Modomics - A Database of RNA Modifications


NameHepatocellular carcinoma (A:m6A)
DescriptionLINC00958 is upregulated in HCC cell lines and tissues. LINC00958 sponges miR-3619-5p which has among its targets HDGF which is important for lipogenesis. LINC00958 is upregulated in HCC cell lines and tissues, thus it icreases the interactions with miR-3619-5p, thus increasing HDGF mRNA expression levels. HDGF has been established as an oncogene that facilitates the progression of HCC. Furthermore, m6A methylation levels are enriched within LINC00958 in HCC cells and they correlate with and increased METTL3 expression level. These results suggest that the increase of LINC00958 in HCC may be attributed to the m6A modification.
Related RNA reactionA:m6A
Found in RNAlncRNA
Modified TranscriptLINC00958
Mapping Technology
Quantification techniquesMeRIP-qPCR

Enzymes connected to Hepatocellular carcinoma:

Acronym Full name Enzyme Role Organism Comment
METTL3 N6-adenosine-methyltransferase 70 kDa subunit oncogene Homo sapiens


ID Title Authors Journal Details PubMed Id DOI
1048 M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinoma. Xueliang Zuo J Hematol Oncol [details] 31915027 10.1186/s13045-019-0839-x