functions performed by them. Experimental analyses will be combined with computational modeling, to determine structures for macromolecular complexes. As a Ph.D. student, you will be involved in experimental analyses of RNA, protein, and RNP 3D structures, including structure determination with a variety of biochemical and biophysical techniques, e.g., crystallography, SAXS, AFM, cryoEM. You will collaborate with other researchers (theoreticians and experimentalists) within the team, in the institute, as well as with international partners. This project is for junior scientists interested in studying structures of biological macromolecules with various experimental methods and in interdisciplinary work that involves computational modeling based on experimental data.
 
Required for this position:
  • MSc degree (or other equivalent master’s degree) in biology, chemistry or related area - defended before the start of the work on the project and the first year of PhD studies.
  • Eligibility for PhD studies in Poland under the supervision of prof. Bujnicki.
  • Documented experience in biochemical and biophysical analyses of protein and nucleic acid structures. Experience in macromolecular crystallography, SAXS, AFM, cryoEM, biochemical probing of RNA structure and other related techniques will be advantageous.
  • A proactive approach to achieving tasks and objectives, good interpersonal skills, a collaborative attitude.
  • Have very good written and oral communication in English. 
  • Enjoy working in a highly collaborative and interdisciplinary environment
 
Desired, but not essential expertise
  • Experience in bioinformatics, molecular modeling, and data analysis.
 
Priority will be for candidates with expertise most relevant to the project and to the profile of the laboratory, who are familiar with our work (in particular with our publications related to the topic of this project) and who can convincingly explain why their expertise is a good fit for our requirements.
 
We offer:
    • Full-time Ph.D. scholarship of 4000 PLN/month
    • Position with 100% focus on research (no teaching obligations)
    • Scientific mentoring, including the supervision of an individual Thesis Advisory Committee
    • Participation in courses, scientific training, support from peers
    • Benefits including reduced-rate for a medical care package and membership in the MultiSport program 
    • Technical, administrative, and organizational support from professional English-speaking personnel 
 
The funding for the Ph.D. project is provided by a grant entitled “Integrative modeling and structure determination of RNA-protein complexes", which is carried out as the MAESTRO 2017/26/A/NZ1/01083 grant of the Polish National Science Center.
 
Ph.D. studies: Our Ph.D. students are enrolled in Ph.D. schools on the campus, in particular at the collaborating institutes of the Polish Academy of Sciences. Ph.D. students have an opportunity to participate in a hands-on training program, covering theoretical and practical aspects of molecular biology, biochemistry, biophysics of proteins and nucleic acids, structural biology, and bioinformatics. Students-programmers are trained in software development. Ph.D. studies involve a full-time research project in one or more of the areas mentioned above, combined with training in soft skills (e.g., presenting scientific results, writing publications and grant applications, managing projects). 
 
How to apply: 
  • Apply now (before the deadline of April 15th, 2019) to employment@genesilico.pl 
  • In the subject, include "PhDstudent_RNPStructure" and your first and last name.
  • Your application must be submitted in English and should contain:  
    • a CV
    • a cover letter including a short description of your key achievements and explicit responses to the following questions: 
      • What are your scientific interests and how do they relate to requirements of the position offered? 
      • What are your key strengths? What do you know about our laboratory and why do you want to work with us?
    •  contacts to at least two potential referees, including your M.Sc. supervisor
  • Please include the following statement in your application: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://www.iimcb.gov.pl/pl/information-clause
  • The competition may be extended or repeated until a suitable candidate who fulfills all requirements is found
 
 The PhD student will be selected from candidates in an open competition, according to the procedure complying the rules for granting scholarships for young scientists in research projects funded by the National Science Centre (NCN Council Resolution No. 96/2016 dated October 27, 2016 r.)  and the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part  of HR Excellence in Research strategy https://www.iimcb.gov.pl/en/institute/hr-excellence

 

 


 

Ph.D. Student Position software development, bioinformatics, molecular simulations and modeling

 

Deadline for applications is April 22th, 2019. Preferred job starting date: no later than June 1st, 2019.

Project description: The project “A coarse-grained method for RNA 3D structure modeling, with emphasis on non-canonical base pairing" (PI: dr. Michal Boniecki) is carried out as the OPUS 2016/23/B/ST6/03433 grant of the Polish National Science Center. The PhD student will be selected from candidates in an open competition, according to the procedure complying the rules for granting scholarships for young scientists in research projects funded by the National Science Centre (NCN Council Resolution No. 96/2016 dated. October 27, 2016 r.). The goal of the project is to further develop SimRNA, which is now one of the best methods for 3D RNA structure prediction and simulations, in the field. We intend to improve the prediction of non-canonical base-pairs, and to improve the overall specificity. Additional tasks include RNA 3D structure prediction with additional restraints and setting up a web server. We provide opportunities for interdisciplinary collaborations within the team, in the institute, as well as with international partners.

