Modomics - A Database of RNA Modifications


NameLeukemia (A:m6A)
DescriptionMETTL3 is overexpressed in AML; Depletion of METTL3 induces cell differentiation and apoptosis and delays leukemia progression; m6A promotes translation of c-MYC, BCL2, PTEN mRNAs in AML. m6A depletion may activate the PI3K/AKT pathway.
Related RNA reactionA:m6A
Found in RNAmRNA
Modified Transcriptc-MYC, BCL2 and PTEN (acute myeloid leukemia)
Mapping TechnologymiCLIP
Quantification techniques"TLC (thin layer chromatography); MeRIP-qPCR"

Enzymes connected to Leukemia:

Acronym Full name Enzyme Role Organism Comment
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1063 The N-methyladenosine (mA)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Ly P Vu Nat Med [details] 28920958 10.1038/nm.4416