A positively charged trinuclear 3N-chelated monofunctional platinum complex with high DNA affinity and potent cytotoxicity
Overview of Zhao Y et al.
| Authors | Zhao Y He W Shi P Zhu J Qiu L Lin L Guo Z |
|---|---|
| Affiliation | State Key Laboratory of Coordination Chemistry Coordination Chemistry Institute School of Chemistry and Chemical Engineering Nanjing University Nanjing 210093 P R China. |
| Journal | Dalton Trans |
| Year | 2006 |
Abstract
A trinuclear 3N-chelated monofunctional platinum complex, [Pt3(HPTAB)Cl3](ClO4)3 (HPTAB = N,N,N',N',N'',N''-hexakis(2-pyridylmethyl)-1,3,5-tris(aminomethyl)benzene), has been structurally characterized, which binds to DNA and demonstrates much higher potency against the murine leukemia cell line (P-388) and the human nonsmall-cell lung cancer cell line (A-549) than cisplatin.