Required for this position:

  • M.Sc. (or equivalent) in computer science, physics, molecular biology, chemistry or related area (defended before the start of the work on the project)
  • Basic knowledge in the fields of physics, mathematics, computer science
  • Understanding the basic concepts of physics, including interaction, dynamics, thermodynamics 
  • Understanding issues of 3D geometry, derivation of statistical potentials, running simulations, working in Linux
  • Eligibility for PhD studies in Poland
  • Documented experience in programming/designing in C/C++ and/or Python
  • Proactive approach to achieving tasks and objectives, good interpersonal skills, collaborative attitude
  • Experience in bioinformatics, molecular modeling etc. is advantageous, but not essential. 

Priority will be given to candidates with expertise most relevant to the project and to the profile of the laboratory, who are familiar with our work (e.g., our publications and our software) and who can convincingly explain why their expertise is a good fit for our requirements.

We offer:

  • Full-time Ph.D. scholarship PhD fellowship 3000 PLN/month 
  • Position with 100% focus on research (no teaching obligations)
  • Participation in courses, scientific training, support from peers, and academic mentoring
  • Scientific mentoring, including the supervision of an individual Thesis Advisory Committee
  • Technical, administrative, and organizational support from professional English-speaking personnel 
  • Benefits including reduced-rate for an individual medical care package and membership in MultiSport programme

The funding of the Ph.D. project is provided by a grant entitled “A coarse-grained method for RNA 3D structure modeling, with emphasis on non-canonical base pairing", carried out as the OPUS 2016/23/B/ST6/03433 grant of the Polish National Science Center (NCN). 


Ph.D. studies: Our Ph.D. students are enrolled in Ph.D. schools on the campus, in particular at the collaborating institutes of the Polish Academy of Sciences. Ph.D. students have an opportunity to participate in a hands-on training program, covering theoretical and practical aspects of molecular biology, biochemistry, biophysics of proteins and nucleic acids, structural biology, and bioinformatics. Students-programmers are trained in software development. Ph.D. studies involve a full-time research project in one or more of the areas mentioned above, combined with training in soft skills (e.g., presenting scientific results, writing publications and grant applications, managing projects). 

How to apply: 

  • Apply now to recruitment@iimcb.gov.pl
  • In the subject include "PhD-SimRNA-devel" and your first and last name.
  • Your application must be submitted in English and should contain:
    • a CV
    • a cover letter including  a short description of your key achievements and explicit responses to the following questions: 
      • What are your scientific interests and how do they relate to requirements of the position offered? 
      • What are your key strengths? What do you know about our laboratory and why do you want to work with us?
    • contacts to at least two potential referees, including your M.Sc. supervisor 
  • Please include the following statement in your application: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying  out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw.  Full information is available under the link https://www.iimcb.gov.pl/pl/information-clause
  • The competition may be extended or repeated until a suitable candidate who fulfills all requirements is found

The Ph.D. student will be selected from candidates in an open competition, according to the procedure complying the rules for granting scholarships for young scientists in research projects funded by the National Science Centre  (NCN Council Resolution No. 96/2016 dated October 27, 2016 r.)  and to the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://www.iimcb.gov.pl/en/institute/hr-excellence

 

 


Research Technician Position biochemistry and structural biology of RNA-ligand interactions
 

Deadline for applications is May 15th, 2019. Preferred job starting date is June 1st, 2019 (as soon as possible).

Project description: Ribonucleic acid (RNA) molecules play pivotal roles in living organisms. Their functions are often modulated by interactions with other molecules. Examples of RNA molecules regulated by small chemical molecules include riboswitches in bacteria and regulatory elements in viruses. The goal of this project (funded by the FNP “TEAM” grant) is to study the mechanism of action of shape-shifting RNAs, solve their 3D structures, and understand how the interactions with small molecule ligands influence their function. Ultimately, we will identify small chemical molecules that can block the function of regulatory RNAs and can serve as a starting point for the development of antibacterial and antiviral drugs. As a Research Technician, you will be fully involved in research activities, from experiment design to the interpretation of results, and co-authoring scientific publications. You will be expected to master a wide range of techniques including RNA expression and purification, structural analyses (such as biochemical probing, X-ray crystallography and structure analyses in solution), and analyzing RNA-ligand interactions with various biochemical and biophysical techniques. You will also be involved in various house-keeping activities (including ordering supplies, maintaining stocks, taking care of documentation, etc.) and in the training of junior scientists.

