Modomics - A Database of RNA Modifications


NameNon-small cell lung cancer (A:m6A)
DescriptionmiR-143-3p is upregulated in the paired BM tissues as compared with that in primary cancer tissues. m6A methyltransferase Mettl3 can increase the splicing of precursor miR-143-3p to facilitate its biogenesis. It targets the three binding sites of 3’UTR of vasohibin-1 (VASH1) to inhibit its expression. Mechanistically, VASH1 can increase the ubiquitylation of VEGFA to trigger the proteasome mediated degradation, further, it can endow the tubulin depolymerization through detyrosination to increase the cell motility. Thus, miR-143-3p by inhibiting VASH1 t can increase the invasion capability and angiogenesis of lung cancer
Related RNA reactionA:m6A
Found in RNAmiRNA
Modified TranscriptmiR-143-3p
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to Non-small cell lung cancer:

Acronym Full name Enzyme Role Organism Comment
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1090 N6-methyladenosine induced miR-143-3p promotes the brain metastasis of lung cancer via regulation of VASH1. Hongsheng Wang Mol Cancer [details] 31823788 10.1186/s12943-019-1108-x