Modomics - A Database of RNA Modifications


NameLeukemia (A:m6A)
DescriptionMETTL14 is highly expressed in normal hematopoietic stem/progenitor cells (HSPCs) and acute myeloid leukemia (AML) cells carrying t(11q23), t(15;17), or t(8;21), and is down-regulated during myeloid differentiation. Mechanistically, METTL14 exerts its oncogenic role by regulating its mRNA targets (e.g., MYB and MYC) through m6A modification, which in turn leads to enhanced self-renewal/proliferation of LSCs/LICs and blockage of myeloid differentiation
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptMYB, MYC
Mapping TechnologyMeRIP-seq
Quantification techniquesLC-MS/MS

Enzymes connected to Leukemia:

Acronym Full name Enzyme Role Organism Comment
METTL14 N6-adenosine-methyltransferase non-catalytic subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1068 METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and PromotesLeukemogenesis via mRNA m(6)A Modification. Weng H Cell Stem Cell [details] 29290617 S1934-5909(17)30468-X