The institution: International Institute of Molecular and Cell Biology in Warsaw www.iimcb.gov.pl is one of the top-ranked (A+) Polish research institutes, which provides a stimulating and interdisciplinary research environment. Research topics at IIMCB cover the wide area of molecular, cellular, and structural biology. The Institute is equipped with state-of-the-art technology, has excellent core facilities and supportive administration. IIMCB benefits from numerous generous funding schemes for basic research through grants from international and national sources. The institute is located in a large biomedical campus that offers access to equipment and various possibilities of training and collaboration. The working language of the institute is English. 

The team: Our group http://genesilico.pl is highly interdisciplinary and international. We combine various approaches for studying the structures and mechanisms of action of biological macromolecules, in particular RNA, as well as macromolecular complexes involving nucleic acids, proteins, and small molecules. Our key strength is in the integration of various types of theoretical and experimental analyses.  On the one hand, we use biochemical and biophysical approaches to characterize the structures and functions of our target molecules experimentally. On the other hand, we develop and use computer programs for data analyses, in particular for modeling based on heterogeneous, low-resolution, and noisy experimental data. We also use theoretical predictions to guide knowledge-based design and engineering of molecules with new structures and functions. 
  
This position is ideal for individuals who enjoy learning and implementing new methods, have excellent self- and time management skills, and who are comfortable with multitasking and being involved in multiple analyses in parallel. Researchers who love contributing to teamwork, can combine precision and fast work, have excellent communication skills, and are highly adaptive, will have many prospects to make it a big success. The TEAM project provides opportunities for extensive interdisciplinary collaborations within the team and in the institute (e.g., with software developers, molecular modelers, and experimentalists), as well as international collaborations with academia and industry. You will have access to modern equipment and support from other experienced researchers. 

We offer:
    • Full-time contract (“umowa o pracę”), funded from the TEAM grant initially until 30/09/2020, with intended extension beyond this project
    • 8000 PLN of full remuneration cost, i.e., expected net salary at ~4500 PLN/month, with social security
    • Benefits including reduced-rate for an individual medical care package and membership in the MultiSport program 
    • Administrative and organizational support from professional English-speaking personnel 


We require from candidates for this position:

  • M.Sc. or Ph.D. in biochemistry, molecular biology or related discipline 
  •  Documented extensive experience in biochemical/biophysical analyses of biomacromolecules, in particular in studies of macromolecule-ligand interactions or in macromolecular structural biology
  • Expertise and technical competence in designing and carrying out scientific experiments and in interpreting their results
  • Proactive approach to achieving objectives, good interpersonal skills, collaborative attitude
  • Very good command of English (written and oral communication)
  • Good command of Polish will be advantageous, but it is not required. Candidates who do not speak Polish will be expected to learn it to the level necessary to communicate with Polish sale representatives

Priority will be given to candidates with expertise most relevant to the project and to the profile of the laboratory, who are familiar with our work and who can convincingly explain why their expertise is a good fit for our requirements.

The Research Technician will be selected from candidates in an open competition, according to the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://www.iimcb.gov.pl/en/institute/hr-excellence 

How to apply: 

  • Apply now (before the deadline of May 15th, 2019) to employment@genesilico.pl
  • In the subject include "TEAM-technician" and your first and last name.
  • Your application must be submitted in English and should contain: 1) a CV, 2) a cover letter including a short description of your key achievements and explicit responses to the following questions: What are your scientific interests and how do they relate to requirements of the position offered? What are your key strengths? What do you know about our laboratory and why do you want to work with us?, 3) contacts to at least two potential referees, including your M.Sc. (or Ph.D.) supervisor. At this stage, please do not attach copies of diplomas, etc. 
  • Please include the following statement in your application: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying  out the current recruitment process.” Your personal data will be processed for the purpose of the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://www.iimcb.gov.pl/pl/information-clause
  • The competition may be extended or repeated until a suitable candidate who fulfills all requirements is found.

 

Frequently asked questions:

 
Q: Is health insurance provided?
A: For postdoctoral and technician positions associated with a full work contract ("umowa o pracę"), full health insurance and social security (ZUS) is included. For undergraduate and gratuate students, and for volunteers, basic health insurance is provided, and if they wish, they may insure themselves individually to make their contribution to ZUS.
 
Q: Are references required?
A: Yes, references are an important part of the selection process and candidates for postdoctoral positions are asked to provide at least two names of referees (one name for students), including at least one former or current supervisor.
 
Q: I am not from Poland and I don't speak Polish. Am I eligible to apply?
A: Yes, IIMCB welcomes applications from outside Poland. IIMCB has an international culture, and the official working language is English.