Modomics - A Database of RNA Modifications

Reaction details:

Reaction type level 1: demethylation
Reaction type level 2: dealkylation
Reaction type level 3: group removal
Input group: *C
Output group: *H
Introduced group name: hydrogen
Introduced group type: hydrogen
Site: base/exocyclic
Atom address: N6
Modification level: 0

Enzymes that catalyse this reaction:

Acronym Full name Organism
ALKBH5 RNA demethylase ALKBH5 Homo sapiens
FTO Alpha-ketoglutarate-dependent dioxygenase FTO Homo sapiens
 

Image with reaction


Image with reaction

Image with reaction

Publications

Title Authors Journal Details PubMed Id DOI
ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility. Zheng G, Dahl JA, Niu Y, Fedorcsak P, Huang CM, Li CJ, Vagbo CB, Shi Y, Wang WL, Song SH, Lu Z, Bosmans RP, Dai Q, Hao YJ, Yang X, Zhao WM, Tong WM, Wang XJ, Bogdan F, Furu K, Fu Y, Jia G, Zhao X, Liu J, Krokan HE, Klungland A, Yang YG, He C... Mol Cell [details] 23177736 -