Two new neutral copper(II) complexes with dipicolinic acid and 3-amino-1H-1,2,4-triazole formed under different reaction conditions: synthesis, characterization, molecular structures and DNA-binding studies
Overview of Tabatabaee M et al.
| Authors | Tabatabaee M Bordbar M Ghassemzadeh M Tahriri M Tahrir M Mehri Lighvan Z Neumüller B |
|---|---|
| Affiliation | Department of Chemistry Yaz Branch Islamic Azad University Yazd Iran. Electronic address: tabatabaee45@gmail.com. |
| Journal | Eur J Med Chem |
| Year | 2013 |
Abstract
Two Cu(II) complexes, [Cu₂(μ-atr)(pydc)₂(H₂O)₄]·5H₂O (1) and [Cu(atr)(pydc) (H₂O)]·H₂O (2), with pyridine-2,6-dicarboxylic acid (H₂pydc) and 3-amino-1H-1,2,4-triazole (atr), have been synthesized and characterized. The interaction ability of the both complexes with native calf thymus DNA (CT-DNA) has been monitored as a function of the metal complex-DNA molar ratio. UV-vis spectrophotometry, circular dichroism (CD), thermal denaturation studies, cyclic voltammetry (CV) and viscosity measurements. The intrinsic binding constants K(b) of complexes 1 and 2, with CT-DNA obtained from UV-vis absorption studies were 4.7 (±0. 1) × 10(4) and 9.5 (±0. 1) × 10(4) M(-1), respectively. Further investigation of interaction mode was performed using viscosity, cyclic voltammetry and T(m) of CT-DNA studies as well as CD study, indicating complexes bind to DNA via an intercalation mode.