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Laboratory of Bioinformatics and Protein Engineering at the International Institute of Molecular and Cell Biology (IIMCB), Warsaw, headed by Prof. Janusz M. Bujnicki, offers a position for a

 

Postdoctoral researcher

in software development and modeling of RNA and RNP 3D structure

 

Deadline for applications: July 31st , 2022. Preferred job starting date: September 1st, 2022 or as soon as possible

 

As a Postdoctoral Researcher, you will play a leading role in the development of innovative integrative software for computational determination and modeling of macromolecular structures of RNA and proteins. In particular, you will be involved in the further development of our very successful SimRNA and SimRNP methods for the modeling of RNA and RNP structures, both in purely theoretical simulations and with data from various experiments, especially CryoEM, SAXS and chemical probing. You will also be involved in structure determination and modeling analyses for various human, viral, and bacterial RNAs and RNA-protein complexes studied experimentally in the laboratory.

 

This position is ideal for you if you have solid experience in software development (in particular in C/C++) and in macromolecular modeling (in particular Monte Carlo and/or Molecular Dynamics simulations), and if you wish to learn new techniques of integrative structural biology, including experimental research and computational modeling. You have to be a skilled programmer already at the beginning of the project, so you can read and modify the existing advanced code, under supervision of other programmers who have experience with that code. This position is not for beginners who want to start learning software development, but for good programmers motivated to further develop their skills

 

We encourage applications from candidates at any stage of their post-doctoral career, in particular from those interested in submitting their own fellowship/grant applications and in training towards scientific independence (next stage: senior postdoc or junior group leader elsewhere) or growing towards a position of a senior scientist within our organization (long-term cooperation, involvement in multiple projects, supervision of junior scientists).
You are expected to take a lead and apply for fellowship/grant funding within the first 15 months of your employment, with a project that combines the area of our interest with your own ideas.

 

Our laboratory http://iimcb.genesilico.pl studies the structures and mechanisms of biological macromolecules, in particular RNA and macromolecular complexes involving nucleic acids, proteins, and small molecules. We use experimental approaches such as chemical probing, crystallography, cryo-EM, and SAXS to characterize the structures and functions of RNAs and their complexes. We also develop and use computer programs for data analyses, in particular for modeling based on experimental data. Examples of our methods include SimRNA and ModeRNA, and the MODOMICS database. Our recent analyses include the 3D structure modeling of the SARS-CoV-2 coronavirus RNA.

 

The Institute www.iimcb.gov.pl is equipped with state-of-the-art technology, has excellent core facilities and supportive administration. IIMCB benefits from numerous generous funding schemes for basic research through grants from international and national sources. The institute is located in a large biomedical campus that offers access to equipment and various possibilities of training and collaboration. We provide opportunities for extensive interdisciplinary collaborations within the team and in the institute, as well as external and international collaborations. The working language of the institute is English.

 

We offer:

• Full-time contract (“umowa o pracę”) for at least 15 months, with an intended extension depending on performance

•  Gross monthly remuneration starting at 7500 PLN/month, net approx. 6000 PLN/month, commensurate with experience (the final monthly gross salary will be calculated individually during the employment process, taking into account the length of service). Additional bonuses such as the 13th salary after working for the Institute for six months in a given calendar year, or Christmas bonus may supplement this salary.

• Benefits including reduced-rate for an individual medical care package and membership in the MultiSport program

• Work in a multidisciplinary, international team, in a very dynamic organization, with multiple opportunities for professional development, participation in courses, scientific training, support from peers, and academic mentoring

• Administrative and organizational support from professional English-speaking personnel

 

We require:

• Ph.D. in any relevant area (e.g., physics, biology, chemistry, etc.)

• Strong publication record, including at least one first-author publication in a very good journal

• Documented experience in molecular simulations

• Documented experience in programming (C/C++ or Python and ideally both)

• Experience in structural bioinformatics is not essential, but will be a strong advantage

• Experience in machine learning is not essential, but will be a strong advantage

• Experience in RNA bioinformatics and RNA structure analysis is not essential, but will be a strong advantage

• Expertise and competence in designing and carrying out computational analyses of complex datasets and in interpreting their results

• Experience in writing manuscripts for publication, and fellowship or grant proposals

• Vision of your professional growth within ~5 years, including the capacity to apply for fellowship/grant funding within the first year of your employment, with projects that synergize the core strengths of the team with your own ideas

• approach to achieving objectives, good interpersonal skills, collaborative and adaptive attitude

• Very good organizational skills, especially project and time management skills

• Very good command of English (written and oral communication) and presentation skills

 

How to apply:

• Email your application to recruitment@iimcb.gov.pl

• In the subject of the message include "IIMCB-postdoc-RNAmodeling-softdev" and your first and last name

• application must be submitted in English and should contain: 1) a CV, 2) a cover letter including a short description of key achievements and explicit responses to the following questions: What are scientific interests and how do they relate to requirements of the position offered? What are key strengths? What do know about our laboratory, why do want to work with us, what would you like to learn while working with us?,
3) contacts to at least two potential referees, including Ph.D. . At this stage, please do not attach copies of diplomas, .

• Please include the following statement in CV: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” data will the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://bit.ly/3guEMJ7

• We will contact only selected best candidates, who may be given additional questions and tasks as a part of the recruitment process

• The competition may be extended or repeated until a suitable candidate who fulfills all requirements is found

 

The Postdoctoral Researcher will be selected from candidates in an open competition, according to the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://bit.ly/35tXdaq .

