Modomics - A Database of RNA Modifications


NameLeukemia (A:m6A)
DescriptionFTO highly expressed in AML t(11q23)/MLL rearrangements, t(15;17)/PML-RARA, FLT3-ITD and/or NPM1 mutations. FTO enhances leukemic oncogene-mediated cell transformation and leukemogenesis, and inhibits all-trans-retinoic acid (ATRA)-induced AML cell differentiation, through regulating expression of targets such as ASB2 and RARA by reducing m6A levels in these mRNA transcripts.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified TranscriptASB2 and RARA
Mapping TechnologyMeRIP-seq
Quantification techniquesm6A quantification, Gene-Specific m6A qPCR

Enzymes connected to Leukemia:

Acronym Full name Enzyme Role Organism Comment
FTO Alpha-ketoglutarate-dependent dioxygenase FTO oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1064 FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N(6)-Methyladenosine RNADemethylase. Li Z Cancer Cell [details] 28017614 10.1016/j.ccell.2016.11.017