Modomics - A Database of RNA Modifications


NameHepatocellular carcinoma (A:I)
DescriptionAn increase in RNA editing on AZIN1 neutralizes a key inhibitor of the polyamine synthesis pathway, thereby promoting proliferation in vitro and tumor initiation in vivo. AZIN1 editing is associated with liver cirrhosis
Related RNA reactionA:I
Found in RNAmRNA
Modified TranscriptAZIN1
Mapping TechnologyRNA-seq
Quantification techniquesqRT-PCR

Enzymes connected to Hepatocellular carcinoma:

Acronym Full name Enzyme Role Organism Comment
ADAR Double-stranded RNA-specific adenosine deaminase oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1051 Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Leilei Chen Nat Med [details] 23291631 10.1038/nm.3043