Modomics - A Database of RNA Modifications


NameNon-small cell lung cancer (A:m6A)
DescriptionMETTL3 is overexpressed in lung cancer tissues and cell lines. The m6A mRNA methylation initiated by METTL3 promotes YAP mRNA translation via recruiting YTHDF1/3 and eIF3b to the translation initiation complex and increases YAP mRNA stability through regulating the MALAT1-miR-1914-3p- YAP axis. The increased YAP expression and activity induce NSCLC drug resistance and metastasis.
Related RNA reactionA:m6A
Found in RNAmRNA, lncRNA
Modified TranscriptYAP, MALAT1
Mapping Technology
Quantification techniquesHPLC–tandem mass spectrometry, MeRIP-PCR

Enzymes connected to Non-small cell lung cancer:

Acronym Full name Enzyme Role Organism Comment
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1089 mA mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. Dan Jin J Hematol Oncol [details] 31818312 10.1186/s13045-019-0830-6