 

This position is offered within a project entitled “Integrative modeling and structure determination of RNA-protein complexes” carried out as the MAESTRO grant of the Polish National Science Centre (UMO-2017/26/A/NZ1/01083).

 

 

Postdoctoral researcher

in molecular and structural biology of RNA: focus on RNA modifications

 

Deadline for applications: July 31th, 2022. Preferred job starting date: September 1st, 2022 or as soon as possible

 

As a Postdoctoral Researcher, you will be involved in interdisciplinary experimental analyses of RNA structure focused on mechanistic, structure-level understanding of how posttranscriptional modifications influence RNA folding, its ability to form alternative 3D structures, and interactions with other molecules.

 

This position is ideal for you if you have solid experience in experimental analyses of RNA structure and interactions, and/or detection and characterization of RNA modifications, and if you wish to learn new techniques of integrative structural biology, including experimental research and computational modeling.

 

Our laboratory http://iimcb.genesilico.pl studies the structures and mechanisms of biological macromolecules, in particular RNA and macromolecular complexes involving nucleic acids, proteins, and small molecules. We use experimental approaches such as chemical probing, crystallography, cryo-EM, and SAXS to characterize the structures and functions of RNAs and their complexes. We also develop and use computer programs for data analyses, in particular for modeling based on experimental data. Examples of our methods include SimRNA and ModeRNA, and the MODOMICS database. Our recent analyses include the 3D structure modeling of the SARS-CoV-2 coronavirus RNA.

 

The Institute www.iimcb.gov.pl is equipped with state-of-the-art technology, has excellent core facilities and supportive administration. IIMCB benefits from numerous generous funding schemes for basic research through grants from international and national sources. The institute is located in a large biomedical campus that offers access to equipment and various possibilities of training and collaboration. We provide opportunities for extensive interdisciplinary collaborations within the team and in the institute, as well as external and international collaborations. The working language of the institute is English.

We offer:

• Full-time contract (“umowa o pracę”) for 36 months

• Gross monthly remuneration: 7350 PLN/month - 7600 PLN/month, net approx. 5800 PLN/month - 6000 PLN/month (the final monthly gross salary will be calculated individually during the employment process, taking into account the length of service). Additional bonuses such as the 13th salary after working for the Institute for six months in a given calendar year, or Christmas bonus may supplement this salary.

• Benefits including reduced-rate for an individual medical care package and membership in the MultiSport program

• Work in a multidisciplinary, international team, in a very dynamic organization, with multiple opportunities for professional development, participation in courses, scientific training, support from peers, and academic mentoring

• Administrative and organizational support from professional English-speaking personnel

 

We require:

• Ph.D. in any relevant area (e.g., biology, chemistry, etc.), defended no more than 7 years before the start of the contract (according to the rules of the funding agency)

• Fulfillment of formal criteria of the competition in particular section 2.1.1: https://bit.ly/3cLloW0

• Significant background in RNA biochemistry and molecular biology, including RNA sequencing by NGS-based methods and at least one of the following techniques: 1) experimental detection of modified residues in RNA, 2) RNA structure analysis by chemical or enzymatic probing, 3) analyses of macromolecular interactions by spectroscopic techniques and calorimetry, 4) macromolecular crystallization and X-ray crystallography,

• Expertise and competence in designing and carrying out scientific experiments and in interpreting their results

• Experience in writing manuscripts for publication and in scientific presentations

• approach to achieving objectives, good interpersonal skills, collaborative and adaptive attitude

• Very good organizational skills, especially project and time management skills

• Very good command of English (written and oral communication) and presentation skills

 

How to apply:

• Email your application to recruitment@iimcb.gov.pl

• In the subject of the message include " IIMCB-postdoc-RNAmods-structure" and your first and last name

• application must be submitted in English and should contain: 1) a CV, 2) a cover letter including a short description of key achievements and explicit responses to the following questions: What are scientific interests and how do they relate to requirements of the position offered? What are key strengths? What do know about our laboratory and why do want to work with us?, 3) contacts to at least two potential referees, including Ph.D. . At this stage, please do not attach copies of diplomas, .

• Please include the following statement in CV: “I hereby agree to the processing of my personal data, included in the application documents by the International Institute of Molecular and Cell Biology in Warsaw, 4 Księcia Trojdena Street, 02-109 Warsaw, for the purpose of carrying out the current recruitment process.” data will the recruitment procedure by the International Institute of Molecular and Cell Biology in Warsaw. Full information is available under the link https://bit.ly/3guEMJ7

• We will contact only selected best candidates, who may be given additional questions and tasks as a part of the recruitment process

• The competition may be extended or repeated until a suitable candidate who fulfills all requirements is found

 

The Postdoctoral Researcher will be selected from candidates in an open competition, according to the procedure complying with the rules of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers as a part of HR Excellence in Research strategy https://bit.ly/35tXdaq.

 

This position is offered within a project entitled “Unraveling the influence of posttranscriptional modifications on RNA 3D structure formation and its dynamics, with the integrated use of theoretical and experimental approaches” carried out as the OPUS grant of the Polish National Science Centre (UMO-2020/37/B/NZ2/02456).