Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies
Overview of Chen ZF et al.
| Authors | Chen ZF Liu YC Liu LM Wang HS Qin SH Wang BL Bian HD Yang B Fun HK Liu HG Liang H Orvig C |
|---|---|
| Affiliation | The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education) School of Chemistry & Chemical Engineering of Guangxi Normal University Guilin 541004 P. R. China. chenzfubc@yahoo.com |
| Journal | Dalton Trans |
| Year | 2008 |
Abstract
Liriodenine (), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (), cis-[PtCl2(L)(DMSO)] (), and cis-[RuCl2(L)(DMSO)2].1.5H2O (), the crystal structures of , and were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, 1H and 13C NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of and complexes against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free , suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of and its complexes to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.