Modomics - A Database of RNA Modifications


NameType 2 Diabetes (A:m6A)
DescriptionMETTL3 and METTL14 protein levels are decreased in whole islets from T2D patients. the Insulin/IGF1 -AKT-PDX1 pathway is significantly affected by hypomethylation in T2D
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptInsulin/IGF1 -AKT-PDX1 pathway
Mapping TechnologyMeRIP-seq
Quantification techniquesLC-MS/MS

Enzymes connected to Type 2 Diabetes:

Acronym Full name Enzyme Role Organism Comment
METTL14 N6-adenosine-methyltransferase non-catalytic subunit Homo sapiens
METTL3 N6-adenosine-methyltransferase 70 kDa subunit Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1124 mA mRNA Methylation Regulates Human β-Cell Biology in Physiological States and in Type 2 Diabetes. Dario F De Jesus Nat Metab [details] 31867565 10.1038/s42255-019-0089-9