Fluostatins I-K from the South China Sea-derived micromonospora rosaria SCSIO N160
Overview of Zhang W et al.
| Authors | Zhang W Liu Z Li S Lu Y Chen Y Zhang H Zhang G Zhu Y Zhang G Zhang W Liu J Zhang C |
|---|---|
| Affiliation | CAS Key Laboratory of Marine Bio-resources Sustainable Utilization RNAM Center for Marine Microbiology Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences 164 West Xingang Road Guangzhou 510301 People's Republic of China. |
| Journal | J Nat Prod |
| Year | 2012 |
Abstract
The strain SCSIO N160 was isolated from a South China Sea sediment sample and was characterized as a Micromonospora rosaria species on the basis of its 16S rRNA gene sequence. Three new fluostatins, I-K (1-3), were isolated from the culture of M. rosaria SCSIO N160, together with six known compounds, fluostatins C-F (4-7), rabelomycin (8), and phenanthroviridone (9). The structure of fluostatin D (5) was confirmed by an X-ray crystallographic study. The absolute configuration of 1 and 3 was assigned by electronic circular dichroism calculations. Compounds 8 and 9 exhibited good antimicrobial activities against Staphylococcus aureus ATCC 29213 with MIC values of 1.0 and 0.25 μg/mL, respectively. Compound 9 also exhibited significant in vitro cytotoxic activities toward SF-268 (IC50 0.09 μM) and MCF-7 (IC50 0.17 μM).